Apoptosis and autoimmunity as proposed pathogenetic links between Helicobacter pylori infection and idiopathic achalasia

Medical Hypotheses

Volumn 63, Issue 4, 2004, Pages 624-629

  Kountouras, Jannis ^a,b   Zavos, Christos ^a   Chatzopoulos, Dimitrios ^a  

^a Ippokration Hospital Thessaloniki   (Greece)

^b Greece ^*  (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AUTOANTIBODY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR;

ANTIGEN ANTIBODY COMPLEX; ANTIGEN EXPRESSION; APOPTOSIS; AUTOIMMUNITY; BACTERIAL INFECTION; CAMPYLOBACTER JEJUNI; CANCER RISK; CELL FUNCTION; CROSS REACTION; DISEASE MARKER; ERADICATION THERAPY; ESOPHAGUS ACHALASIA; ESOPHAGUS DISEASE; GENE LOCUS; GUILLAIN BARRE SYNDROME; HAPLOTYPE; HELICOBACTER PYLORI; HEREDITY; HLA SYSTEM; IMMUNE RESPONSE; LOWER ESOPHAGUS SPHINCTER PRESSURE; MYENTERIC PLEXUS; NERVE CELL; NERVE DEGENERATION; NERVE FIBER; NERVE INJURY; PARKINSON DISEASE; PATHOGENESIS; PATHOPHYSIOLOGY; PERIPHERAL NEUROPATHY; PERISTALSIS; PRIORITY JOURNAL; REVIEW; RISK FACTOR; STOMACH MUCOSA; VIRUS;

HELICOBACTER; HELICOBACTER PYLORI;

EID: 8444236996     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.04.003     Document Type: Article

References (37)

