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Volumn 21, Issue 13, 2004, Pages 885-892

Darifenacin: In the treatment of overactive bladder

Author keywords

[No Author keywords available]

Indexed keywords

DARIFENACIN; MUSCARINIC M3 RECEPTOR ANTAGONIST; OXYBUTYNIN; TOLTERODINE;

EID: 8444235987     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200421130-00005     Document Type: Review
Times cited : (12)

References (44)
  • 1
    • 0036186813 scopus 로고    scopus 로고
    • The standardisation of terminology of lower urinary tract function: Report from the Standardisation Sub-Committee of the International Continence Society
    • Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-Committee of the International Continence Society. Neurourol Urodyn 2002; 21: 167-78
    • (2002) Neurourol Urodyn , vol.21 , pp. 167-178
    • Abrams, P.1    Cardozo, L.2    Fall, M.3
  • 2
    • 0035725404 scopus 로고    scopus 로고
    • How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study
    • Milsom I, Abrams P, Cardozo L, et al. How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int 2001; 87: 760-6
    • (2001) BJU Int , vol.87 , pp. 760-766
    • Milsom, I.1    Abrams, P.2    Cardozo, L.3
  • 3
    • 0141566431 scopus 로고    scopus 로고
    • Prevalence and burden of overactive bladder in the United States
    • Stewart WF, Van Rooyen JB, Cundiff GW, et al. Prevalence and burden of overactive bladder in the United States. World J Urol 2003; 20: 327-36
    • (2003) World J Urol , vol.20 , pp. 327-336
    • Stewart, W.F.1    Van Rooyen, J.B.2    Cundiff, G.W.3
  • 4
    • 0346250806 scopus 로고    scopus 로고
    • Antimuscarinics for treatment of overactive bladder
    • Andersson K-E. Antimuscarinics for treatment of overactive bladder. Lancet Neurology 2004; 3 (1): 46-53
    • (2004) Lancet Neurology , vol.3 , Issue.1 , pp. 46-53
    • Andersson, K.-E.1
  • 5
    • 0002491968 scopus 로고
    • Darifenacin, a selective muscarinic M-3 antagonist
    • Wallis RM, Burges RA, Cross PE, et al. Darifenacin, a selective muscarinic M-3 antagonist [abstract]. Pharmacol Res 1995; 31 Suppl.: 54
    • (1995) Pharmacol Res , vol.31 , Issue.SUPPL. , pp. 54
    • Wallis, R.M.1    Burges, R.A.2    Cross, P.E.3
  • 6
    • 0013640165 scopus 로고    scopus 로고
    • The binding profile on the novel muscarinic receptor antagonist darifenacin against the five cloned human muscarinic receptors expressed in CHO cells
    • Apr
    • Nunn PA, Greengrass PM, Newgreen DT, et al. The binding profile on the novel muscarinic receptor antagonist darifenacin against the five cloned human muscarinic receptors expressed in CHO cells [abstract no. 130P]. Br J Pharmacol 1996 Apr; 117 Suppl.
    • (1996) Br J Pharmacol , vol.117 , Issue.SUPPL.
    • Nunn, P.A.1    Greengrass, P.M.2    Newgreen, D.T.3
  • 7
    • 8244228668 scopus 로고    scopus 로고
    • Characterization of the interaction of darifenacin at muscarinic receptor subtypes in vitro
    • Jul
    • Eglen RM, Pulido-Rios MT, Webber AP, et al. Characterization of the interaction of darifenacin at muscarinic receptor subtypes in vitro [abstract no. 35P]. Br J Pharmacol 1996 Jul; 118 Suppl.
    • (1996) Br J Pharmacol , vol.118 , Issue.SUPPL.
