The supplementation of zinc increased the apoptosis of airway smooth muscle cells by increasing p38 phosphorylation

Environmental Toxicology and Pharmacology

Volumn 33, Issue 1, 2012, Pages 70-77

  Chiou, Ya Ling ^a  

^a HUNGKUANG UNIVERSITY   (Taiwan)

Author keywords

Airway smooth muscle cells; Apoptosis; Asthma; PDGF; Proliferation; Zinc

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; ZINC SULFATE;

AIRWAY SMOOTH MUSCLE CELL; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; CELLS, CULTURED; DIETARY SUPPLEMENTS; HUMANS; MALE; MYOCYTES, SMOOTH MUSCLE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RESPIRATORY SYSTEM; SIGNAL TRANSDUCTION; ZINC;

EID: 84455200423     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2011.11.002     Document Type: Article

References (30)

1. Bao S., Knoell D.L. Zinc modulates airway epithelium susceptibility to death receptor-mediated apoptosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 2006, 290:L433-L441.
2. Barnes P.J., Pedersen S., Busse W.W. Efficacy and safety of inhaled corticosteroids. New developments. Am. J. Respir. Crit. Care Med. 1998, 157:S1-S53.
3. Bousquet J., Jeffery P.K., Busse W.W., Johnson M., Vignola A.M. Asthma from bronchoconstriction to airways inflammation and remodelling. Am. J. Respir. Crit. Care Med. 2000, 161:1720-1745.
4. Carter J.E., Truong-Tran A.Q., Grosser D., Ho L., Ruffin R.E., Zalewski P.D. Involvement of redox events in caspase activation in zinc-depleted airway epithelial cells. Biochem. Biophys. Res. Commun. 2002, 297:1062-1070.
5. de Luis D.A., Izaola O., Aller R., Armentia A., Cuellar L. Antioxidant and fat intake in patients with polinic asthma. Med. Clin. (Barc.) 2003, 121:653-654.
6. Devereux G., Turner S.W., Craig L.C., McNeill G., Martindale S., Harbour P.J., Helms P.J., Seaton A. Low maternal vitamin E intake during pregnancy is associated with asthma in 5-year-old children. Am. J. Respir. Crit. Care Med. 2006, 174:499-507.
7. Gallelli L., Pelaia G., Fratto D., Muto V., Falcone D., Vatrella A., Curto L.S., Renda T., Busceti M.T., Liberto M.C., et al. Effects of budesonide on P38 MAPK activation, apoptosis and IL-8 secretion, induced by TNF-alpha and haemophilus influenzae in human bronchial epithelial cells. Int. J. Immunopathol. Pharmacol. 2010, 23:471-479.
8. Hennig B., Meerarani P., Ramadass P., Toborek M., Malecki A., Slim R., McClain C.J. Zinc nutrition and apoptosis of vascular endothelial cells: implications in atherosclerosis. Nutrition 1999, 15:744-748.
9. Hirst S.J., Barnes P.J., Twort C.H. PDGF isoform-induced proliferation and receptor expression in human cultured airway smooth muscle cells. Am. J. Physiol. 1996, 270:L415-L428.
10. Hirst S.J., Martin J.G., Bonacci J.V., Chan V., Fixman E.D., Hamid Q.A., Herszberg B., Lavoie J.P., McVicker C.G., Moir L.M., et al. Proliferative aspects of airway smooth muscle. J. Allergy Clin. Immunol. 2004, 114:S2-S17.
11. Jaiswal A.S., Narayan S. Zinc stabilizes adenomatous polyposis coli (APC) protein levels and induces cell cycle arrest in colon cancer cells. J. Cell. Biochem. 2004, 93:345-357.
12. Kelleher M.D., Abe M.K., Chao T.S., Jain M., Green J.M., Solway J., Rosner M.R., Hershenson M.B. Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis. Am. J. Physiol. 1995, 268:L894-L901.
