Protective effect of ginseng sapogenins against 2,2′-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK 1 cell damage

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 634-637

  Kang, Ki Sung ^a   Kim, Hyun Young ^b   Yoo, Hye Hyun ^c   Piao, Xiang Lan ^d   Ham, Jungyeob ^a   Yang, Hyun Ok ^a   Park, Jeong Hill ^e  

^a Korea Institute of Science and Technology   (South Korea)

^b Gyeongsang National University   (South Korea)

^c Hanyang University   (South Korea)

^d MINZU UNIVERSITY OF CHINA   (China)

^e Seoul National University   (South Korea)

Author keywords

Ginsenoside; Panax ginseng; Renoprotective activity; Sapogenin

Indexed keywords

2,2' AZOBIS( 1 AMINOPROPANE); ALKANE DERIVATIVE; GINSENG EXTRACT; GINSENOSIDE; HYDROXYL GROUP; PLANT MEDICINAL PRODUCT; PROTOPANAXATRIOL; SAPOGENIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL STRAIN; CHEMICAL BOND; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; GINSENG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY EPITHELIUM; NONHUMAN; OXIDATIVE STRESS; RENAL PROTECTION; STRUCTURE ACTIVITY RELATION;

AMIDINES; ANIMALS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DESIGN; EPITHELIAL CELLS; KIDNEY; LLC-PK1 CELLS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PANAX; SAPOGENINS; SWINE; TIME FACTORS;

PANAX GINSENG;

EID: 84655161551     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.10.063     Document Type: Article

References (24)

1. Y.S. Keum, K.K. Park, J.M. Lee, K.S. Chun, J.H. Park, S.K. Lee, H. Kwon, and Y.J. Surh Cancer Lett. 13 2000 41
2. W.Y. Kim, J.M. Kim, S.B. Han, S.K. Lee, N.D. Kim, M.K. Park, C.K. Kim, and J.H. Park J. Nat. Prod. 63 2000 1702
3. K.S. Kang, H.Y. Kim, J.S. Pyo, and T. Yokozawa Biol. Pharm. Bull. 29 2006 750
4. K.S. Kang, T. Yokozawa, N. Yamabe, H.Y. Kim, and J.H. Park Biol. Pharm. Bull. 30 2007 917
5. N. Yamabe, J.G. Lee, Y.J. Lee, C.H. Park, H.Y. Kim, J.H. Park, T. Yokozawa, and K.S. Kang J. Ginseng Res. 35 2011 60
6. R. Nistala, A. Whaley-Connell, and J.R. Sowers Antioxid. Redox Signal. 10 2008 2047
7. S.H. Baek, X.L. Piao, U.J. Lee, H.Y. Kim, and J.H. Park Biol. Pharm. Bull. 29 2006 2051
8. S. Shibata, O. Tanaka, M. Nagai, and T. Ishii Chem. Pharm. Bull. 11 1963 762
9. J. Asakawa, R. Kasai, K. Yamasaki, and O. Tanaka Tetrahedron 33 1977 1935
10. H. Hasegawa, and M. Uchiyama Planta Med. 64 1998 696
11. S.W. Kwon, S.B. Han, I.H. Park, J.M. Kim, M.K. Park, and J.H. Park J. Chromatogr. A 921 2001 335
12. I.H. Park, N.Y. Kim, S.B. Han, J.M. Kim, S.W. Kwon, H.J. Kim, M.K. Park, and J.H. Park Arch. Pharm. Res. 25 2002 428
13. T. Yokozawa, E.J. Cho, Y. Hara, and K. Kitani J. Agric. Food Chem. 48 2000 5068
14. J.F. Cui, S. Bystrom, P. Eneroth, and H. Bjorkhem J. Org. Chem. 59 1994 8251
15. K.S. Im, E.H. Chang, and N.G. Je Arch. Pharm. Res. 18 1995 454
16. M. Miki, H. Tamai, M. Mino, Y. Yamamoto, and E. Niki Arch. Biochem. Biophy. 258 1987 373
17. H.H. Kwok, W.Y. Ng, M.S. Yang, N.K. Mak, R.N. Wong, and P.Y. Yue Free Radic. Biol. Med. 48 2010 437
18. C.A. Rice-Evans, N.J. Miller, and G. Paganga Free Radic. Biol. Med. 20 1996 933
19. E.J. Lien, S. Ren, H.H. Bui, and R. Wang Free Radic. Biol. Med. 26 1999 285
20. J.M. Tanko Annu. Rep. Prog. Chem. 99 2003 326
21. H. Fujita, H. Fujishima, S. Chida, K. Takahashi, Z. Qi, Y. Kanetsuna, M.D. Breyer, R.C. Harris, Y. Yamada, and T.J. Takahashi J. Am. Soc. Nephrol. 20 2009 1303
22. H. Ha, I.A. Hwang, J.H. Park, and H.B. Lee Diabetes Res. Clin. Pract. 82 2008 S42
23. K.S. Kang, N. Yamabe, H.Y. Kim, J.H. Park, and T. Yokozawa Eur. J. Pharmacol. 591 2008 266
24. K.S. Kang, N. Yamabe, H.Y. Kim, J.H. Park, and T. Yokozawa Biol. Pharm. Bull. 33 2010 1077