Effects of Red Ginseng Extract on the Epididymal Sperm Motility of Mice Exposed to Ethanol

International Journal of Toxicology

Volumn 30, Issue 4, 2011, Pages 435-442

  Jang, Mi ^a   Min, Jin Woo ^a   In, Jun Gyo ^a   Yang, Deok Chun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

ethanol; ginseng wine; hormone; red ginseng extract; sperm motility

Indexed keywords

ALCOHOL; FOLLITROPIN; GINSENOSIDE; LUTEINIZING HORMONE; PLANT EXTRACT; TESTOSTERONE; GINSENG EXTRACT; SODIUM CHLORIDE;

ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; CHEMISTRY; DRUG EFFECT; EPIDIDYMIS; FERTILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMAGE PROCESSING; MALE; METABOLISM; MOUSE; PANAX; PHYTOTHERAPY; SPERMATOZOON MOTILITY; TESTIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; COMPUTER ANALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; FOLLITROPIN BLOOD LEVEL; GINSENG; LUTEINIZING HORMONE BLOOD LEVEL; MALE FERTILITY; MALE REPRODUCTIVE SYSTEM PROTECTION; NONHUMAN; ORGAN WEIGHT; PROTECTION; REPRODUCTIVE TOXICITY; SEMEN ANALYSIS; SEMINAL VESICLE; SPERM QUALITY; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPIDIDYMIS; ETHANOL; FERTILITY; FOLLICLE STIMULATING HORMONE; GINSENOSIDES; IMAGE PROCESSING, COMPUTER-ASSISTED; LUTEINIZING HORMONE; MALE; MICE; MICE, INBRED C57BL; PANAX; PHYTOTHERAPY; PLANT EXTRACTS; SPERM MOTILITY; TESTIS; TESTOSTERONE;

EID: 84555196740     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1177/1091581811405074     Document Type: Article

References (45)

