Ionic mechanisms of desflurane on prolongation of action potential duration in rat ventricular myocytes

Yonsei Medical Journal

Volumn 53, Issue 1, 2012, Pages 204-212

  Chae, Jee Eun ^a   Kim, Hyun Soo ^b   Ahn, Duck Sun ^a   Park, Wyun Kon ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

Action potential; Cardiac myocytes; Desflurane; Rat; Transient outward K+ current

Indexed keywords

CALCIUM CHANNEL L TYPE; DESFLURANE; POTASSIUM ION;

AMPLITUDE MODULATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HYPERPOLARIZATION; IONIC MECHANISM; MEMBRANE STEADY POTENTIAL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; QT PROLONGATION; RAT; ROOM TEMPERATURE; STEADY STATE; VOLTAGE CLAMP;

ACTION POTENTIALS; ANESTHETICS, INHALATION; ANIMALS; CALCIUM CHANNELS, L-TYPE; HEART CONDUCTION SYSTEM; HEART VENTRICLES; ISOFLURANE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84255169386     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2012.53.1.204     Document Type: Article

References (31)

1. Yildirim H, Adanir T, Atay A, Katircioǧlu K, Savaci S. The effects of sevoflurane, isoflurane and desflurane on QT interval of the ECG. Eur J Anaesthesiol 2004;21:566-70.
2. Silay E, Kati I, Tekin M, Guler N, Huseyinoglu UA, Coskuner I, et al. Comparison of the effects of desflurane and sevoflurane on the QTc interval and QT dispersion. Acta Cardiol 2005;60:459-64.
3. Owczuk R, Wujtewicz MA, Sawicka W, Lasek J, Wujtewicz M. The Influence of desflurane on QTc interval. Anesth Analg 2005;101:419-22.
4. Aypar E, Karagoz AH, Ozer S, Celiker A, Ocal T. The effects of sevoflurane and desflurane anesthesia on QTc interval and cardiac rhythm in children. Paediatr Anaesth 2007;17:563-7.
5. Park WK, Kim MH, Ahn DS, Chae JE, Jee YS, Chung N, et al. Myocardial depressant effects of desflurane: mechanical and electrophysiologic actions in vitro. Anesthesiology 2007;106:956-66.
6. Carmeliet E. Mechanisms and control of repolarization. Eur Heart J 1993;14 Suppl H:3-13.
7. Coraboeuf E. Ionic basis of electrical activity in cardiac tissues. Am J Physiol 1978;234:H101-16.
8. Rees S, Curtis MJ. Which cardiac potassium channel subtype is the preferable target for suppression of ventricular arrhythmias? Pharmacol Ther 1996;69:199-217.
9. Wettwer E, Amos G, Gath J, Zerkowski HR, Reidemeister JC, Ravens U. Transient outward current in human and rat ventricular myocytes. Cardiovasc Res 1993;27:1662-9.
10. Näbauer M, Beuckelmann DJ, Erdmann E. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ Res 1993;73:386-94.
11. Nánási PP, Varró A, Lathrop DA. Ionic currents in ventricular myocytes isolated from the heart of a patient with idiopathic cardiomyopathy. Cardioscience 1992;3:85-9.
12. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981;391:85-100.
13. + current but not the inward rectifier in rat ventricular myocytes. J Pharmacol Exp Ther 1990;255:1038-46.
14. + channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes. J Pharmacol Exp Ther 1994;269: 66-74.
15. + currents in rat ventricular myocytes. Am J Physiol 2003;285:H661-8.
16. Apkon M, Nerbonne JM. Characterization of two distinct depolarization-activated K+ currents in isolated adult rat ventricular myocytes. J Gen Physiol 1991;97:973-1011.
17. Hönemann CW, Washington J, Hönemann MC, Nietgen GW, Durieux ME. Partition coefficients of volatile anesthetics in aqueous electrolyte solutions at various temperatures. Anesthesiology 1998;89:1032-5.
18. Hume JR, Giles W. Ionic currents in single isolated bullfrog atrial cells. J Gen Physiol 1983;81:153-94.
19. Hume JR, Uehara A. Ionic basis of the different action potential configurations of single guinea-pig atrial and ventricular myocytes. J Physiol 1985;368:525-44.
20. Josephson IR, Sanchez-Chapula J, Brown AM. Early outward current in rat single ventricular cells. Circ Res 1984;54:157-62.
21. Litovsky SH, Antzelevitch C. Transient outward current prominent in canine ventricular epicardium but not endocardium. Circ Res 1988;62:116-26.
22. Giles W, Shimoni Y. Comparison of sodium-calcium exchanger and transient inward currents in single cells from rabbit ventricle. J Physiol 1989;417:465-81.
23. Coraboeuf E, Carmeliet E. Existence of two transient outward currents in sheep cardiac Purkinje fibers. Pflugers Arch 1982;392: 352-9.
24. Escande D, Coulombe A, Faivre JF, Deroubaix E, Coraboeuf E. Two types of transient outward currents in adult human atrial cells. Am J Physiol 1987;252:H142-8.
25. + dependence. J Physiol 1991;435:395-420.
26. + currents in mammalian cardiac and glial cells. J Pharmacol Exp Ther 1990;254:560-9.
27. Walker MJ, Beatch GN. Electrically induced arrhythmias in the rat. Proc West Pharmacol Soc 1988;31:167-70.
28. Nichols CG, Makhina EN, Pearson WL, Sha Q, Lopatin AN. Inward rectification and implications for cardiac excitability. Circ Res 1996;78:1-7.
29. The Sicilian gambit. A new approach to the classification of antiarrhythmic drugs based on their actions on arrhythmogenic mechanisms. Task Force of the Working Group on Arrhythmias of the European Society of Cardiology. Circulation 1991;84:1831-51.
30. Gueugniaud PY, Hanouz JL, Vivien B, Lecarpentier Y, Coriat P, Riou B. Effects of desflurane in rat myocardium: comparison with isoflurane and halothane. Anesthesiology 1997;87:599-609.
31. Chae JE, Ahn DS, Kim MH, Lynch C 3rd, Park WK. Electrophysiologic mechanism underlying action potential prolongation by sevoflurane in rat ventricular myocytes. Anesthesiology 2007; 107:67-74.