Pseudomonas aeruginosa potentiates the lethal effect of intestinal ischemia-reperfusion injury: The role of in vivo virulence activation

Journal of Trauma - Injury, Infection and Critical Care

Volumn 71, Issue 6, 2011, Pages 1575-1582

  Fink, David ^a,b,c   Romanowski, Kathleen ^a   Valuckaite, Vesta ^a,b   Babrowski, Trissa ^a   Kim, Moses ^a,d   Matthews, Jeffrey B ^a,b   Liu, Donald ^a   Zaborina, Olga ^a   Alverdy, John C ^a,b  

^a UNIVERSITY OF CHICAGO   (United States)

^b HARVARD UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Intestinal ischemia reperfusion; Pseudomonas aeruginosa; Small bowel bacterial overgrowth; Virulence activation; Virulence transcription regulation

Indexed keywords

LECTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BIOLUMINESCENCE; CONTROLLED STUDY; ILEUM; IN VIVO STUDY; INOCULATION; INTESTINE ISCHEMIA; KIDNEY; LETHALITY; LIVER; LUNG; MESENTERY LYMPH NODE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; REPERFUSION INJURY; SHAM PROCEDURE; SPLEEN; SUPERIOR MESENTERIC ARTERY OBSTRUCTION;

ANIMALS; BACTERIAL ADHESION; BACTERIAL TRANSLOCATION; CHI-SQUARE DISTRIBUTION; DISEASE MODELS, ANIMAL; INTESTINE, SMALL; KAPLAN-MEIER ESTIMATE; MICE; MICE, INBRED C57BL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RANDOM ALLOCATION; REFERENCE VALUES; REPERFUSION INJURY; SEPSIS; SURVIVAL ANALYSIS; VIRULENCE;

EID: 84355161669     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31821cb7e5     Document Type: Article

References (23)

1. Kola A, Schwab F, Bärwolff S, et al. Is there an association between nosocomial infection rates and bacterial cross transmissions? Crit Care Med. 2010;38:46-50.
2. Casadevall A, Pirofski LA. Accidental virulence, cryptic pathogenesis, martians, lost hosts, and the pathogenicity of environmental microbes. Eukaryot Cell. 2007;6:2169-2174.
3. Tamme K, Liigant A, Tapfer H, Talvik R. Bacterial dissemination and the value of blood cultures in patients who die of septic shock. J Int Med Res. 2000;28:199-206.
4. Marshall JC, Christou NV, Meakins JL. The gastrointestinal tract. The "undrained abscess" of multiple organ failure. Ann Surg. 1993;218:111-118.
5. Shimizu K, Ogura H, Goto M, et al. Altered gut flora and environment in patients with severe SIRS. J Trauma. 2006;60:126-133.
6. Gomez R, Murray CK, Hospenthal DR, et al. Causes of mortality by autopsy findings of combat casualties and civilian patients admitted to a burn unit. J Am Coll Surg. 2009;208:348-354.
7. Sharma BR, Harish D, Singh VP, Bangar S. Septicemia as a cause of death in burns: an autopsy study. Burns. 2006;32:545-549.
8. Murono K, Hirano Y, Koyano S, Ito K, Fujieda K. Molecular comparison of bacterial isolates from blood with strains colonizing pharynx and intestine in immunocompromised patients with sepsis. J Med Microbiol. 2003;52(Pt 6):527-530. (Pubitemid 36774242)
9. Mencacci A, Cenci E, Repetto A, et al. A multidrug-resistant Pseudomonas aeruginosa isolate from a lethal case of sepsis induces necrosis of human neutrophils. J Infect. 2006;53:e259-e264. (Pubitemid 44688991)
10. Alverdy JC, Chang EB. The re-emerging role of the intestinal microflora in critical illness and inflammation: why the gut hypothesis of sepsis syndrome will not go away. J Leukoc Biol. 2008;83:461-466. (Pubitemid 351966851)
11. Zaborina O, Lepine F, Xiao G, et al. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. PLoS Pathog. 2007;3:e35.
12. Patel NJ, Zaborina O, Wu L, et al. Recognition of intestinal epithelial HIF-1alpha activation by Pseudomonas aeruginosa. Am J Physiol Gastrointest Liver Physiol. 2007;292:G134-G142. (Pubitemid 46090258)
13. Winzer K, Falconer C, Garber NC, Diggle SP, Camara M, Williams P. The Pseudomonas aeruginosa lectins PA-IL and PA-IIL are controlled by quorum sensing and by RpoS. J Bacteriol. 2000;182: 6401-6411.
14. Wiles S, Pickard KM, Peng K, MacDonald TT, Frankel G. In vivo bioluminescence imaging of the murine pathogen Citrobacter rodentium. Infect Immun. 2006;74:5391-5396. (Pubitemid 44300459)
15. Wu L, Holbrook C, Zaborina O, et al. Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-IL lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System. Ann Surg. 2003; 238:754-764. (Pubitemid 38182269)
16. Alverdy J, Holbrook C, Rocha F, et al. Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann Surg. 2000;232:480-489.
17. Yale CE, Balish E. Intestinal strangulation in germfree and monocontaminated dogs. Arch Surg. 1979;114:445-448. (Pubitemid 9165161)
18. Seal JB, Morowitz M, Zaborina O, An G, Alverdy JC. The molecular Koch's postulates and surgical infection: a view forward. Surgery. 2010;147:757-765.
19. Laughlin RS, Musch MW, Hollbrook CJ, Rocha FM, Chang EB, Alverdy JC. The key role of Pseudomonas aeruginosa PA-IL lectin on experimental gut-derived sepsis. Ann Surg. 2000;232:133-142. (Pubitemid 30456561)
20. Tancrède CH, Andremont AO. Bacterial translocation and gram-negative bacteremia in patients with hematological malignancies. J Infect Dis. 1985; 152:99-103. (Pubitemid 15038840)
21. Chemani C, Imberty A, de Bentzmann S, et al. Role of LecA and LecB lectins in Pseudomonas aeruginosa-induced lung injury and effect of carbohydrate ligands. Infect Immun. 2009;77:2065-2075.
22. Kim HJ, Boedicker JQ, Choi JW, Ismagilov RF. Defined spatial structure stabilizes a synthetic multispecies bacterial community. Proc Natl Acad Sci U S A. 2008;105:18188-18193.
23. Ye X, Ding J, Zhou X, Chen G, Liu SF. Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis. J Exp Med. 2008;205:1303-1315. (Pubitemid 351831488)