The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats

Journal of Anesthesia

Volumn 25, Issue 6, 2011, Pages 884-891

  Kim, Hyun Jung ^a   Seol, Tae Kyung ^b   Lee, Hee Jong ^b   Yaksh, Tony L ^c   Jun, Jong Hun ^b  

^a Jeju National University School of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c University of California   (United States)

Author keywords

Alpha 2 agonist; Delta agonist; Intrathecal injection; Kappa agonist; Mu agonist; Thermal hyperalgesia

Indexed keywords

2 (2,6 DIETHYLANILINO) 2 IMIDAZOLINE; 3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; DELTA OPIATE RECEPTOR AGONIST; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; KAPPA OPIATE RECEPTOR AGONIST; MORPHINE SULFATE; MU OPIATE RECEPTOR AGONIST; NALOXONE; NALTRINDOLE; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BURN; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; FOREFOOT; HOT PLATE TEST; HYPERALGESIA; MALE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; RAT; SKIN INJURY; SPINAL CORD; THERMAL INJURY; WITHDRAWAL REFLEX;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ANIMALS; BURNS; CLONIDINE; ENKEPHALIN, D-PENICILLAMINE (2,5)-; HYPERALGESIA; MALE; MORPHINE; PAIN THRESHOLD; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SPINAL CORD;

EID: 84355166643     PISSN: 09138668     EISSN: 14388359     Source Type: Journal    
DOI: 10.1007/s00540-011-1240-2     Document Type: Article

References (33)