    • Eglen, R.M.1    Pulido-Rios, M.T.2    Webber, A.P.3
  • 8
    • 0030614423 scopus 로고    scopus 로고
    • Characterisation of [3H]-darifenacin as a novel radioligand for the study of muscarinic M3 receptors
    • Smith CM, Wallis RM. Characterisation of [3H]-darifenacin as a novel radioligand for the study of muscarinic M3 receptors. J Recept Signal Transduct Res 1997; 17 (1-3): 177-84
    • (1997) J Recept Signal Transduct Res , vol.17 , Issue.1-3 , pp. 177-184
    • Smith, C.M.1    Wallis, R.M.2
  • 10
    • 0032557686 scopus 로고    scopus 로고
    • Comparison of the in vitro and in vivo profiles of tolterodine with those of subtype-selective muscarinic receptor antagonists
    • May 22
    • Gillberg PG, Sundquist S, Nilvebrant L. Comparison of the in vitro and in vivo profiles of tolterodine with those of subtype-selective muscarinic receptor antagonists. Eur J Pharmacol 1998 May 22; 349 (2-3): 285-92
    • (1998) Eur J Pharmacol , vol.349 , Issue.2-3 , pp. 285-292
    • Gillberg, P.G.1    Sundquist, S.2    Nilvebrant, L.3
  • 11
    • 4243148476 scopus 로고    scopus 로고
    • Functional selectivity of muscarinic receptor antagonists for inhibition of M3-mediated phosphoinositide responses in guinea-pig urinary bladder and submandibular salivary gland
    • May 12
    • Nelson CP, Gupta P, Napier CM, et al. Functional selectivity of muscarinic receptor antagonists for inhibition of M3-mediated phosphoinositide responses in guinea-pig urinary bladder and submandibular salivary gland. J Pharmacol Exp Ther 2004 May 12
    • (2004) J Pharmacol Exp Ther
    • Nelson, C.P.1    Gupta, P.2    Napier, C.M.3
  • 12
    • 2642569156 scopus 로고    scopus 로고
    • In vitro and in vivo tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats
    • May 25
    • Ohtake A, Ukai M, Hatanaka T, et al. In vitro and in vivo tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats. Eur J Pharmacol 2004 May 25; 492 (2-3): 243-50
    • (2004) Eur J Pharmacol , vol.492 , Issue.2-3 , pp. 243-250
    • Ohtake, A.1    Ukai, M.2    Hatanaka, T.3
  • 13
    • 0033534541 scopus 로고    scopus 로고
    • Muscarinic antagonists in development for disorders of smooth muscle function
    • Wallis RM, Napier CM. Muscarinic antagonists in development for disorders of smooth muscle function. Life Sci 1999; 64 (6-7): 395-401
    • (1999) Life Sci , vol.64 , Issue.6-7 , pp. 395-401
    • Wallis, R.M.1    Napier, C.M.2
  • 14
    • 0344394920 scopus 로고    scopus 로고
    • Pharmacological effects of darifenacin on human isolated urinary bladder
    • Dec
    • Miyamae K, Yoshida M, Murakami S, et al. Pharmacological effects of darifenacin on human isolated urinary bladder. Pharmacology 2003 Dec; 69 (4): 205-11
    • (2003) Pharmacology , vol.69 , Issue.4 , pp. 205-211
    • Miyamae, K.1    Yoshida, M.2    Murakami, S.3
  • 15
    • 0002774274 scopus 로고    scopus 로고
    • Comparison of the functional muscarinic receptor selectivity of darifenacin with tolterodine and oxybutinin
    • Apr
    • Newgreen DT, Naylor AM. Comparison of the functional muscarinic receptor selectivity of darifenacin with tolterodine and oxybutinin [abstract no. 107P]. Br J Pharmacol 1996 Apr; 117 Suppl.
    • (1996) Br J Pharmacol , vol.117 , Issue.SUPPL.
