Ethanol increases GABAergic transmission and excitability in cerebellar molecular layer interneurons from GAD67-GFP knock-in mice

Alcohol and Alcoholism

Volumn 47, Issue 1, 2012, Pages 1-8

  Wadleigh, Aya ^a   Valenzuela, C Fernando ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; GLUTAMATE DECARBOXYLASE 67; GREEN FLUORESCENT PROTEIN; MOLECULAR LAYER;

ACTION POTENTIAL; ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL ADHESION; CEREBELLUM CORTEX; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GABAERGIC TRANSMISSION; INHIBITORY POSTSYNAPTIC POTENTIAL; INTERNEURON; MALE; MOUSE; NERVE CELL EXCITABILITY; NONHUMAN; PACEMAKER; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PURKINJE CELL; STELLATE CELL; SYNAPSE; WHOLE CELL;

ANIMALS; CEREBELLUM; ETHANOL; GABAERGIC NEURONS; GENE KNOCK-IN TECHNIQUES; GLUTAMATE DECARBOXYLASE; GREEN FLUORESCENT PROTEINS; INHIBITORY POSTSYNAPTIC POTENTIALS; INTERNEURONS; MALE; MICE; MICE, TRANSGENIC; SYNAPTIC TRANSMISSION;

MUS; MUS MUSCULUS;

EID: 84555178693     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agr147     Document Type: Article

References (36)