1. Cicero TJ, Bell RD. Ethanol-induced reductions in testicular steroidogenesis: major differences between in vivo and in vitro approaches. Steroids. 1982; 40(5):561–568.
2. Cicero TJ, Badger TM. Effects of alcohol on the hypothalamic-pituitary-gonadal axis in the male rat. J Pharmacol Exp Ther. 1977; 201(2):427–433.
3. Les Dees W, Rettori V, Kozlowski GP, McCann SM. Ethanol and the pulsatile release of luteinizing hormone, follicle stimulating hormone and prolactin in ovariectomized rats. Alcohol. 1985; 2(5):641–646.
4. Canteros MG, Franch AM, Suburo A, Genaro A, Cebral E, Rettori V. Ethanol mechanism(s) of action on LHRH secretion. Acta Physiol Pharmacol Ther Latinoam. 1995; 45(1):55–63.
5. Emanuele MA, Tentler J, Emanuele NV, Kelley MR. In vivo effects of acute EtOH on rat α and β luteinizing hormone gene expression. Alcohol. 1991; 8(5):345–348.
6. Orpana AK, Orava MM, Vihko RK, Härkönen M, Eriksson CJ. Role of ethanol metabolism in the inhibition of testosterone biosynthesis in rats in vivo: importance of gonadotropin stimulation. J Steroid Biochem. 1990; 37(2):273–278.
7. Uddin S, Emanuele MA, Emanuele NV, Reda D, Kelley MR. The effect of in vitro ethanol exposure on luteinizing hormone and follicle stimulating hormone mRNA levels, content, and secretion. Endocr Res. 1994; 20(2):201–217.
8. Adler RA. Clinical review 33: clinically important effects of alcohol on endocrine function. J Clin Endocrinol Metab. 1992; 74(5):957–960.
9. Villalta J, Ballesca JL, Nicolas JM, Martínez de Osaba MJ, Antúnez E, Pimentel C. Testicular function in asymptomatic chronic alcoholics: relation to ethanol intake. Alcohol Clin Exp Res. 1997; 21(1):128–133.
10. Ren JC, Banan A, Keshavarzian A, et al. Exposure to ethanol induces oxidative damage in the pituitary gland. Alcohol. 2005; 35(2):91–101.
11. Van Thiel DH, Lester R, Sherins RJ. Hypogonadism in alcoholic liver disease: evidence for a double defect. Gastroenterology. 1974; 67(6):1188–1199.
12. Van Thiel DH, Gavaler JS, Eagon PK, Chiao YB, Cobb CF, Lester R. Alcohol and sexual function. Phamacol Biochem Behav. 1980; 13(1):125–129.
13. Kim JH, Kim HJ, Noh HS, et al. Suppression by ethanol of male reproductive activity. Brain Res. 2003; 989(1):91–98.
14. Kim MW, Ko SR. Distribution of saponin in various sections of Panax ginseng root and change of its contents according to root age. Kor J Ginseng Sci. 1987; 11(1):10–16.
15. Ali MB, Hahn EJ, Paek KY. CO2-induced total phenolics in suspension cultures of Panax ginseng C. A. Mayer roots: role of antioxidants and enzymes. Plant Physiol Biochem. 2005; 43(5):449–457.
16. Hwang Wl. A study on the antitumor activity of Panax ginseng. J Ginseng Sci. 1993; 17(1):52–60.
17. Jeon BH, Kim CS, Park KS, et al. Effect of Korea red ginseng on blood pressure in conscious hypertensive rats. Gen Pharmacol. 2000; 35(3):135–141.
18. Yuan HD, Shin EJ, Chung SH. Anti-diabetic effect and mechanism of Korean red ginseng in C57BL/KsJ db/db Mice. J Ginseng Sci. 2008; 32(3):187–193.
19. Kim ND, Hahn BH, Lee EB, et al. Studies of ginseng on the antistress effects. Korean J Pharmacog. 1979; 10(2):61–67.
20. Hong B, Ji YH, Hong JH, Nam KY, Ahn TY. A double-blind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol. 2002; 168(5):2070–2073.
21. Kang JK, Lee YJ, No KO, et al. Ginseng intestinal metabolite-I (GIM-I) reduces doxorubicin toxicity in the mouse testis. Reprod Toxicol. 2002; 16(3):291–298.
22. Park JS, Hwang SY, Lee WS, et al. The therapeutic effect of tissue cultured root of wild Panax ginseng C.A. Mayer on spermatogenetic disorder. Arch Pharm Res. 2006; 29(9):800–807.
23. Chen JC, Xu MX, Chen LD, Chen YN, Chiu TH. Effect of Panax notoginseng extracts on inferior sperm motility in vitro. Am J Chin Med. 1999; 27(1):123–128.
24. Chen JC, Chen LD, Tsauer W, Tsai CC, Chen BC, Chen YJ. Effects of ginsenoside Rb2 and Rc on inferior human sperm motility in vitro. Am J Chin Med. 2001; 29(1):155–160.
25. Connolly CM, Dearth AT, Braun RE. Disruption of murine Tenr results in teratospermia and male infertility. Dev Biol. 2005; 1278(1):13–21.
26. Matsuura H, Kasai R, Tanaka O, et al. Further studies on the dammarane-saponins of ginseng roots. Chem Pharm Bull (Tokyo). 1984; 32: 1188–1192.
27. De Smet PAGM. Herbal remedies. N Engl Med. 2002; 347(25):2046–2056.
28. Shibata S, Fujita M, Itokawa H, Tanaka O, Ishii T. Studies on the constituents of Japanese and Chinese Crude Drugs. XI. Panaxadiol, a sapogenin of ginseng roots. Chem Pharm Bull (Tokyo). 1963; 11: 759–761.
29. Crissman JW, Goodman DG, Hildebrandt PK, et al. Best practices guideline: toxicologic histopathology. Toxicol Pathol. 2004; 32(1):126–131.
30. Dare WN, Noronha CC, Kusemiju OT, Okanlawon OA. The effect of ethanol on spermatogenesis and fertility in male Sprague-Dawley rats pretreated with acetylsalicylic acid. Niger Postgrad Med J. 2002; 9(4):194–198.
31. Srikhanth V, Malini T, Arunakaran J, Govindarajulu P, Balasubramanian K. Effects of ethanol treatment on epididymal secretory products and sperm maturation in albino rats. J Pharmacol Exp Ther. 1999; 288(2):509–515.
32. Hood RD. Developmental and Reproductive Toxicology, A Practical Approach. 2nd ed. USA: CRC Press; 2005; 444–446.
33. Jelski W, Chrostek L, Szmitkowski M. Biochemical basic of alcoholic liver injury. Pol Merkur Lekarski. 2006; 21(124):376–380.
34. Salvati G, Genovesi G, Marcellini L, et al. Effects of Panax Ginseng C.A. Meyer saponins on male fertility. Panminerva Med. 1996; 38(4):249–254.
35. Von der Pahen B. The role of alcohol and steroid hormone in human aggression. Vitam Horm. 2005; 70: 415–473.
36. Anderson RA Jr, Willis BR, Oswald C, Zaneveld LJ. Male reproductive tract sensitivity to ethanol: a critical overview. Pharmacol Biochem Behav. 1983; 18(1):305–310.
37. Gomathi C, Balasubramanian K, Vijayabanu N, Srikanth V, Govindarajulu P. Effects of chronic alcoholism on semen studies on lipid profiles. Int J Androl. 1993; 16(3):175–181.
38. Choi GY, Cho JH, Jang JB, et al. Effects of Panax ginseng on the sperm motility and spermatogenesis in the SD rat. J Kor Oriental Med. 2004; 25(4):90–94.
39. Dahlberg B. Sperm motility in fertile men and males in infertile units: in vitro test. Arch Androl. 1988; 20(1):31–34.
40. Fahim MS, Fahim Z, Harman JM, Clevenger TE, Mullins W, Hafez ES. Effect of Panax ginseng on testosterone level and prostate in male rats. Arch Androl. 1982; 8(4):261–263.
41. Choi HK, Choi YD, Adaikan PG, et al. Effectiveness of Korea red ginseng in erectile dysfunction-multi-national approach. J Ginseng Res. 1999; 23(4):247–256.
42. Akagawa G, Abe S, Tansho S, et al. Protection of C3H/HE J mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, Ginseng radix: possible roles of macrophages in the host defense mechanisms. Immunopharmacol Immunotoxicol. 1996; 18(1):73–89.
43. Boockfor FR, Blake CA. Chronic administration of 4-tert-octylphenol to adult male rats causes shrinkage of the testes and male accessory sex organs, disrupts spermatogenesis, and increases the incidence of sperm deformities. Biol Reprod. 1997; 57(2):267–277.
44. Widenius TV, Peter Eriksson CJ, Ylikahri RH, Härkönen M. Inhibition of testosterone synthesis by ethanol: role of luteinizing hormone. Alcohol. 1989; 6(3):241–244.
45. Dees WL, Skelley CW, Hiney JK, Johnston CA. Actions of ethanol on hypothalamic and pituitary hormones in prepubertal female rats. Alcohol. 1990; 7(1):21–25.