    • Newgreen, D.T.1    Naylor, A.M.2
  • 16
    • 8844239350 scopus 로고    scopus 로고
    • Darifenacin has a low affinity for muscarinic M1 receptors in dog saphenous vein confirming its M3 selectivity
    • Alexandrou A, Claringbold A, Harris J, et al. Darifenacin has a low affinity for muscarinic M1 receptors in dog saphenous vein confirming its M3 selectivity [abstract no. 458]. Eur Urol Suppl 2003; 1: 117
    • (2003) Eur Urol Suppl , vol.1 , pp. 117
    • Alexandrou, A.1    Claringbold, A.2    Harris, J.3
  • 17
    • 0002772886 scopus 로고    scopus 로고
    • Characterisation of functional muscarinic receptors in human bladder
    • Oct
    • Newgreen DT, Naylor AM. Characterisation of functional muscarinic receptors in human bladder [abstract no. 45P]. Br J Pharmacol 1996 Oct; 119 Suppl.
    • (1996) Br J Pharmacol , vol.119 , Issue.SUPPL.
    • Newgreen, D.T.1    Naylor, A.M.2
  • 18
    • 0343274607 scopus 로고    scopus 로고
    • Effect of darifenacin on muscarinic responses in normal and unstable human detrusor smooth muscle cells
    • Chua CB, Harriss DR, Marsh KA, et al. Effect of darifenacin on muscarinic responses in normal and unstable human detrusor smooth muscle cells. Neurourol Urodyn 1997; 16: 355-6
    • (1997) Neurourol Urodyn , vol.16 , pp. 355-356
    • Chua, C.B.1    Harriss, D.R.2    Marsh, K.A.3
  • 19
    • 0000068279 scopus 로고    scopus 로고
    • The effects of darifenacin and oxybutynin on bladder function and salivation in the conscious rat
    • Mar
    • Williamson IJR, Newgreen DT, Naylor AM. The effects of darifenacin and oxybutynin on bladder function and salivation in the conscious rat [abstract no. 205P]. Br J Pharmacol 1997 Mar; 120 Suppl.
    • (1997) Br J Pharmacol , vol.120 , Issue.SUPPL.
    • Williamson, I.J.R.1    Newgreen, D.T.2    Naylor, A.M.3
  • 20
    • 3142619868 scopus 로고    scopus 로고
    • In vivo bladder selectivity of the novel muscarinic antagonist, darifenacin, in the conscious minipig
    • Apr
    • Davies CL, Dodd MG, Merner PA, et al. In vivo bladder selectivity of the novel muscarinic antagonist, darifenacin, in the conscious minipig [abstract no. 202P]. Br J Pharmacol 1996 Apr; 117 Suppl.
    • (1996) Br J Pharmacol , vol.117 , Issue.SUPPL.
    • Davies, C.L.1    Dodd, M.G.2    Merner, P.A.3
  • 21
    • 0011884156 scopus 로고    scopus 로고
    • Darifenacin, the first selective M3 antagonist for overactive bladder: Comparison with oxybutynin on ambulatory urodynamic monitoring and salivary flow
    • Sep 17-21; Seoul [online]. Available from URL
    • Mundy AR, Abrams P, Chapple CR, et al. Darifenacin, the first selective M3 antagonist for overactive bladder: comparison with oxybutynin on ambulatory urodynamic monitoring and salivary flow [abstract no. 221]. 31st Annual Meeting of the International Continence Society; 2001 Sep 17-21; Seoul [online]. Available from URL: http://www.icsoffice.org/publications [Accessed 2004 Aug 31]
    • (2001) 31st Annual Meeting of the International Continence Society
    • Mundy, A.R.1    Abrams, P.2    Chapple, C.R.3
  • 22
    • 1242301622 scopus 로고    scopus 로고
    • In vivo bladder selectivity of darifenacin, a new M3 antimuscarinic agent, in the anesthetised dog
    • Gupta P, Anderson C, Carter A, et al. In vivo bladder selectivity of darifenacin, a new M3 antimuscarinic agent, in the anesthetised dog [abstract no. 515]. Eur Urol 2002; 1 Suppl 1: 131
    • (2002) Eur Urol , vol.1 , Issue.SUPPL. 1 , pp. 131
    • Gupta, P.1    Anderson, C.2    Carter, A.3
  • 23
    • 0344247664 scopus 로고    scopus 로고
    • Darifenacin: A novel bladder-selective muscarinic antagonist for the treatment of urge incontinence
    • May
    • Newgreen DT, Anderson CWP, Carter TJ, et al. Darifenacin: a novel bladder-selective muscarinic antagonist for the treatment of urge incontinence [abstract no. 1156]. J Urol 1996 May; 155 Suppl.: 600A
    • (1996) J Urol , vol.155 , Issue.SUPPL.