1. Bao J, Reim K, Sakaba T. (2010) Target-dependent feedforward inhibition mediated by short-term synaptic plasticity in the cerebellum. J Neurosci 30:8171-9.
2. Barlow JS. (2002) The cerebellum and adaptive control. In Anatomy and Physiology of the Cerebellar Cortex. Cambridge: Cambridge University Press, 17-26.
3. Botta P, Radcliffe RA, Carta M et al. (2007) Modulation of GABA (A) receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies. Alcohol 41:187-99.
4. Botta P, de Souza FM, Sangrey T et al. (2010) Alcohol excites cerebellar Golgi cells by inhibiting the Na+/K+ ATPase. Neuropsychopharmacology 35:1984-96.
5. Briatore F, Patrizi A, Viltono L et al. (2010) Quantitative organization of GABAergic synapses in the molecular layer of the mouse cerebellar cortex. PLoS One 5:e12119.
6. De Zeeuw CI, Hoebeek FE, Schonewille M. (2008) Causes and consequences of oscillations in the cerebellar cortex. Neuron 58:655-8.
7. Fitzpatrick LE, Jackson M, Crowe SF. (2008) The relationship between alcoholic cerebellar degeneration and cognitive and emotional functioning. Neurosci Biobehav Rev 32:466-85.
8. Hausser M, Clark BA. (1997) Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron 19:665-78.
9. Hirono M, Obata K. (2006) Alpha-adrenoceptive dual modulation of inhibitory GABAergic inputs to Purkinje cells in the mouse cerebellum. J Neurophysiol 95:700-8.
10. Hirono M, Yamada M, Obata K. (2009) Ethanol enhances both action potential-dependent and action potential-independent GABAergic transmission onto cerebellar Purkinje cells. Neuropharmacology 57:109-20.
11. Ito M. (2006) Cerebellar circuitry as a neuronal machine. Prog Neurobiol 78:272-303.
12. Jaatinen P, Rintala J. (2008) Mechanisms of ethanol-induced degeneration in the developing, mature, and aging cerebellum. Cerebellum 7:332-47.
13. Jorntell H, Ekerot CF. (2003) Receptive field plasticity profoundly alters the cutaneous parallel fiber synaptic input to cerebellar interneurons in vivo. J Neurosci 23:9620-31.
14. Jorntell H, Bengtsson F, Schonewille M et al. (2010) Cerebellar molecular layer interneurons - computational properties and roles in learning. Trends Neurosci 33:524-32.
15. Kelm MK, Criswell HE, Breese GR. (2007) Calcium release from presynaptic internal stores is required for ethanol to increase spontaneous gamma-aminobutyric acid release onto cerebellum Purkinje neurons. J Pharmacol Exp Ther 323:356-64.
16. Kelm MK, Criswell HE, Breese GR. (2011) Ethanol-enhanced GABA release: a focus on G protein-coupled receptors. Brain Res Rev 65:113-23.
17. Kondo S, Marty A. (1998) Synaptic currents at individual connections among stellate cells in rat cerebellar slices. J Physiol 509 (Pt 1):221-32.
18. Llano I, Gerschenfeld HM. (1993) Inhibitory synaptic currents in stellate cells of rat cerebellar slices. J Physiol 468:177-200.
19. Maex R, De Schutter E. (2005) Oscillations in the cerebellar cortex: a prediction of their frequency bands. Prog Brain Res 148:181-8.
20. Mameli M, Botta P, Zamudio PA et al. (2008) Ethanol decreases Purkinje neuron excitability by increasing GABA release in rat cerebellar slices. J Pharmacol Exp Ther 327:910-7.
21. Mann-Metzer P, Yarom Y. (2002) Pre- and postsynaptic inhibition mediated by GABA(B) receptors in cerebellar inhibitory interneurons. J Neurophysiol 87:183-90.
22. Middleton SJ, Racca C, Cunningham MO et al. (2008) High-frequency network oscillations in cerebellar cortex. Neuron 58:763-74.
23. Ming Z, Criswell HE, Yu G et al. (2006) Competing presynaptic and postsynaptic effects of ethanol on cerebellar purkinje neurons. Alcohol Clin Exp Res 30:1400-7.
24. O'Donoghue DL, King JS, Bishop GA. (1989) Physiological and anatomical studies of the interactions between Purkinje cells and basket cells in the cat's cerebellar cortex: evidence for a unitary relationship. J Neurosci 9:2141-50.
25. Rancillac A, Crepel F. (2004) Synapses between parallel fibres and stellate cells express long-term changes in synaptic efficacy in rat cerebellum. J Physiol 554:707-20.
26. Rangaraj N, Kalant H. (1980) Alpha adrenoreceptor mediated alteration of ethanol effects on (Na++K+)-ATPase of rat neuronal membranes. Can J Physiol Pharmacol 58:1342-6.
27. Rangaraj N, Kalant H, Beauge F. (1985) Alpha 1-adrenergic receptor involvement in norepinephrine-ethanol inhibition of rat brain Na+-K+ ATPase and in ethanol tolerance. Can J Physiol Pharmacol 63:1075-9.
28. Rice ME. (1999) Use of ascorbate in the preparation and maintenance of brain slices. Methods 18:144-9.
29. Scelfo B, Sacchetti B, Strata P. (2008) Learning-related long-term potentiation of inhibitory synapses in the cerebellar cortex. Proc Natl Acad Sci USA 105:769-74.
30. Soler-Llavina GJ, Sabatini BL. (2006) Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells. Nat Neurosci 9:798-806.
31. Sotelo C, Llinas R. (1972) Specialized membrane junctions between neurons in the vertebrate cerebellar cortex. J Cell Biol 53:271-89.
32. Southan AP, Robertson B. (1998) Modulation of inhibitory postsynaptic currents (IPSCs) in mouse cerebellar Purkinje and basket cells by snake and scorpion toxin K+ channel blockers. Br J Pharmacol 125:1375-81.
33. Tamamaki N, Yanagawa Y, Tomioka R et al. (2003) Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol 467:60-79.
34. Valenzuela CF, Lindquist B, Zamudio-Bulcock PA. (2010) A review of synaptic plasticity at Purkinje neurons with a focus on ethanol-induced cerebellar dysfunction. Int Rev Neurobiol 91:339-72.
35. Vincent P, Marty A. (1993) Neighboring cerebellar Purkinje cells communicate via retrograde inhibition of common presynaptic interneurons. Neuron 11:885-93.
36. Wulff P, Schonewille M, Renzi M et al. (2009) Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning. Nat Neurosci 12:1042-9.