Direct comparison of the traditional and reverse syphilis screening algorithms in a population with a low prevalence of syphilis

Journal of Clinical Microbiology

Volumn 50, Issue 1, 2012, Pages 148-150

  Binnicker, Matthew J ^a   Jespersen, Deborah J ^a   Rollins, Leonard O ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLUTINATION TEST; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FALSE POSITIVE RESULT; HUMAN; IMMUNOASSAY; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MULTIPLEX FLOW IMMUNOASSAY; NEUROSYPHILIS; PREVALENCE; PRIORITY JOURNAL; REAGIN TEST; SCREENING TEST; SENSITIVITY AND SPECIFICITY; SYPHILIS; TREPONEMA PALLIDUM; TREPONEMA PALLIDUM PARTICLE AGGLUTINATION ASSAY;

ALGORITHMS; CLINICAL LABORATORY TECHNIQUES; DIAGNOSTIC ERRORS; HUMANS; MASS SCREENING; PREVALENCE; SENSITIVITY AND SPECIFICITY; SYPHILIS;

EID: 84555188038     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.05636-11     Document Type: Article

References (6)

1. Association of Public Health Laboratories. 2009. Laboratory diagnostic testing for Treponema pallidum - expert consultation meeting summary report, January 13-15, 2009. Atlanta, GA. Association of Public Health Laboratories, Silver Spring, MD. http://www.aphl.org/aphlprograms/infectious/std/Documents/ LaboratoryGuidelinesTreponemapallidumMeetingReport.pdf.
2. Centers for Disease Control and Prevention. 2011. Discordant results from reverse sequence syphilis screening - five laboratories, United States, 2006-2010. MMWR Morb. Mortal. Wkly. Rep. 60:133-137.
3. Centers for Disease Control and Prevention. 2008. Syphilis testing algorithms using treponemal tests for initial screening - four laboratories, New York City, 2005-2006. MMWR Morb. Mortal. Wkly. Rep. 57:872-875.
4. Gomez E, Jespersen DJ, Harring JA, Binnicker MJ. 2010. Evaluation of the Bio-Rad BioPlex 2200 syphilis multiplex flow immunoassay for the detection of IgM- and IgG-class antitreponemal antibodies. Clin. Vaccine Immunol. 17:966-968.
5. Mishra S, et al. 2011. The laboratory impact of changing syphilis screening from the rapid-plasma reagin to a treponemal enzyme immunoassay: a case-study from the Greater Toronto Area. Sex. Transm. Dis. 38:190-196.
6. Sena AC, White BL, Sparling PF. 2010. Novel Treponema pallidum serologic tests: a paradigm shift in syphilis screening for the 21st century. Clin. Infect. Dis. 51:700-708.