    • Newgreen, D.T.1    Anderson, C.W.P.2    Carter, T.J.3
  • 24
    • 0034662903 scopus 로고    scopus 로고
    • Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype
    • Aug 15
    • Matsui M, Motomura D, Karasawa H, et al. Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci U S A 2000 Aug 15; 97 (17): 9579-84
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.17 , pp. 9579-9584
    • Matsui, M.1    Motomura, D.2    Karasawa, H.3
  • 25
    • 8444226860 scopus 로고    scopus 로고
    • The M3 selective receptor antagonist darifenacin has no clinically relevant effect on cognition and cardiac function
    • Kay G. The M3 selective receptor antagonist darifenacin has no clinically relevant effect on cognition and cardiac function [abstract no. 65]. Prog Urol 2004; 14 Suppl. 3: 22
    • (2004) Prog Urol , vol.14 , Issue.SUPPL. 3 , pp. 22
    • Kay, G.1
  • 26
    • 25144516369 scopus 로고    scopus 로고
    • Darifenacin, an M3 selective receptor antagonist for the treatment of overactive bladder, does not affect cognitive function in elderly volunteers
    • Mar 24-27; Vienna [online]. Available from URL
    • Wesnes K, Lipton R, Kolodner K, et al. Darifenacin, an M3 selective receptor antagonist for the treatment of overactive bladder, does not affect cognitive function in elderly volunteers [abstract no. 513]. 19th Congress of the European Society of Urology; 2004 Mar 24-27; Vienna [online]. Available from URL: http://www.uroweb.org [Accessed 2004 Jun 18]
    • (2004) 19th Congress of the European Society of Urology
    • Wesnes, K.1    Lipton, R.2    Kolodner, K.3
  • 27
    • 0345374663 scopus 로고    scopus 로고
    • Population pharmacokinetic modelling of darifenacin and its hydroxylated metabolite using pooled data, incorporating saturable first-pass metabolism, CYP2D6 genotype and formulation-dependent bioavailability
    • Dec
    • Kerbusch T, Wahlby U, Milligan PA, et al. Population pharmacokinetic modelling of darifenacin and its hydroxylated metabolite using pooled data, incorporating saturable first-pass metabolism, CYP2D6 genotype and formulation-dependent bioavailability. Br J Clin Pharmacol 2003 Dec; 56 (6): 639-52
    • (2003) Br J Clin Pharmacol , vol.56 , Issue.6 , pp. 639-652
    • Kerbusch, T.1    Wahlby, U.2    Milligan, P.A.3
  • 28
    • 0031985364 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of darifenacin in the mouse, rat, dog and man
    • Jan
    • Beaumont KC, Cussans NJ, Nichols DJ, et al. Pharmacokinetics and metabolism of darifenacin in the mouse, rat, dog and man. Xenobiotica 1998 Jan; 28 (1): 63-75
    • (1998) Xenobiotica , vol.28 , Issue.1 , pp. 63-75
    • Beaumont, K.C.1    Cussans, N.J.2    Nichols, D.J.3
  • 29
    • 0003979209 scopus 로고    scopus 로고
    • Novartis Pharma AG, Aug 26
    • Data on file. Novartis Pharma AG, 2004 Aug 26
    • (2004) Data on File
  • 30
    • 1242306671 scopus 로고    scopus 로고
    • Assessment of the relative in vivo potency of the hydroxylated metabolite of darifenacin in its ability to decrease salivary flow using pooled population pharmacokinetic-pharmacodynamic data
    • Feb
    • Kerbusch T, Milligan PA, Karlsson MO. Assessment of the relative in vivo potency of the hydroxylated metabolite of darifenacin in its ability to decrease salivary flow using pooled population pharmacokinetic-pharmacodynamic data. Br J Clin Pharmacol 2004 Feb; 57 (2): 170-80
    • (2004) Br J Clin Pharmacol , vol.57 , Issue.2 , pp. 170-180
