Development of diclofenac sodium-loaded alginate-PVP K 30 microbeads using central composite design

DARU, Journal of Pharmaceutical Sciences

Volumn 19, Issue 5, 2011, Pages 356-366

  Nayak, A K ^a   Khatua, S ^a   Hasnain, M S ^a   Sen, K K ^b  

^a SEEMANTA INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

^b GUPTA COLLEGE OF TECHNOLOGICAL SCIENCES   (India)

Author keywords

Controlled release; FTIR; Ionotropic gelation; Optimization; Polymer blend

Indexed keywords

ALGINIC ACID; CARBON; DICLOFENAC; HYDROGEN; OXYGEN; POVIDONE;

ARTICLE; COMPOSITE MATERIAL; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG RELEASE; DRUG SYNTHESIS; GELATION; HYDROGEN BOND; IN VITRO STUDY; INFRARED SPECTROSCOPY; PARTICLE SIZE; PROCESS OPTIMIZATION; SCANNING ELECTRON MICROSCOPY;

EID: 84455199556     PISSN: 15608115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. George M, Abraham TE. Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan- a review. J. Control. Release. 2006; 114: 1-14.
2. Dhanaraju MD, Sundar VD, Nandhakumar S, Bhaskar K. Development and evaluation of sustained delivery of diclofenac sodium from hydrophilic polymeric beads. J. Young Pharm. 2009; 1: 301-304.
3. González-Rodríguez ML, Holgado MA, Sánchez-Lafuente C, Rabasco AM, Fini A. Alginate/chitosan particulate systems for sodium diclofenac release. Int. J. Pharm. 2002; 232: 225-234.
4. Patel YL, Sher P, Pawar A. The effect of drug concentration and curing time on processing and properties of calcium alginate beads containing metronidazole by response surface methodology. AAPS PharmSciTech. 2006; 7: E1-E7.
5. Smrdel P, Bogataj M, Mrhar A. The influence of selected parameters on the size and shape of alginate beads prepared by ionotropic gelation. Sci. Pharm. 2008; 76: 77-89.
6. Deshmukh VN, Sakarkar DM, Wakade RD. Formulation and evaluation of controlled release alginate microspheres using locust bean gum. J. Pharm. Res. 2009; 2: 258-261.
7. Manjanna KM, Shivakumar B, Pramod Kumar TM. Diclofenac sodium microbeads for oral sustained drug delivery, Int. J. PharmTech Res. 2009; 1: 317-327.
8. Deshmukh VN, Jadhav JK, Masirkar VJ, Sakarkar DM. Formulation, optimization and evaluation of controlled release alginate microspheres using synergy gum blends. Res. J. Pharm. Tech. 2009; 2; 324-327.
9. Krishna Rao KSV, Subha MCS, Naidu BVK, Sairam M, Mallikarjuna NN, Aminabhavi TN. Controlled release of diclofenac sodium and ibuprofen through beads of sodium alginate and hydroxy ethylcellulose blends. J. Appl. Polym. Sci. 2006; 102: 5708-5718.
10. Sanli O, Ay N, Işiklan N. Release characteristics of diclofenac sodium from poly (vinyl alcohol)/sodium alginate and poly (vinyl alcohol)-grafted-poly (acrylamide)/sodium alginate blend beads. Eur. J. Pharm. Biopharm. 2007; 65: 204-214.
11. Ye G, Wang S, Heng PWS, Chen L, Wang C. Development and optimization of solid dispersion containing pellets of itraconazole prepared by high shear pelletization. Int. J. Pharm. 2007; 337: 80-87.
12. Peppas NA. Analysis of Fickian and non Fickian drug release from polymers. Pharm. Acta Health. 1985; 60:110-111.
13. Peppas NA, Koresmeyer RW. Dynamically swelling hydrogels in controlled released applications. In: Peppas NA, ed. Hydrogels in Medicine and Pharmacy, 3rd Edn, CRC Press, Boca Raton. 1986: 109-136.
14. Gaudio P, Colombo P, Colombo G, Russo P, Sonvico F. Mechanisms of formation and disintegration of alginate beads obtained by prilling. Int. J. Pharm. 2005; 302: 1-9.
15. Ostberg T, Graffner C. Calcium alginate matrices or oral multiple unit administration: II Influence of calcium concentration, amount of drug added and alginate characteristics on drug release. Int. J. Pharm. 1994; 111: 271-282.