A bi-functional hepatitis B virus core antigen (HBcAg) chimera activates HBcAg-specific T cells and preS1-specific antibodies

Scandinavian Journal of Infectious Diseases

Volumn 44, Issue 1, 2012, Pages 55-59

  Malik, Imran Riaz ^a,b   Chen, Antony ^a   Brass, Anette ^a   Ahlén, Gustaf ^a   Rahman, Moazur ^b   Sällberg, Matti ^a   Qureshi, Javed Anver ^b   Frelin, Lars ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NATIONAL INSTITUTE FOR BIOTECHNOLOGY AND GENETIC ENGINEERING NIBGE   (Pakistan)

Author keywords

HBcAg; HBV; PreS1; T cell; Vaccine

Indexed keywords

HEPATITIS B CORE ANTIGEN; HEPATITIS B SURFACE ANTIGEN; PRES1 PROTEIN; PROTEIN PC42; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHIMERA; FEMALE; HEPATITIS B; IMMUNOGENICITY; LOW DRUG DOSE; MOUSE; NONHUMAN; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, NEUTRALIZING; FEMALE; HEPATITIS B CORE ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; IMMUNITY, CELLULAR; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES; VACCINATION; VACCINES, SYNTHETIC;

EID: 84555177509     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365548.2011.608711     Document Type: Article

References (16)

1. Yang JD, Roberts LR. Hepatocellular carcinoma: a global view. Nat Rev Gastroenterol Hepatol 2010;7:448-58.
2. Beck J, Nassal M. Hepatitis B virus replication. World J Gastroenterol 2007;13:48-64. (Pubitemid 46165462)
3. Milich DR, McLachlan A. The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen. Science 1986;234:1398-401. (Pubitemid 17210220)
4. Rehermann B, Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 2005;5:215-29. (Pubitemid 40364823)
5. Billaud JN, Peterson D, Barr M, Chen A, Sallberg M, Garduno et al. Combinatorial approach to hepadnavirus-like particle vaccine design. J Virol 2005;79:13656-66. (Pubitemid 41508177)
6. Lazdina U, Alheim M, Nystrom J, Hultgren C, Borisova G, Sominskaya I, et al. Priming of cytotoxic T cell responses to exogenous hepatitis B virus core antigen is B cell dependent. J Gen Virol 2003;84(Pt 1):139-46. (Pubitemid 36113559)
7. Lazdina U, Cao T, Steinbergs J, Alheim M, Pumpens P, Peterson DL, et al. Molecular basis for the interaction of the hepatitis B virus core antigen with the surface immunoglobulin receptor on naive B cells. J Virol 2001;75:6367-74. (Pubitemid 32578155)
8. Milich DR, Chen M, Schodel F, Peterson DL, Jones JE, Hughes JL. Role of B cells in antigen presentation of the hepatitis B core. Proc Natl Acad Sci USA 1997;94: 14648-53. (Pubitemid 28041428)
9. Soderholm J, Ahlen G, Kaul A, Frelin L, Alheim M, Barnfi eld C, et al. Relation between viral fi tness and immune escape within the hepatitis C virus protease. Gut 2006;55: 266-74. (Pubitemid 43117288)
10. Ahlen G, Derk E, Weiland M, Jiao J, Rahbin N, Aleman S, et al. Cleavage of the IPS-1/Cardif/MAVS/VISA does not inhibit T cell-mediated elimination of hepatitis C virus non-structural 3/4A-expressing hepatocytes. Gut 2009;58: 560-9.
11. Ahlen G, Nystrom J, Pult I, Frelin L, Hultgren C, Sallberg M. In vivo clearance of hepatitis C virus nonstructural 3/4aexpressing hepatocytes by DNA vaccine-primed cytotoxic T lymphocytes. J Infect Dis 2005;192:2112-6. (Pubitemid 41779209)
12. Nystrom J, Chen A, Frelin L, Ahlen G, Koh S, Brass A, et al. Improving on the ability of endogenous hepatitis B core antigen to prime cytotoxic T lymphocytes. J Infect Dis 2010;201:1867-79.
13. Milich DR, McLachlan A, Moriarty A, Thornton GB. A single 10-residue pre-S(1) peptide can prime T cell help for antibody production to multiple epitopes within the pre- S(1), pre-S(2), and S regions of HBsAg. J Immunol 1987;138:4457-65. (Pubitemid 17090426)
14. Woo G, Tomlinson G, Nishikawa Y, Kowgier M, Sherman M, Wong DK, et al. Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses. Gastroenterology 2010; 139:1218-29.
15. G uidotti LG, Chisari FV. Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol 2006;1:23-61.
16. Lee BO, Tucker A, Frelin L, Sallberg M, Jones J, Peters C, et al. Interaction of the hepatitis B core antigen and the innate immune system. J Immunol 2009;182:6670-81.