    • Kerbusch, T.1    Milligan, P.A.2    Karlsson, M.O.3
  • 31
    • 1642276168 scopus 로고    scopus 로고
    • Darifenacin, an M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder
    • Apr; discussion 429
    • Haab F, Stewart L, Dwyer P. Darifenacin, an M3 selective receptor antagonist, is an effective and well-tolerated once-daily treatment for overactive bladder. Eur Urol 2004 Apr; 45 (4): 420-9; discussion 429
    • (2004) Eur Urol , vol.45 , Issue.4 , pp. 420-9
    • Haab, F.1    Stewart, L.2    Dwyer, P.3
  • 32
    • 2942695218 scopus 로고    scopus 로고
    • Darifenacin, an M3 selective receptor antagonist, reduces the frequency of nocturnal awakening, an important symptom of overactive bladder
    • Apr
    • Khullar V. Darifenacin, an M3 selective receptor antagonist, reduces the frequency of nocturnal awakening, an important symptom of overactive bladder [abstract no. 491]. J Urol 2004 Apr; 171 (4 Suppl.): 131
    • (2004) J Urol , vol.171 , Issue.4 SUPPL. , pp. 131
    • Khullar, V.1
  • 33
    • 8444251862 scopus 로고    scopus 로고
    • Efficacy, tolerability and safety of darifenacin given by a flexible titration dosing regimen
    • Aug 23-27; Paris [online]. Available from URL
    • Corcos J, Steers W. Efficacy, tolerability and safety of darifenacin given by a flexible titration dosing regimen [abstract no. 178]. Joint Meeting of the International Continence Society and the International Urogynecological Assocation; 2004 Aug 23-27; Paris [online]. Available from URL: http://www.icsoffice.org [Accessed 2004 Jul 2]
    • (2004) Joint Meeting of the International Continence Society and the International Urogynecological Assocation
    • Corcos, J.1    Steers, W.2
  • 34
    • 2942686519 scopus 로고    scopus 로고
    • Darifenacin prolongs median and minimum warning time associated with urinary urgency
    • Apr
    • Cardozo L, Dixon A. Darifenacin prolongs median and minimum warning time associated with urinary urgency [abstract]. Obstet Gynecol 2004 Apr; 103 (4 Suppl.): 130
    • (2004) Obstet Gynecol , vol.103 , Issue.4 SUPPL. , pp. 130
    • Cardozo, L.1    Dixon, A.2
  • 35
    • 33747887310 scopus 로고    scopus 로고
    • Efficacy and tolerability of darifenacin, a muscarinic M3 selective receptor antagonist, compared with oxybutynin in the treatment of patients with overactive bladder
    • Aug 23-27; Paris [online]. Available from URL
    • Zinner N, Tuttle J, Marks L. Efficacy and tolerability of darifenacin, a muscarinic M3 selective receptor antagonist, compared with oxybutynin in the treatment of patients with overactive bladder [abstract no. 378]. Joint Meeting of the International Continence Society and the International Urogynecological Assocation; 2004 Aug 23-27; Paris [online]. Available from URL: http://www.icsoffice.org [Accessed 2004 Jul 2]
    • (2004) Joint Meeting of the International Continence Society and the International Urogynecological Assocation
    • Zinner, N.1    Tuttle, J.2    Marks, L.3
  • 36
    • 2942636772 scopus 로고    scopus 로고
    • Darifenacin is well tolerated and provides significant improvement in the symptoms of overactive bladder: A pooled analysis of phase III studies
    • Apr
    • Chapple CR. Darifenacin is well tolerated and provides significant improvement in the symptoms of overactive bladder: a pooled analysis of phase III studies [abstract no. 487]. J Urol 2004 Apr; 171 (4 Suppl.): 130