1. RH LaMotte JG Thalhammer HE Torebjork CJ Robinson 1982 Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat J Neurosci 2 765 781 7086482 1:STN:280:DyaL383hsF2ksA%3D%3D (Pubitemid 12064611)
2. JD Hardy HG Wolff H Goodell 1950 Experimental evidence on the nature of cutaneous hyperalgesia J Clin Invest 29 115 140 15399521 10.1172/JCI102227 1:STN:280:DyaG3c%2FgvFWmsQ%3D%3D
3. M Sosnowski TL Yaksh 1990 Spinal administration of receptor-selective drugs as analgesics: new horizons J Pain Symptom Manag 5 204 213 10.1016/0885-3924(90)90010-H 1:STN:280:DyaK3czgvVemsA%3D%3D
4. MB Sabbe TL Yaksh 1990 Pharmacology of spinal opioids J Pain Symptom Manag 5 191 203 10.1016/0885-3924(90)90009-9 1:STN:280:DyaK3czgvVemsw%3D%3D
5. AB Malmberg TL Yaksh 1993 Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction Anesthesiology 79 270 281 8102041 10.1097/00000542-199308000-00012 1:CAS:528:DyaK3sXms1ahtLk%3D (Pubitemid 23224839)
6. S Saeki TL Yaksh 1992 Suppression by spinal alpha-2 agonists of motor and autonomic responses evoked by low- and high-intensity thermal stimuli J Pharmacol Exp Ther 260 795 802 1346645 1:CAS:528:DyaK38Xht1Sltbg%3D
7. C Schmauss TL Yaksh 1984 In vivo studies on spinal opiate receptor systems mediating antinociception. II. Pharmacological profiles suggesting a differential association of mu, delta and kappa receptors with visceral chemical and cutaneous thermal stimuli in the rat J Pharmacol Exp Ther 228 1 12 6319664 1:CAS:528:DyaL2cXps1GksQ%3D%3D (Pubitemid 14223374)
8. GE Leighton RE Rodriguez RG Hill J Hughes 1988 kappa-Opioid agonists produce antinociception after i.v. and i.c.v. but not intrathecal administration in the rat Br J Pharmacol 93 553 560 2836010 1:CAS:528:DyaL1cXhvVSjtLo%3D (Pubitemid 18073267)
9. KA Sluka JJ Rohlwing RA Bussey SA Eikenberry JM Wilken 2002 Chronic muscle pain induced by repeated acid injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists J Pharmacol Exp Ther 302 1146 1150 12183674 10.1124/jpet.102.033167 1:CAS:528:DC%2BD38XmsF2ht74%3D (Pubitemid 34920237)
10. K Hargreaves R Dubner F Brown C Flores J Joris 1988 A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia Pain 32 77 88 3340425 10.1016/0304-3959(88)90026-7 1:STN:280:DyaL1c7itlOntw%3D%3D
11. TL Yaksh TA Rudy 1976 Chronic catheterization of the spinal subarachnoid space Physiol Behav 17 1031 1036 14677603 10.1016/0031-9384(76)90029-9 1:STN:280:DC%2BD3srpsFynsA%3D%3D (Pubitemid 8063691)
12. PJ Tiseo TL Yaksh 1993 Dose-dependent antagonism of spinal opioid receptor agonists by naloxone and naltrindole: additional evidence for delta-opioid receptor subtypes in the rat Eur J Pharmacol 236 89 96 8391455 10.1016/0014-2999(93)90230-F 1:CAS:528:DyaK3sXks1aqsLo%3D (Pubitemid 23146854)
13. Y Takano TL Yaksh 1992 Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats J Pharmacol Exp Ther 261 764 772 1349648 1:CAS:528:DyaK38XktVSktbw%3D
14. Tallarida RJ, Murray RB. Manual of pharmacologic calculations with computer programs. 2nd ed. New York: Springer; 1986. p. 137-9.
15. FJ Stoddard RL Sheridan GN Saxe BS King BH King DS Chedekel JJ Schnitzer JA Martyn 2002 Treatment of pain in acutely burned children J Burn Care Rehabil 23 135 156 11882804 10.1097/00004630-200203000-00012 1:STN:280: DC%2BD387ltVajtg%3D%3D (Pubitemid 34242516)
16. S Moiniche JB Dahl H Kehlet 1993 Time course of primary and secondary hyperalgesia after heat injury to the skin Br J Anaesth 71 201 205 8123392 10.1093/bja/71.2.201 1:STN:280:DyaK2c7mvVyltg%3D%3D (Pubitemid 23229377)
17. JL Pedersen H Kehlet 1998 Secondary hyperalgesia to heat stimuli after burn injury in man Pain 76 377 384 9718256 10.1016/S0304-3959(98)00070-0 1:STN:280:DyaK1czot1ersA%3D%3D (Pubitemid 28342747)
18. N Nozaki-Taguchi TL Yaksh 1998 A novel model of primary and secondary hyperalgesia after mild thermal injury in the rat Neurosci Lett 254 25 28 9780083 10.1016/S0304-3940(98)00648-X 1:CAS:528:DyaK1cXmsFClsbo%3D (Pubitemid 28430616)
19. M Ueda M Hirose N Takei T Ibuki Y Naruse Y Ibata M Tanaka 2001 Foot hyperalgesia after thoracic burn injury-histochemical, behavioral and pharmacological studies Acta Histochem Cytochem 34 441 450 10.1267/ahc.34.441 1:CAS:528:DC%2BD38XivFGjsrg%3D (Pubitemid 34152384)
20. NE Atchison PF Osgood DB Carr SK Szyfelbein 1991 Pain during burn dressing change in children: relationship to burn area, depth and analgesic regimens Pain 47 41 45 1771092 10.1016/0304-3959(91)90009-M 1:STN:280: DyaK387itlKjuw%3D%3D
21. H Nagasaka TL Yaksh 1995 Effects of intrathecal mu, delta, and kappa agonists on thermally evoked cardiovascular and nociceptive reflexes in halothane-anesthetized rats Anesth Analg 80 437 443 7864404 1:CAS:528: DyaK2MXltlehsrs%3D
22. TL Yaksh 1997 Pharmacology and mechanisms of opioid analgesic activity Acta Anaesthesiol Scand 41 94 111 9061092 10.1111/j.1399-6576.1997.tb04623.x 1:CAS:528:DyaK2sXhs1Omsrg%3D (Pubitemid 27072912)
23. H Nagasaka H Awad TL Yaksh 1996 Peripheral and spinal actions of opioids in the blockade of the autonomic response evoked by compression of the inflamed knee joint Anesthesiology 85 808 816 8873551 10.1097/00000542-199610000-00016 1:CAS:528:DyaK28XmsFCnurg%3D (Pubitemid 26346720)
24. W Rahman MR Dashwood M Fitzgerald A Aynsley-Green AH Dickenson 1998 Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia Brain Res Dev Brain Res 108 239 254 9693800 10.1016/S0165-3806(98)00054-6 1:CAS:528:DyaK1cXjs1ags7Y%3D (Pubitemid 28332835)
25. JC Eisenach CY Tong 1991 Site of hemodynamic effects of intrathecal alpha 2-adrenergic agonists Anesthesiology 74 766 771 1672580 10.1097/00000542- 199104000-00021 1:CAS:528:DyaK3MXisVSntrc%3D
26. JR Howe JY Wang TL Yaksh 1983 Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine J Pharmacol Exp Ther 224 552 558 6131120 1:CAS:528:DyaL3sXhslejt70%3D (Pubitemid 13152685)
27. EA Kalso R Poyhia PH Rosenberg 1991 Spinal antinociception by dexmedetomidine, a highly selective alpha 2-adrenergic agonist Pharmacol Toxicol 68 140 143 1677190 10.1111/j.1600-0773.1991.tb02052.x 1:CAS:528: DyaK3MXhsFOisb4%3D
28. MS Monasky AR Zinsmeister CW Stevens TL Yaksh 1990 Interaction of intrathecal morphine and ST-91 on antinociception in the rat: dose-response analysis, antagonism and clearance J Pharmacol Exp Ther 254 383 392 1974633 1:CAS:528:DyaK3cXlsVGhtb0%3D (Pubitemid 20262070)
29. SV Reddy JL Maderdrut TL Yaksh 1980 Spinal cord pharmacology of adrenergic agonist-mediated antinociception J Pharmacol Exp Ther 213 525 533 6110767 1:CAS:528:DyaL3cXks1Wgsbw%3D (Pubitemid 10085156)
30. K Murata I Nakagawa Y Kumeta LM Kitahata JG Collins 1989 Intrathecal clonidine suppresses noxiously evoked activity of spinal wide dynamic range neurons in cats Anesth Analg 69 185 191 2548415 10.1213/00000539-198908000-00008 1:CAS:528:DyaK3MXhsFOjsr0%3D (Pubitemid 20045048)
31. JC Doxey CF Smith JM Walker 1977 Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors Br J Pharmacol 60 91 96 18248 1:CAS:528:DyaE2sXlsVGmtLY%3D (Pubitemid 8087297)
32. TN Lavin BB Hoffman RJ Lefkowitz 1981 Determination of subtype selectivity of alpha-adrenergic antagonists: comparison of selective and nonselective radioligands Mol Pharmacol 20 28 34 6117003 1:CAS:528: DyaL3MXltVyhu7w%3D (Pubitemid 11042410)
33. K Starke E Borowski T Endo 1975 Preferential blockade of presynaptic alpha-adrenoceptors by yohimbine Eur J Pharmacol 34 385 388 186273 10.1016/0014-2999(75)90268-X 1:CAS:528:DyaE28XosVSksQ%3D%3D