Histone H3 covalent modifications driving response of BCR-ABL1+ cells sensitive and resistant to imatinib to Aurora kinase inhibitor MK-0457

British Journal of Haematology

Volumn 156, Issue 2, 2012, Pages 265-268

  Mancini, Manuela ^a   Aluigi, Michela ^a   Leo, Elisa ^a   Marcozzi, Chiara ^a   Castagnetti, Fausto ^a   Barbieri, Enza ^a   Santucci, Maria Alessandra ^a  

^a Dipartimento di Scienze Radiologiche e Istopatologiche 'Luigi Galvani'   (Italy)

Author keywords

Aurora kinase inhibitors; BCR ABL1; Chromatin covalent modifications; Chronic myeloid leukaemia; Imatinib mesylate

Indexed keywords

BCR ABL PROTEIN; BCR ABL1 PROTEIN; HETEROCHROMATIN PROTEIN 1; HISTONE H3; IMATINIB; TOZASERTIB; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; CANCER RESISTANCE; CELL CYCLE ARREST; CONTROLLED STUDY; ENZYME INHIBITION; GENE SILENCING; HISTONE MODIFICATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LETTER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; TRANSCRIPTION REGULATION;

ANIMALS; DRUG RESISTANCE, NEOPLASM; HISTONES; HUMANS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MICE; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES;

EID: 84155186350     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08830.x     Document Type: Letter

References (10)

1. Brusa, G., Zuffa, E., Mancini, M., Benvenuti, M., Calonghi, N., Barbieri, E. & Santucci, M.A. (2006) P210 BCR-ABL tyrosine kinase interaction with histone deacetylase (Hdac) 1 modifies histone H4 acetylation and chromatin structure of chronic myeloid leukaemia hematopoietic progenitors. British Journal of Haematology, 132, 359-369.
2. Corrado, P., Mancini, M., Brusa, G., Petta, S., Martinelli, G., Barbieri, E. & Santucci, M.A. (2008) Acetylation of FOXO3a transcription factor in response to imatinib of chronic myeloid leukemia. Leukemia, 23, 405-405.
3. Crosio, C., Fimia, G.M., Loury, R., Kimura, M., Okano, Y., Zhou, H., Sen, S., Allis, C.D. & Sassone-Corsi, P. (2002) Mitotic phosphorylation of histone H3: Spatio-temporal regulation by mammalian Aurora kinases. Molecular and Cellular Biology, 22, 874-885.
4. bcr/abl protein. Proceedings of the National Academy of Sciences the United States of America, 85, 9312-9316.
5. Donato, N.J., Fang, D., Sun, H., Giannola, D., Peterson, L.F. & Talpaz, M. (2010) Targets and effectors of the cellular response to aurora kinase inhibitor MK-1457 (VX-680) in imatinib sensitive and resistant chronic myelogenous leukemia. Biochemical Pharmacology, 79, 688-697.
6. Fischle, W., Tseng, B.S., Dormann, H.L., Ueberheide, B.M., Garcia, B.A., Shabanowitz, J., Hunt, D.F., Funabiki, H. & Allis, C.D. (2005) Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature, 438, 1116-1122.
7. + cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. Leukemia Research, 32, 1857-1865.
8. Stewart, M.D., Li, J. & Wong, J. (2005) Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Molecular and Cellular Biology, 25, 2525-2538.
9. Young, M.S., Shah, N.P., Chao, L.H., Seeliger, M., Milanov, Z.V., Biggs, III, W.H., Treiber, D.K., Patel, H.K., Zarrinkar, P.P., Lockhart, D.J., Sawyers, C.L. & Kuriyan, J. (2006) Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680. Cancer Research, 66, 1007-1014.
10. Zippo, A., Serafini, R., Rocchigiani, M., Pennacchini, S., Krepelova, A. & Oliviero, S. (2009) Histone crosstalk between H3S10ph and H4K16ac generates a histone code that mediates transcription elongation. Cell, 138, 1122-1136.