1. Raymond L., Lach B., Shamji F.M. Inflammatory aetiology of primary oesophageal achalasia: an immunohistochemical and ultrastructural study of Auerbach's plexus. Histopathology. 35:1999;445-453
2. Moses P.L., Ellis L.M., Anees M.R., et al. Antineuronal antibodies in idiopathic achalasia and gastro-oesophageal reflux disease. Gut. 52:2003;629-636
3. Clouse RE, Diamant NE. Esophageal motor and sensory function and motor disorders of the esophagus. In: Sleisenger MH, Fordtran JS, editors. Gastrointestinal and liver disease. 7th ed. Saunders: Philadelphia; 2003. p. 561-98
4. Mullaney P.B., Weatherhead R., Millar L., et al. Keratoconjunctivitis sicca associated with achalasia of the cardia, adrenocortical insufficiency, and lacrimal gland degeneration: keratoconjunctivitis sicca secondary to lacrimal gland degeneration may parallel degenerative changes in esophageal and adrenocortical function. Ophthalmology. 105:1998;643-650
5. Storch W.B., Eckardt V.F., Wienbeck M., et al. Autoantibodies to Auerbach's plexus in achalasia. Cell Mol. Biol. (Noisy-le-grand). 41:1995;1033-1038
6. Firouzi M., Keshavarzian A. Guillain-Barre syndrome and achalasia: two manifestations of a viral disease or coincidental association? Am. J. Gastroenterol. 89:1994;1585-1587
7. Johnston B.T., Colcher A., Li Q., Gideon R.M., Castell J.A., Castell D.O. Repetitive proximal esophageal contractions: a new manometric finding and a possible further link between Parkinson's disease and achalasia. Dysphagia. 16:2001;186-189
8. Ariga T., Jarvis W.D., Yu R.K. Role of sphingolipid-mediated cell death in neurodegenerative diseases. J. Lipid Res. 39:1998;1-16
9. Saporito M.S., Hudkins R.L., Maroney A.C. Discovery of CEP-1347/KT-7515, an inhibitor of the JNK/SAPK pathway for the treatment of neurodegenerative diseases. Prog. Med. Chem. 40:2002;23-62
10. Parente F., Negrini R., Imbesi V., et al. Presence of gastric autoantibodies impairs gastric secretory function in patients with Helicobacter pylori-positive duodenal ulcer. Scand. J. Gastroenterol. 36:2001;474-478
11. Croinin T.O., Clyne M., Appelmelk B.J., et al. Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae. Infect. Immun. 69:2001;2708-2713
12. Vorobjova T., Faller G., Maaroos H.I., et al. Significant increase in antigastric autoantibodies in a long-term follow-up study of H. pylori gastritis. Virchows Arch. 437:2000;37-45
13. Archimandritis A., Sougioultzis S., Foukas P.G., et al. Expression of HLA-DR, costimulatory molecules B7-1, B7-2, intercellular adhesion molecule-1 (ICAM-1) and Fas ligand (FasL) on gastric epithelial cells in Helicobacter pylori gastritis; influence of H. pylori eradication. Clin. Exp. Immunol. 119:2000;464-471
14. Wee A., Teh M., Kang J.Y. Association of Helicobacter pylori with HLA-DR antigen expression in gastritis. Clin. Pathol. 45:1992;30-33
15. Chiba S., Sugiyama T., Matsumoto H., et al. Antibodies against Helicobacter pylori were detected in the cerebrospinal fluid obtained from patients with Guillain-Barre syndrome. Ann. Neurol. 44:1998;686-688
16. Kornberg A.J., Pestronk A. Immune-mediated neuropathies. Curr. Opin. Neurol. 6:1993;681-687
17. Chiba S., Sugiyama T., Yonekura K., et al. An antibody to VacA of Helicobacter pylori in cerebrospinal fluid from patients with Guillain-Barre syndrome. J. Neurol. Neurosurg. Psychiatry. 73:2002;76-78
18. Kountouras J., Zavos C., Chatzopoulos D. Induction of apoptosis as a proposed pathophysiological link between glaucoma and Helicobacter pylori infection. Med. Hypotheses. 62:2004;378-381
19. Debas H.T., Mulvihill S.J. Neuroendocrine design of the gut. Am. J. Surg. 161:1991;243-249
20. Csendes A., Smok G., Braghetto I., Ramirez C., Velasco N., Henriquez A. Gastroesophageal sphincter pressure and histological changes in distal esophagus in patients with achalasia of the esophagus. Dig. Dis. Sci. 30:1985;941-945
21. Clark S.B., Rice T.W., Tubbs R.R., Richter J.E., Goldblum J.R. The nature of the myenteric infiltrate in achalasia: an immunohistochemical analysis. Am. J. Surg. Pathol. 24:2000;1153-1158
22. Cassella R.R., Brown A.L. Jr., Sayre G.P., Ellis F.H. Jr. Achalasia of the esophagus: pathologic and etiologic considerations. Ann. Surg. 160:1964;474-487
23. Kountouras J., Kouklakis G., Zavos C., et al. Apoptosis, inflammatory bowel disease and carcinogenesis: overview of international and Greek experiences. Can. J. Gastroenterol. 17:2003;249-258
24. Kountouras J., Zavos C., Chatzopoulos D. Apoptosis in hepatitis C. J. Viral Hepat. 10:2003;335-342
25. Verne G.N., Hahn A.B., Pineau B.C., Hoffman B.J., Wojciechowski B.W., Wu W.C. Association of HLA-DR and -DQ alleles with idiopathic achalasia. Gastroenterology. 117:1999;26-31
26. de la Concha E.G., Fernandez-Arquero M., Conejero L., Lazaro F., et al. Presence of a protective allele for achalasia on the central region of the major histocompatibility complex. Tissue Antigens. 56:2000;149-153
27. Sterin-Borda L., Borda E. Role of neurotransmitter autoantibodies in the pathogenesis of chagasic peripheral dysautonomia. Ann. NY Acad. Sci. 917:2000;273-280
28. Saur D., Paehge H., Schusdziarra V., Allescher H.D. Distinct expression of splice variants of neuronal nitric oxide synthase in the human gastrointestinal tract. Gastroenterology. 118:2000;849-858
29. Kountouras J., Mylopoulos N., Boura P., et al. Relationship between Helicobacter pylori infection and glaucoma. Ophthalmology. 108:2001;599-604
30. Kountouras J., Mylopoulos N., Chatzopoulos D., et al. Eradication of Helicobacter pylori may be beneficial in the management of chronic open-angle glaucoma. Arch. Intern. Med. 162:2002;1237-1244
31. Kountouras J, Zavos C, Chatzopoulos D. Apoptosis: an overview and a proposed link between glaucoma and Helicobacter pylori infection. In: Progress in Glaucoma Research. 1st ed. New York: Nova Science Publishers, Inc.; 2004 [in press]
32. Chen W., Shu D., Wilson I.R., et al. Rapid elimination of Helicobacter pylori and reduction of histocompatibility leucocyte antigen-DR expression 12 h after a single dose of omeprazole, amoxycillin and metronidazole triple therapy. J. Gastroenterol. Hepatol. 14:1999;322-327
33. Kountouras J., Mylopoulos N., Konstas A.G., Zavos C., Chatzopoulos D., Boukla A. Increased levels of Helicobacter pylori IgG antibodies in aqueous humor of patients with primary open-angle and exfoliation glaucoma. Graefes Arch. Clin. Exp. Ophthalmol. 241:2003;884-890
34. Faller G., Kirchner T. Role of antigastric autoantibodies in chronic Helicobacter pylori infection. Microsc. Res. Tech. 48:2000;321-326
35. Faller G., Steininger H., Appelmelk B., et al. Evidence of novel pathogenic pathways for the formation of antigastric autoantibodies in Helicobacter pylori gastritis. J. Clin. Pathol. 51:1998;244-245
36. Vandenbroucke-Grauls C.M., Appelmelk B.J. Helicobacter pylori LPS: molecular mimicry with the host and role in autoimmunity. Ital. J. Gastroenterol. Hepatol. 30(Suppl 3):1998;S259-S260
37. Moran A.P., Prendergast M.M. Molecular mimicry in Campylobacter jejuni and Helicobacter pylori lipopolysaccharides: contribution of gastrointestinal infections to autoimmunity. J. Autoimmun. 16:2001;241-256