Choline phosphorylation and regulation of transcription of choline kinase α in hypoxia

Journal of Lipid Research

Volumn 53, Issue 1, 2012, Pages 149-157

  Bansal, Aditya ^a,b   Harris, Robert A ^b   DeGrado, Timothy R ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

Cancer; Gene expression; Lipid kinases; Phospholipids metabolism; Phospholipids phosphatidylcholine

Indexed keywords

CHOLINE; CHOLINE KINASE; CHOLINE KINASE ALPHA; GENOMIC DNA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CANCER CELL; CELL HYPOXIA; CHOLINE KINASE ALPHA GENE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA BINDING MOTIF; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HYPOXIA RESPONSE ELEMENT 7; PHOSPHORYLATION; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; TRANSLATION INITIATION; TRANSLATION INITIATION SITE;

BASE SEQUENCE; CELL HYPOXIA; CELL LINE, TUMOR; CHOLINE; CHOLINE KINASE; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC;

EID: 84455188824     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M021030     Document Type: Article

References (30)

1. Kent, C. 2005. Regulatory enzymes of phosphatidylcholine biosynthesis: a personal perspective. Biochim. Biophys. Acta. 1733: 53-66. (Pubitemid 40321171)
2. DeGrado, T. R., R. E. Coleman, S. Wang, S. W. Baldwin, M. D. Orr, C. N. Robertson, T. J. Polascik, and D. T. Price. 2001. Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer. Cancer Res. 61: 110-117. (Pubitemid 32095708)
3. Katz-Brull, R., D. Seger, D. Rivenson-Segal, E. Rushkin, and H. Degani. 2002. Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis. Cancer Res. 62: 1966-1970. (Pubitemid 34408439)
4. Katz-Brull, R., and H. Degani. 1996. Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method. Anticancer Res. 16: 1375-1380.
5. Hara, T., N. Kosaka, and H. Kishi. 2002. Development of (18) F-fluoroethylcholine for cancer imaging with PET: synthesis, biochemistry, and prostate cancer imaging. J. Nucl. Med. 43: 187-199. (Pubitemid 34151041)
6. Ramírez de Molina, A., D. Gallego-Ortega, J. Sarmentero-Estrada, D. Lagares, T. Gómez Del Pulgar, E. Bandrés, J. García-Foncillas, and J. C. Lacal. 2008. Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy. Int. J. Biochem. Cell Biol. 40: 1753-1763.
7. Talbot, J. N., F. Gutman, L. Fartoux, J. D. Grange, N. Ganne, K. Kerrou, D, Grahek, F. Montravers, R. Poupon, and O. Rosmorduc. 2006. PET/CT in patients with hepatocellular carcinoma using [(18)F]fluorocholine: preliminary comparison with [(18)F]FDG PET/CT. Eur. J. Nucl. Med. Mol. Imaging. 33: 1285-1289. (Pubitemid 44630783)
8. Kwee, S. A., H. Wei, I. Sesterhenn, D. Yun, and M. N. Coel. 2006. Localization of primary prostate cancer with dual-phase 18F-fluorocholine PET. J. Nucl. Med. 47: 262-269. (Pubitemid 46780891)
9. Sarri, E., D. Garcia-Dorado, A. Abellan, and J. Soler-Soler. 2006. Effects of hypoxia, glucose deprivation and acidosis on phosphatidylcholine synthesis in HL-1 cardiomyocytes. CTP:phosphocholine cytidylyltransferase activity correlates with sarcolemmal disruption. Biochem. J. 394: 325-334. (Pubitemid 43259682)
10. Bansal, A., W. Shuyan, T. Hara, R. A. Harris, and T. R. Degrado. 2008. Biodisposition and metabolism of [(18)F]fluorocholine in 9L glioma cells and 9L glioma-bearing fisher rats. Eur. J. Nucl. Med. Mol. Imaging. 35: 1192-1203.
11. Hara, T., A. Bansal, and T. R. DeGrado. 2006. Effect of hypoxia on the uptake of [methyl-3H]choline, [1-14C] acetate and [18F]FDG in cultured prostate cancer cells. Nucl. Med. Biol. 33: 977-984. (Pubitemid 44791951)
