Dosing of oral penicillins in children: Is big child=half an adult, small child=half a big child, baby=half a small child still the best we can do?

BMJ (Online)

Volumn 343, Issue 7837, 2011, Pages

  Ahmed, Umar ^a,b   Spyridis, Nikos ^c,d   Wong, Ian C K ^a,e   Sharland, Mike ^c   Long, Paul F ^a,f  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b Boots The Chemist   (United Kingdom)

^c ST GEORGE S HOSPITAL   (United Kingdom)

^d UNIVERSITY OF ATHENS   (Greece)

^e UNIVERSITY OF HONG KONG   (Hong Kong)

^f KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIRETROVIRUS AGENT; FLUCLOXACILLIN; PENICILLIN G; PENICILLIN V; ANTIINFECTIVE AGENT;

AGE DISTRIBUTION; ANTIBIOTIC RESISTANCE; BODY WEIGHT; CHILD; DRUG DOSE REGIMEN; DRUG UNDERDOSE; HUMAN; MEDICATION ERROR; PEDIATRICS; PRESCRIPTION; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; RISK BENEFIT ANALYSIS; SINGLE DRUG DOSE; ADULT; AGE; ARTICLE; CLINICAL PRACTICE; DOSE RESPONSE; GRAM POSITIVE INFECTION; INFANT; ORAL DRUG ADMINISTRATION; PRESCHOOL CHILD; STATISTICS;

ADMINISTRATION, ORAL; ADULT; AGE FACTORS; ANTI-BACTERIAL AGENTS; BODY WEIGHT; CHILD; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG PRESCRIPTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INFANT; PEDIATRICS; PENICILLIN V; PHYSICIAN'S PRACTICE PATTERNS;

EID: 84455205975     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.d7803     Document Type: Review

References (22)

1. Thompson PL, Spyridis N, Sharland M, Gilbert RE, Saxena S, Long PF, et al. Changes in clinical indications for community antibiotic prescribing for children in the UK from 1996 to 2006: will the new NICE prescribing guidance on upper respiratory tract infections just be ignored? Arch Dis Child 2009;94:337-40.
2. Electronic Medicines Compendium. Summary of product characteristics: Amoxil paediatric suspension. 2011. www.medicines.org.uk/EMC/medicine/12637/SPC/ Amoxil+Paediatric+Suspension.
3. Buchnan JL. Penicillin in infancy and childhood. Lancet 1946;248:560-2.
4. Henderson JL, McAdam IWJ. Oral administration of penicillin to infants. Lancet 1946;247:922-5.
5. Hoffman WS, Hofer JW, Gordon H. The treatment of acute respiratory infections in children with orally administered, unbuffered penicillin solutions. J Pediatr 1948;32:1-9.
6. Moseley JH. The place of oral penicillin in paediatrics. Arch Dis Child 1948;23:93-7.
7. Suchett-Kaye AI, Latter RB. Oral penicillin in young children. BMJ 1947;ii:953-4.
8. Knudsen LF, Randall WA. Penicillin assay and its control chart analysis. J Bacteriol 1945;50:187-200.
9. Young BA. Medical aspects of penicillin treatment. BMJ 1947;viii:290-3.
10. Emery JL, Rose LM, Stewart SM, Wayne EJ. The use in children of procaine penicillin with aluminium monostearate. BMJ 1949;i:1110-2.
11. Wheatley D. Oral penicillin in general practice. BMJ 1958;2:907-9.
12. Hausmann E, Zischinsky H. Experience with ospen, a new oral penicillin therapy, in children. Wien Med Wochenschr 1953;103:725-7.
13. Spitzy, KH. Oral penicillin therapy. Wien Klin Wochenschr 1955;67:212-3.
14. Anon. Today's drug: paediatric prescribing (contd). BMJ 1963;ii:1577-8.
15. NMH Information Centre. Health survey for England 2009. Children trends table. www.ic. nhs.uk/statistics-and-data-collections/health-and-lifestyles- related-surveys/health-survey-for- england/health-survey-for-england--2009- trend-tables.
16. American Academy of Pediatrics Subcommittee on management of acute otitis media. Pediatrics 2004;113:1451-65.
17. Chung A, Perera R, Brueggemann AB, Elamin AE, Harnden A, Mayon-White R, et al. Effect of antibiotic prescribing on antibiotic resistance in individual children in primary care: prospective cohort study. BMJ 2007;335:429-34.
18. Vergison A, Dagan R, Arguedas A, Bonhoeffer J, Cohen R, Dhooge I, et al. Otitis media and its consequences: beyond the earache. Lancet Infect Dis 2010;10:195-203.
19. Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: a systematic review and meta-analysis. BMJ 2010;340:c2096.
20. Keith T, Saxena S, Murray J, Sharland M. Risk-benefit analysis of restricting antimicrobial prescribing in children: what do we really know? Curr Opin Infect Dis 2010;23:242-8.
21. Menson EN, Walker AS, Sharland M, Wells C, Tudor-Williams G, Riordan FAI, et al. Underdosing of antiretrovirals in UK and Irish children with HIV as an example of problems in prescribing medicines to children, 1997-2005: cohort study. BMJ 2006;332:1183-7.
22. PENTA 2009 guidelines for the use of antiretroviral therapy in paediatric HIV-1 infection. HIV Med 2009;10:591-613.