Adalimumab for the treatment of refractory sciatica induced by disc prolapse: Abu Dhabi experience

Qatar Medical Journal

Volumn 20, Issue 1, 2011, Pages 41-44

  Al Izzi, Mustafa ^a   Hussein, I ^b   Mahmoud, N ^b  

^a ZAYED MILITARY HOSPITAL   (United Arab Emirates)

^b MAFRAQ HOSPITAL   (United Arab Emirates)

Author keywords

Adalimumab; Anti TNF; Sciatica

Indexed keywords

ADALIMUMAB;

ADULT; ARTICLE; BACKACHE; CLINICAL ARTICLE; FEMALE; HUMAN; INTERVERTEBRAL DISK HERNIA; ISCHIALGIA; LEG PAIN; MALE; VISUAL ANALOG SCALE;

EID: 84255176497     PISSN: 02538253     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic Cytokine expression in degenerated and herniated human intervertebral discs: IL-1 beta and TNF-alpha expression profile. Arthritis Res Ther 2007; 9(4): R77
2. Podichetty VK. The aging spine: The role of inflammatory mediators in intervertebral disc degeneration. Cell Mol Biol 2007; 53(5): 4-18. (Pubitemid 350164301)
3. Igarashi T, Kikuchi S, Shubayev V. Exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology: molecular, histologic, and behavioral comparisons in rats. Spine 2000; 25: 2975-80.
4. Modic MT, Ross JS. Lumbar degenerative disc disease. Radiology 2007; 245(1): 43-61.
5. Taylor PC, Williams RO, Feldmann F. Tumor necrosis factor as a therapeutic target for immune mediated inflammatory diseases. Curr Op Biotech 2004; 15(6): 557-583.
6. Mixter W. Rupture of the intervertebral disc with involvement of the spinal canal. NEJM 1934; 211: 210-115.
7. Peng B, et al. Chemical radiculitis. Pain 2007; 127(1-2): 11-16. (Pubitemid 44959427)
8. Aoki Y, Rydevik B, Kikuchi S. Local application of disc-related cytokines on spinal nerve roots. Spine 2002; 27: 1614-1617. (Pubitemid 34839642)
9. Onda A, Yabuki S, Kikuchi S. Effects of neutralizing antibodies to tumor necrosis factor-alpha on nucleus pulposus-induced abnormal nociresponses in rat dorsal horn neurons. Spine 2003; 28: 967-972. (Pubitemid 36583324)
10. Seguin CA, Pilliar RM, Roughley PJ. Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue. Spine 2005; 30(17): 1940-1948. (Pubitemid 41292217)
11. Mulleman D. Pathophysiology of disc related low back pain and sciatica. Evidence supporting treatment with TNF-alpha antagonists. Joint Bone Spine 2006; 73(3): 270-277.
12. Goupille P, Mulleman D, Valat JP. Radiculopathy associated with disc herniation. Ann Rheum Dis 2006; 65: 141-143. (Pubitemid 43131984)
13. Korhonen T, Karppinen J, Malmivaara A. Efficacy of infliximab for disc hemiation-induced sciatica: One-year follow-up. Spine 2004; 29: 2115-2119. (Pubitemid 40353199)
14. Korhonen T, Karppinen J, Paimela L. The treatment of disc hemiation-induced sciatica with infliximab: results of a randomized, controlled, 3-month follow-up study. Spine 2005; 30: 2742-2748.
15. Brennan S, Vanharanta H, Keenan A, et al. Treating sciatica with adalimumab: a pilot study. EULAR 2004; Berlin, Germany. Abstract SAT 0146.
16. Genevay S, Stingelin S, Gabay C. Efficacy of etanercept in the treatment of acute and severe sciatica: a pilot study. Ann Rheum Dis 2004; 63: 1120-1123. (Pubitemid 39120364)