Favourable prognosis in medulloblastoma with extensive nodularity is associated with mitogen-activated protein kinase upregulation

Folia Neuropathologica

Volumn 49, Issue 4, 2011, Pages 257-261

  Jóźwiak, Jarosław ^a   Sontowska, Iwona ^a   Bikowska, Barbara ^a   Grajkowska, Wiesałwa ^b,c   Galus, Ryszard ^a   Roszkowski, Marcin ^b  

^a MEDICAL UNIVERSITY OF WARSAW   (Poland)

^b CHILDREN'S MEMORIAL HEALTH INSTITUTE   (Poland)

^c MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

Author keywords

Medulloblastoma with extensive nodularity; Mitogen activated protein kinase; mTor

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE B; S6 KINASE; SOMATOMEDIN C;

ARTICLE; CANCER GROWTH; CARCINOGENESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MEDULLOBLASTOMA; MEDULLOBLASTOMA WITH EXTENSIVE NODULARITY; PROGNOSIS; PROTEIN PHOSPHORYLATION; UPREGULATION; WESTERN BLOTTING;

EID: 84455193867     PISSN: 16414640     EISSN: 1509572X     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Aliani S, Brunner J, Graf N, Altmeyer K, Niedermayer I, Strowitzki M. Medulloblastoma with extensive nodularity in nevoid basal cell carcinoma syndrome. Med Pediatr Oncol 2003; 40: 266-267. (Pubitemid 36222839)
2. Bekiesińska-Figatowska M, Jurkiewicz E, Uliasz M, Mazurczak T, Barszcz S, Grajkowska W, Roszkowski M. Medulloblastoma with extensive nodularity: US, CT and MRI findings. Pol J Radiol 2008; 73: 32-35.
3. Chelliah D, Mensah Sarfo-Poku C, Stea BD, Gardetto J, Zumwalt J. Medulloblastoma with extensive nodularity undergoing posttherapeutic maturation to a gangliocytoma: a case report and literature review. Pediatr Neurosurg 2010; 46: 381-384.
4. Giangaspero F, Perilongo G, Fondelli MP, Brisigotti M, Carollo C, Burnelli R, Burger PC, Garré ML. Medulloblastoma with extensive nodularity: a variant with favorable prognosis. J Neurosurg 1999; 91: 971-977.
5. Huang H, Mahler-Araujo BM, Sankila A, Chimelli L, Yonekawa Y, Kleihues P, Ohgaki H. APC mutations in sporadic medulloblastomas. Am J Pathol 2000; 156: 433-437. (Pubitemid 30643798)
6. Jóźwiak J, Bikowska B, Grajkowska W, Sontowska I, Roszkowski M, Galus R. Activation of Akt/mTOR pathway in a patientwith atypical teratoid/rhabdoid tumor. Folia Neuropathol 2010; 48: 185-189.
7. Jozwiak J, Grajkowska W, Kotulska K, Jozwiak S, Zalewski W, Zaja czkowska A, Roszkowski M, Slupianek A, Wlodarski P. Brain tumor formation in tuberous sclerosis depends on Erk activation. Neuromolecular Med 2007; 9: 117-127. (Pubitemid 47065540)
8. Louis ND, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification of Tumours of the Central Nervous System (3rd Edition). IARC, Lyon 2007; pp. 132-140.
9. McManamy CS, Pears J, Weston CL, Hanzely Z, Ironside JW, Taylor RE, Grundy RG, Clifford SC, Ellison DW; Clinical Brain Tu - mour Group. Nodule formation and desmoplasia in medulloblastomas - defining the nodular/desmoplastic variant and its biological behaviour. Brain Pathol 2007; 17: 151-164. (Pubitemid 46466135)
10. Packer RJ. Chemotherapy for medulloblastoma/primitive neuro ectodermal tumors of the posterior fossa. Ann Neurol 1990; 28: 823-828.
11. Patti R, Reddy CD, Geoerger B, Grotzer MA, Raghunath M, Sutton LN, Phillips PC. Autocrine secreted insulin-like growth factor- I stimulates MAP kinase-dependent mitogenic effects in human primitive neuroectodermal tumor/medulloblastoma. Int J Oncol 2000; 16: 577-584.
12. Roach ES, Sparagana SP. Diagnosis of tuberous sclerosis complex. J Child Neurol 2004; 19: 643-649. (Pubitemid 39530072)
13. Suresh TN, Santosh V, Yasha TC, Anandh B, Mohanty A, Indiradevi B, Sampath S, Shankar SK. Medulloblastoma with extensive nodularity: a variant occurring in the very young - clinicopathological and immunohistochemical study of four cases. Childs Nerv Syst 2004; 20: 55-60. (Pubitemid 38159291)
14. von Hoff K, Hartmann W, von Bueren AO, Gerber NU, Grot zer MA, Pietsch T, Rutkowski S. Large cell/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors. Pediatr Blood Cancer 2010; 54: 369-376.
15. Vorechovský I, Tingby O, Hartman M, Strömberg B, Nister M, Collins VP, Toftgård R. Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours. Oncogene 1997; 15: 361-366. (Pubitemid 27370882)
16. Wlodarski PK, Boszczyk A, Grajkowska W, Roszkowski M, Jozwiak J. Implication of active Erk in the classic type of human medulloblastoma. Folia Neuropathol 2008; 46: 117-122.
17. Yokota N, Nishizawa S, Ohta S, Date H, Sugimura H, Namba H, Maekawa M. Role of Wnt pathway in medulloblastoma oncogenesis. Int J Cancer 2002; 101: 198-201. (Pubitemid 34970914)