12. Allen, C. B., B. K. Schneider, and C. W. White. 2001. Limitations to oxygen diffusion and equilibration in in vitro cell exposure systems in hyperoxia and hypoxia. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L1021-L1027.
13. Gurantz, D., M. F. Laker, and A. F. Hofmann. 1981. Enzymatic measurement of choline-containing phospholipids in bile. J. Lipid Res. 22: 373-376. (Pubitemid 11125140)
14. Murray, J. J., T. T. Dinh, A. P. Truett 3rd, and D. A. Kennerly. 1990. Isolation and enzymic assay of choline and phosphocholine present in cell extracts with picomole sensitivity. Biochem. J. 270: 63-68. (Pubitemid 20275576)
15. Infante, J. P. 1977. Rate-limiting steps in the cytidine pathway for the synthesis of phosphatidylcholine and phosphatidylethanolamine. Biochem. J. 167: 847-849. (Pubitemid 8241004)
16. Guynn, R. W. 1976. Equilibrium constants under physiological conditions for the reactions of choline kinase and the hydrolysis of phosphorylcholine to choline and inorganic phosphate. J. Biol. Chem. 251: 7162-7167. (Pubitemid 8020855)
17. Xia, X., and A. L. Kung. 2009. Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia. Genome Biol. 10: R113.
18. Xia, X., M. E. Lemieux, W. Li, J. S. Carroll, M. Brown, X. S. Liu, and A. L. Kung. 2009. Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proc. Natl. Acad. Sci. USA. 106: 4260-4265.
19. Glunde, K., T. Shah, P. T. Winnard, Jr., V. Raman, T. Takagi, F. Vesuna, D. Artemov, and Z. M. Bhujwalla. 2008. Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model. Cancer Res. 68: 172-180. (Pubitemid 351380118)
20. Uchida, T. 1994. Regulation of choline kinase R: analyses of alternatively spliced choline kinases and the promoter region. J. Biochem. 116: 508-518. (Pubitemid 24294776)
21. Boucher, Y., I. Lee, and R. K. Jain. 1995. Lack of general correlation between interstitial fluid pressure and oxygen partial pressure in solid tumors. Microvasc. Res. 50: 175-182.
22. Cárdenas-Navia, L. I., D. Yu, R. D. Braun, D. M. Brizel, T. W. Secomb, and M. W. Dewhirst. 2004. Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing. Cancer Res. 64: 6010-6017. (Pubitemid 39129398)
23. Braun, R. D., J. L. Lanzen, S. A. Snyder, and M. W. Dewhirst. 2001. Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. Am. J. Physiol. Heart Circ. Physiol. 280: H2533-H2544.
24. Aoyama, C., H. Liao, and K. Ishidate. 2004. Structure and function of choline kinase isoforms in mammalian cells. Prog. Lipid Res. 43: 266-281. (Pubitemid 38299195)
25. Heerlein, K., A. Schulze, L. Hotz, P. Bartsch, and H. Mairbaurl. 2005. Hypoxia decreases cellular ATP demand and inhibits mitochondrial respiration of a549 cells. Am. J. Respir. Cell Mol. Biol. 32: 44-51. (Pubitemid 40053303)
26. Vander Heiden, M. G., L. C. Cantley, and C. B. Thompson. 2009. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 324: 1029-1033.
27. Izyumov, D. S., A. V. Avetisyan, O. Y. Pletjushkina, D. V. Sakharov, K. W. Wirtz, B. V. Chernyak, and V. P. Skulachev. 2004. "Wages of fear": transient threefold decrease in intracellular ATP level imposes apoptosis. Biochim. Biophys. Acta. 1658: 141-147. (Pubitemid 39013244)
28. Elvidge, G. P., L. Glenny, R. J. Appelhoff, P. J. Ratcliffe, J. Ragoussis, and J. M. Gleadle. 2006. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J. Biol. Chem. 281: 15215-15226. (Pubitemid 43855111)
29. Caro, J. 2001. Hypoxia regulation of gene transcription. High Alt. Med. Biol. 2: 145-154. (Pubitemid 32677853)
30. Okino, S. T., C. H. Chichester, and J. P. Whitlock, Jr. 1998. Hypoxia-inducible mammalian gene expression analyzed in vivo at a TATA-driven promoter and at an initiator-driven promoter. J. Biol. Chem. 273: 23837-23843. (Pubitemid 28435719)