    • (2004) J Urol , vol.171 , Issue.4 SUPPL. , pp. 130
    • Chapple, C.R.1
  • 38
    • 8444229043 scopus 로고    scopus 로고
    • Darifenacin, an M3 selective receptor antagonist, improves quality of life in patients with overactive bladder
    • Chapple C, Kelleher C, Perrault L. Darifenacin, an M3 selective receptor antagonist, improves quality of life in patients with overactive bladder [abstract no. 67]. Prog Urol 2004; 14 Suppl. 3: 22
    • (2004) Prog Urol , vol.14 , Issue.SUPPL. 3 , pp. 22
    • Chapple, C.1    Kelleher, C.2    Perrault, L.3
  • 39
    • 8444236441 scopus 로고    scopus 로고
    • Patient satisfaction, preference and willingness to reuse darifenacin in the treatment of overactive bladder
    • Oct 3-7; Honolulu [online]. Available from URL
    • Glavind K, Perrault L. Patient satisfaction, preference and willingness to reuse darifenacin in the treatment of overactive bladder [abstract no. UP-14.17]. 27th Congress of the Société International d'Urologie; 2004 Oct 3-7; Honolulu [online]. Available from URL: http://www.siu2004.com [Accessed 2004 Sep 30]
    • (2004) 27th Congress of the Société International d'Urologie
    • Glavind, K.1    Perrault, L.2
  • 40
    • 8444243446 scopus 로고    scopus 로고
    • 3SRA), is effective and well tolerated in elderly patients with overactive bladder
    • Apr
    • 3SRA), is effective and well tolerated in elderly patients with overactive bladder [abstract no. P321]. J Am Geriatr Soc 2004 Apr; 52 (4 Suppl.): 126-7
    • (2004) J Am Geriatr Soc , vol.52 , Issue.4 SUPPL. , pp. 126-127
    • Foote, J.E.1
  • 41
    • 8444232958 scopus 로고    scopus 로고
    • The effects of darifenacin on the reduction of incontinence episodes in patients with overactive bladder
    • Hill S. The effects of darifenacin on the reduction of incontinence episodes in patients with overactive bladder [abstract no. 610]. J Pelvic Med Surg 2004; 10 Suppl. 1
    • (2004) J Pelvic Med Surg , vol.10 , Issue.SUPPL. 1
    • Hill, S.1
  • 42
    • 8444220987 scopus 로고    scopus 로고
    • Central nervous system (CNS)-related adverse events in patients with overactive bladder (OAB) treated with darifenacin versus tolterodine
    • Oct 3-7; Honolulu [online]. Available from URL
    • Foote J, Glavind K, Kay G. Central nervous system (CNS)-related adverse events in patients with overactive bladder (OAB) treated with darifenacin versus tolterodine [abstract]. 27th Congress of the Société International d'Urologie; 2004 Oct 3-7; Honolulu [online]. Available from URL: http://www.siu2004.com [Accessed 2004 Sep 30]
    • (2004) 27th Congress of the Société International d'Urologie
    • Foote, J.1    Glavind, K.2    Kay, G.3
  • 43
    • 8444230223 scopus 로고    scopus 로고
    • Media release Oct 10 [online]. Available from URL
    • Novartis. Darifenacin increases warning time for OAB sufferers. Media release 2003 Oct 10 [online]. Available from URL: http://www.novartis.com [Accessed 2004 Jun 15]
    • (2003) Darifenacin Increases Warning Time for OAB Sufferers
  • 44
    • 8444247227 scopus 로고    scopus 로고
    • Media release Jul 30 [online]. Available from URL
    • Pharma Times. Novartis' Emselex wins nod for OAB. Media release 2004 Jul 30 [online]. Available from URL: http://www.pharmatimes.com/news/300704e.asp [Accessed 2004 Jul 30]
    • (2004) Novartis' Emselex Wins Nod for OAB


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