Management of patients receiving oral anticoagulants using computer dosing software - does everyone agree? Data from a UK NEQAS (blood coagulation) exercise

International Journal of Laboratory Hematology

Volumn 34, Issue 1, 2012, Pages 70-80

  Jennings, I ^a   Walker, I D ^a   Kitchen, S ^a   Kitchen, D ^a   Woods, T A L ^a   Keeling, D ^b   Warner, B ^c   Cotton, P ^d   Maclean, R ^e  

^a UK NEQAS Blood Coagulation   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

^c NATIONAL PATIENT SAFETY AGENCY   (United Kingdom)

^d KING S MILL HOSPITAL   (United Kingdom)

^e ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

Anticoagulation; Computerized dosing support systems; Proficiency testing

Indexed keywords

ANTICOAGULANT AGENT; ERYTHROMYCIN; WARFARIN;

ARTICLE; COMPUTER PROGRAM; HEALTH PROGRAM; HUMAN; POINT OF CARE TESTING; PRIORITY JOURNAL; UNITED KINGDOM;

ADMINISTRATION, ORAL; ADULT; AGED; ANTICOAGULANTS; BLOOD COAGULATION DISORDERS; FEMALE; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MEDICATION SYSTEMS; MIDDLE AGED; QUESTIONNAIRES; SOFTWARE; WARFARIN;

EID: 84155181102     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2011.01359.x     Document Type: Article

References (12)

1. Baglin T.P., Keeling D.M. & Watson H.G.; British Committee for Standards in Haematology (2006) Guidelines on oral anticoagulation (warfarin): third edition-2005 update. British Journal Haematology 132, 277-285.
2. van den Besselaar A.M. (1993) International standardization of laboratory control of oral anticoagulation therapy: a survey of thromboplastin reagents used for prothrombin time testing. Journal of Heart Valve Disease 2, 42-52.
3. Fitzmaurice D.A., Hobbs F.D., Murray E.T., Bradley C.P. & Holder R. (1996) Evaluation of computerized decision support for oral anticoagulation management based in primary care. British Journal of General Practice 46, 533-555.
4. Jennings I., Kitchen D.P., Kitchen S., Woods T.A.L. & Walker I.D. (2007) Variability in anticoagulant dosing recommendations; results from two UK NEQAS for blood coagulation exercises. Journal of Thrombosis and Haemostasis 5(Suppl. 2), P-M-553.
5. Jowett S., Bryan S., Poller L., van den Besselaar A.M., van der Meer F.J., Palareti G., Shiach C., Tripodi A., Keown M., Ibrahim S., Lowe G., Moia M., Turpie A.G. & Jespersen J. (2009) The cost-effectiveness of computer-assisted anticoagulant dosage: results from the European Action on Anticoagulation (EAA) multicentre study. Journal of Thrombosis and Haemostasis 7, 1482-1490.
6. van Leeuwen Y., Rombouts E.K., Kruithof C.J., van der Meer F.J. & Rosendaal F.R. (2007) Improved control of oral anticoagulant dosing: a randomized controlled trial comparing two computer algorithms. Journal of Thrombosis and Haemostasis 5, 1644-1649.
7. Manotti C., Moia M., Palareti G., Pengo V., Ria L. & Dettori A.G. (2001) Effect of computer-aided management on the quality of treatment in anticoagulated patients: a prospective, randomized, multicenter trial of APROAT (Automated PRogram for Oral Anticoagulant Treatment). Haematologica 86, 1060-1070.
8. NHS National Patient Safety Agency (2007) Patient Safety Alert 18, 28th March 2007. Available at: (accessed 28 January 2011).
9. Oppenkowski T.P., Murray E.T., Sandhar H. & Fitzmaurice D.A. (2003) External quality assessment for wardarin dosing using computerised decision support software. Journal of Clinical Pathology 56, 605-607.
10. Poller L., Keown M., Ibrahim S., Lowe G., Moia M., Turple A.G., Roberts C., van den Besselaar A.M., van der Meer F.J., Tripodi A., Palareti G., Shiach C., Bryan S., Samama M., Burgess-Wilson M., Heagerty A., Maccallum P., Wright D. & Jespersen J. (2008) An international multicenter randomized study of computer-assisted oral anticoagulant dosage vs. medical staff dosage. Journal of Thrombosis and Haemostasis 6, 935-943.
11. Poller L., Roberts C., Ibrahim S., Keown M., Ageno W., van den Besselaar A.M.H.P., Fitzmaurice D., Harenberg J., Kitchen S., Lowe G., Moia M., Palareti G., Tripodi A., Turpie A.G.G. & Jespersen J.; on behalf of the subcommittee on control of anticoagulation of the SSC of the ISTH (2009) Screening computer-assisted dosage programs for anticoagulation with warfarin and other vitamin K antagonists: minimum safety requirements for individual programs. Journal of Thrombosis and Haemostasis 7, 1736.
12. Preston F.E. (1995) Quality control and oral anticoagulation. Thrombosis and Haemostasis 74, 515-520.