The influence of residual neuromuscular block on the incidence of critical respiratory events. A randomised, prospective, placebo-controlled trial

European Journal of Anaesthesiology

Volumn 28, Issue 12, 2011, Pages 842-848

  Sauer, Martin ^a   Stahn, Alexander ^a   Soltesz, Stefan ^b   Noeldge Schomburg, Gabriele ^a   Mencke, Thomas ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

^b Hospital of Leverkusen   (Germany)

Author keywords

Neostigmine; Neuromuscular blockade; Post operative pulmonary complications; Post operative residual curarisation; Rocuronium

Indexed keywords

ATROPINE; NEOSTIGMINE; PLACEBO; PROPOFOL; REMIFENTANIL; ROCURONIUM; SEVOFLURANE; SUFENTANIL;

ADULT; AGED; ANESTHETIC RECOVERY; ARTICLE; CONTROLLED STUDY; DOUBLE BURST STIMULATION; DRUG ANTAGONISM; ENDOTRACHEAL TUBE; GENERAL ANESTHESIA; HUMAN; HYPOXEMIA; MAJOR CLINICAL STUDY; MUSCLE WEAKNESS; NERVE PARALYSIS; ORTHOPEDIC SURGERY; PARALYSIS; RANDOMIZED CONTROLLED TRIAL; RESIDUAL NEUROMUSCULAR BLOCK; STATISTICAL ANALYSIS; STIMULATION; TRAIN OF FOUR RATIO;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANOXIA; CRITICAL ILLNESS; FEMALE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NEUROMUSCULAR BLOCKADE; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84255185340     PISSN: 02650215     EISSN: 13652346     Source Type: Journal    
DOI: 10.1097/EJA.0b013e328345cd11     Document Type: Article

References (18)

1. Arbous MS, Meursing AE, van Kleef JW, et al. Impact of anesthesia management characteristics on severe morbidity and mortality. Anesthesiology 2005;102:257-268. (Pubitemid 40189072)
2. Debaene B, Plaud B, Dilly MP, Donati F. Residual paralysis in the PACU after a single intubating dose of nondepolarizing muscle relaxant with an intermediate duration of action. Anesthesiology 2003;98:1042-1048. (Pubitemid 36520189)
3. Pedersen T, Viby-Mogensen J, Ringsted C. Anaesthetic practice and postoperative pulmonary complications. Acta Anaesthesiol Scand 1992;36:812-818.
4. Rose DK, Cohen MM, Wigglesworth DF, et al. Critical respiratory events in the postanesthesia care unit: patient, surgical, and anesthetic factors. Anesthesiology 1994;81:410-418. (Pubitemid 24320633)
5. Berg H, Viby-Mogensen J, Roed J, et al. Residual neuromuscular block is a risk factor for postoperative pulmonary complications: a prospective, randomized, and blinded study of postoperative pulmonary complications after atracurium, vecuronium, and pancuronium. Acta Anaesthesiol Scand 1997;41:1095-1103.
6. Murphy GS, Szokol JW, Marymont JH, et al. Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit. Anesth Analg 2008;107:130-137.
7. Lien CA. Neostigmine: how much is necessary for patients who receive a nondepolarizing neuromuscular blocking agent? Anesthesiology 2010;112:16-18.
8. Urbaniak GC, Plous S. Research randomizier; (1997, 2007). http:/www.randomizer.org.
9. Capron F, Alla F, Hottier C, et al. Can acceleromyography detect low levels of residual paralysis? A probability approach to detect a mechanomyographic train-of-four ratio of 0.9. Anesthesiology 2004;100:1119-1124. (Pubitemid 38541966)
10. Fuchs-Buder T, Claudius C, Skovgaard LT, et al. Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision. Acta Anaesthesiol Scand 2007;51:789-808. (Pubitemid 47063004)
11. Schreiber JU, Mucha E, Fuchs-Buder T. Residual paralysis following a single dose of atracurium: results from a quality assurance trial. Eur J Anaesthesiol 2010;27:993-994.
12. Mencke T, Soltesz S, Sauer M, et al. Are women more sensitive to a precurarization dose of rocuronium than men? Acta Anaesthesiol Scand 2008;52:1051-1055.
13. Mencke T, Schreiber JU, Becker C, et al. Pretreatment before succinylcholine for outpatient anesthesia? Anesth Analg 2002;94:573-576. (Pubitemid 34177552)
14. Murphy GS, Szokol JW, Marymont JH, et al. Intraoperative acceleromyographic monitoring reduces the risk of residual neuromuscular blockade and adverse respiratory events in the postanesthesia care unit. Anesthesiology 2008;109:389-398.
15. Bissinger U, Schimek F, Lenz G. Postoperative residual paralysis and respiratory status: a comparative study of pancuronium and vecuronium. Physiol Res 2000;49:455-462.
16. Mitchell C, Smoger S, Pfeifer M, et al. Multivariate analysis of factors associated with postoperative pulmonary complications following general elective surgery. Arch Surg 1998;133:194-198. (Pubitemid 28092921)
17. Kroenke K, Lawrence VA, Theroux JF, et al. Postoperative complications after thoracic and major abdominal surgery in patients with and without obstructive lung disease. Chest 1993;104:1445-1451. (Pubitemid 23327861)
18. Fuchs-Buder T, Meistelman C, Alla F, et al. Antagonism of low degrees of atracurium-induced neuromuscular blockade: dose-effect relationship for neostigmine. Anesthesiology 2010;112:34-40.