Large-scale randomized clinical study on functional dyspepsia treatment with mosapride or teprenone: Japan Mosapride Mega-Study (JMMS)

Journal of Gastroenterology and Hepatology (Australia)

Volumn 27, Issue 1, 2012, Pages 62-68

  Hongo, Michio ^a   Harasawa, Shigeru ^c   Mine, Tetsuya ^d   Sasaki, Iwao ^b   Matsueda, Kei ^e   Kusano, Motoyasu ^h   Hanyu, Nobuyoshi ^f   Nakada, Koji ^g   Shibata, Chikashi ^b  

^a TOHOKU UNIVERSITY HOSPITAL   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Saiseikai Kawaguchi Hospital   (Japan)

^d TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e Sakura Life Clinic   (Japan)

^f Machida Municipal Hospital   (Japan)

^g JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Epigastric pain; Functional dyspepsia; Gastric stasis; Mosapride; Teprenone

Indexed keywords

MOSAPRIDE; TEPRENONE;

ADULT; ARTICLE; CLINICAL EFFECTIVENESS; CLINICAL STUDY; COMPARATIVE STUDY; CONSTIPATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DYSPEPSIA; ENDOSCOPE; EPIGASTRIC PAIN; FATIGUE; FEMALE; GASTRIC STASIS; GASTROINTESTINAL SYMPTOM; HUMAN; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; TREATMENT DURATION;

EID: 84155178376     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2011.06949.x     Document Type: Article

References (25)

1. Tack J, Talley NJ, Camilleri M etal. Functional gastroduodenal disorders. Gastroenterology 2006; 130: 1466-9.
2. Talley NJ, Silverstein MD, Agreus L, Nyren O, Sonnenberg A, Holtmann G. AGA technical review: evaluation of dyspepsia. American Gastroenterological Association. Gastroenterology 1998; 114: 582-95.
3. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut 1999; 45 (Suppl. 2): II37-42.
4. Hongo M, Nomura T. [Functional dyspepsia.] Jap. Med. Assoc. J. 2001; 126: 368-71. (in Japanese).
5. Hongo M. [Diagnosis of functional dyspepsia (NUD).] Jap. Med. Assoc. J. 1997; 107: 3842. (in Japanese).
6. Dobrilla G, Comberlato M, Steele A, Vallaperta P. Drug treatment of functional dyspepsia. A meta-analysis of randomized controlled clinical trials. J. Clin. Gastroenterol. 1989; 11: 169-77.
7. Moayyedi P, Soo S, Deeks J, Delaney B, Innes M, Forman D. Pharmacological interventions for non-ulcer dyspepsia. Cochrane Database Syst. Rev. 2006; (4): CD001960.
8. Hongo M, Kanatsuka H, Sugawara A etal. Primary care in the treatment of functional gastrointestinal symptoms in Japan: prescription preferences and impression of results. Aliment. Pharmacol. Ther. 2005; 21 (Suppl. 2): 47-54.
9. Kato S, Morie T, Kon T, Yoshida N, Karasawa T, Matsumoto J. Novel benzamides as selective and potent gastrokinetic agents. 2. Synthesis and structure-activity relationships of 4-amino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2- morpholinyl]methyl] benzamide citrate (AS-4370) and related compounds. J. Med. Chem. 1991; 34: 616-24.
10. Yoshida N, Omoya H, Oka M, Furukawa K, Ito T, Karasawa T. AS-4370, a novel gastrokinetic agent free of dopamine D2 receptor antagonist properties. Arch. Int. Pharmacodyn. Ther. 1989; 300: 51-67.
11. Seto Y, Kawashima K, Yoshida N, Kaneko H. Inhibitory effect of mosapride citrate, a 5-HT4 receptor agonist, on gastric distension-induced visceral pain behavior and abdominal striated muscle contraction in conscious rats. Gastroenterology 2005; 128 (Suppl. 2): A671.
12. Fukuhara S, Bito S, Green J, Hsiao A, Kurokawa K. Translation, adaptation, and validation of the SF-36 Health Survey for use in Japan. J. Clin. Epidemiol. 1998; 51: 1037-44.
13. Wiklund I, Glise H, Jerndal P, Carlsson J, Talley NJ. Does endoscopy have a positive impact on quality of life in dyspepsia? Gastrointest. Endosc. 1998; 47: 449-54.
14. Talley NJ, Phillips SF. Non-ulcer dyspepsia: potential causes and pathophysiology. Ann. Intern. Med. 1988; 108: 865-79.
15. Talley NJ, Weaver AL, Zinsmeister AR, Melton LJ 3rd. Onset and disappearance of gastrointestinal symptoms and functional gastrointestinal disorders. Am. J. Epidemiol. 1992; 136: 165-77.
16. Hasebe T, Miwa T, Matsueda K. [The medical care guidelines for FD.] Clinica 1999; 26: 40-7. (in Japanese).
17. Kiyota K. [A study of the clinical epidemiology of non-ulcer dyspepsia (NUD).] J Japan Soc Gastro 1992; 89: 1973-81. (in Japanese).
18. Thomson AB, Barkun AN, Armstrong D etal. The prevalence of clinically significant endoscopic findings in primary care patients with uninvestigated dyspepsia: the Canadian Adult Dyspepsia Empiric Treatment-Prompt Endoscopy (CADET-PE) study. Aliment. Pharmacol. Ther. 2003; 17: 1481-91.
19. Quartero AO, de Wit NJ, Lodder AC, Numans ME, Smout AJ, Hoes AW. Disturbed solid-phase gastric emptying in functional dyspepsia: a meta-analysis. Dig. Dis. Sci. 1998; 43: 2028-33.
20. Yoshida N, Ito T, Karasawa T, Itoh Z. AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs. J. Pharmacol. Exp. Ther. 1991; 257: 781-7.
21. Oshiba S, Ashizawa S, Shirakabe H etal. Therapeutic effect of Ea-0671 on acute gastritis and acute exacerbation in chronic gastritis. Multicenter double-blind controlled study compared with cetraxate, mainly using endoscopic evaluation. Clin. Eval. (Rinsho Hyoka) 1988; 16: 25-48. (in Japanese).
22. Terano A, Hiraishi H, Ota S, Sugimoto T. Geranylgeranylacetone, a novel anti-ulcer drug, stimulates mucus synthesis and secretion in rat gastric cultured cells. Digestion 1986; 33: 206-10.
23. Veldhuyzen van Zanten SJ, Cleary C, Talley NJ etal. Drug treatment of functional dyspepsia: a systematic analysis of trial methodology with recommendations for design of future trials. Am. J. Gastroenterol. 1996; 91: 660-73.
24. Hallerback BI, Bommelaer G, Bredberg E etal. Dose finding study of mosapride in functional dyspepsia: a placebo-controlled, randomized study. Aliment. Pharmacol. Ther. 2002; 16: 959-67.
25. Fraser A, Delaney B, Moayyedi P. Symptom-based outcome measures for dyspepsia and GERD trials: a systematic review. Am. J. Gastroenterol. 2005; 100: 492-52.