13. Khaldi F., Bahri R., Zouari S. Acute severe asthma in infants. Study of 34 cases. Tunis. Med. 2003, 81:715-720.
14. Lang C., Murgia C., Leong M., Tan L.W., Perozzi G., Knight D., Ruffin R., Zalewski P. Anti-inflammatory effects of zinc and alterations in zinc transporter mRNA in mouse models of allergic inflammation. Am. J. Physiol. Lung Cell. Mol. Physiol. 2007, 292:L577-L584.
15. Liang J.Y., Liu Y.Y., Zou J., Franklin R.B., Costello L.C., Feng P. Inhibitory effect of zinc on human prostatic carcinoma cell growth. Prostate 1999, 40:200-207.
16. Murgia C., Lang C.J., Truong-Tran A.Q., Grosser D., Jayaram L., Ruffin R.E., Perozzi G., Zalewski P.D. Zinc and its specific transporters as potential targets in airway disease. Curr. Drug Targets 2006, 7:607-627.
17. Novick S.G., Godfrey J.C., Pollack R.L., Wilder H.R. Zinc-induced suppression of inflammation in the respiratory tract, caused by infection with human rhinovirus and other irritants. Med. Hypotheses 1997, 49:347-357.
18. Paramanantham R., Bay B.H., Sit K.H. Flow cytometric evaluation of the DNA profile and cell cycle of zinc supplemented human Chang liver cells. Acta Paediatr. Jpn. 1996, 38:334-338.
19. Pauwels R.A., Lofdahl C.G., Postma D.S., Tattersfield A.E., O'Byrne P., Barnes P.J., Ullman A. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N. Engl. J. Med. 1997, 337:1405-1411.
20. Powell S.R. The antioxidant properties of zinc. J. Nutr. 2000, 130:1447S-1454S.
21. Prasad A.S. Effects of zinc deficiency on Th1 and Th2 cytokine shifts. J. Infect. Dis. 2000, 182(Suppl. 1):S62-S68.
22. Shih R.S., Wong S.H., Schoene N.W., Lei K.Y. Suppression of Gadd45 alleviates the G2/M blockage and the enhanced phosphorylation of p53 and p38 in zinc supplemented normal human bronchial epithelial cells. Exp. Biol. Med. (Maywood) 2008, 233:317-327.
23. Soutar A., Seaton A., Brown K. Bronchial reactivity and dietary antioxidants. Thorax 1997, 52:166-170.
24. Stewart A.G., Grigoriadis G., Harris T. Mitogenic actions of endothelin-1 and epidermal growth factor in cultured airway smooth muscle. Clin. Exp. Pharmacol. Physiol. 1994, 21:277-285.
25. Tahan F., Karakukcu C. Zinc status in infantile wheezing. Pediatr. Pulmonol. 2006, 41:630-634.
26. Truong-Tran A.Q., Grosser D., Ruffin R.E., Murgia C., Zalewski P.D. Apoptosis in the normal and inflamed airway epithelium: role of zinc in epithelial protection and procaspase-3 regulation. Biochem. Pharmacol. 2003, 66:1459-1468.
27. Truong-Tran A.Q., Ho L.H., Chai F., Zalewski P.D. Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death. J. Nutr. 2000, 130:1459S-1466S.
28. Truong-Tran A.Q., Ruffin R.E., Foster P.S., Koskinen A.M., Coyle P., Philcox J.C., Rofe A.M., Zalewski P.D. Altered zinc homeostasis and caspase-3 activity in murine allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 2002, 27:286-296.
29. Velden V.H., Versnel H.F. Bronchial epithelium: morphology, function and pathophysiology in asthma. Eur. Cytokine Netw. 1998, 9:585-597.
30. Wu W., Wang X., Zhang W., Reed W., Samet J.M., Whang Y.E., Ghio A.J. Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells. J. Biol. Chem. 2003, 278:28258-28263.