Cortisol responses to emotional stress in men: Association with a functional polymorphism in the 5HTR2C gene

Biological Psychology

Volumn 89, Issue 1, 2012, Pages 94-98

  Brummett, Beverly H ^a   Kuhn, Cynthia M ^a   Boyle, Stephen H ^a   Babyak, Michael A ^a   Siegler, Ilene C ^a   Williams, Redford B ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

5HTR2C; Cardiovascular disease; Cortisol; Emotion; Hypothalamic pituitary axis; Rs6318; Serotonin; Stress

Indexed keywords

HYDROCORTISONE;

5HTR2C GENE; ADULT; ANGER; ARTICLE; DEPRESSION; EMOTIONAL STRESS; GENE; GENE ACTIVITY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ADOLESCENT; ADULT; CYSTEINE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHIATRIC STATUS RATING SCALES; RADIOIMMUNOASSAY; RECEPTOR, SEROTONIN, 5-HT2C; SERINE; STATISTICS AS TOPIC; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84155167009     PISSN: 03010511     EISSN: 18736246     Source Type: Journal    
DOI: 10.1016/j.biopsycho.2011.09.013     Document Type: Article

References (31)

1. Boyle S.H., Surwit R.S., Georgiades A., Brummett B.H., Helms M.J., Williams R.B., Barefoot J.C. Depressive symptoms, race and glucose concentrations: the role of cortisol as mediator. Diabetes Care 2007, 30:2484-2488.
2. Burroughs A.R., Visscher A.W., Haney T.L., Efland J.R., Barefoot J.C., Williams R.B., Siegler I.C. Community recruitment process by race, gender, and ses gradient: lessons learned from the community health and stress evaluation (chase) study experience. Journal of Community Health 2003, 28:421-437.
3. Davey-Smith G., Ben-Shlomo Y., Beswick A., Yarnell J., Lightman S., Elwood P. Cortisol, testosterone and coronary heart disease: prospective evidence from the Caephilly Study. Circulation 2005, 112:332-340.
4. Drago A., Serretti A. Focus on HTR2C: a possible suggestion for genetic studies of complex disorders. American Journal of Medical Genetics: Part B Neuropsychiatric Genetics 2009, 150B(5):601-637.
5. Dinan T.G. Serotonin and the regulation of hypothalamic-pituitary-adrenal axis function. Life Science 1996, 58:1683-1694.
6. Hamer M., O'Donnell K., Lahiri A., Steptoe A. Salivary cortisol responses to mental stress are associated with coronary artery calcification in healthy men and women. European Heart Journal 2010, 31(4):424-429.
7. Heisler L.K., Pronchuk N., Nonogaki K., Zhou L., Raber J., Tung L., Yeo G.S., O'Rahilly S., Colmers W.F., Elmquist J.K., Tecott L.H. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. Journal of Neuroscience 2007, 27(26):6956-6964.
8. Hinkelmann K., Botzenhardt J., Muhtz C., Agorastos A., Wiedemann K., Kellner M., Otte C. Sex differences of salivary cortisol secretion in patients with major depression. Stress 2011, (Epub ahead of print).
9. Karlamangla A.S., Singer B.H., Chodosh J., McEwen B.S., Seeman T.E. Urinary cortisol excretion as a predictor of incident cognitive impairment. Neurobiology of Aging 2005, 26(Suppl. 1):80-84.
10. Kring S.I., Brummett B.H., Barefoot J., Garrett M.E., Ashley-Koch A.E., Boyle S.H., Siegler I.C., Sørensen T.I., Williams R.B. Impact of psychological stress on the associations between apolipoprotein E variants and metabolic traits: findings in an American sample of caregivers and controls. Psychosomatic Medicine 2010, 72(5):427-433.
11. Kühn K.U., Joe A.Y., Meyer K., Reichmann K., Maier W., Rao M.L., Reinhardt M.J., Biersack H.J., Quednow B.B. Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor. Pharmacopsychiatry 2004, 37(6):286-291.
12. Kühn K.U., Quednow B.B., Bagli M., Meyer K., Feuchtl A., Westheide J., Frahnert C., Maier W., Rao M.L. Allelic variants of the serotonin(2C) receptor and neuroendocrinological responses to the serotonin(2C) receptor agonist m-chlorophenylpiperazine in healthy male volunteers. Pharmacopsychiatry 2002, 35(6):226-230.
13. Kumari M., Badrick E., Sacker A., Kirschbaum C., Marmot M., Chandola T. Identifying patterns in cortisol secretion in an older population. Findings from the Whitehall II study. Psychoneuroendocrinology 2010, 35(7):1091-1099.
14. Lappalainen J., Zhang L., Dean M., Oz M., Ozaki N., Yu D.H., Virkkunen M., Weight F., Linnoila M., Goldman D. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). Genomics 1995, 27(2):274-279.
15. Lerer B., Macciardi F., Segman R.H., Adolfsson R., Blackwood D., Blairy S., Del Favero J., Dikeos D.G., Kaneva R., Lilli R., Massat I., Milanova V., Muir W., Noethen M., Oruc L., Petrova T., Papadimitriou G.N., Rietschel M., Serretti A., Souery D., Van Gestel S., Van Broeckhoven C., Mendlewicz J. Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder. Molecular Psychiatry 2001, 6(5):579-585.
16. Lowry C.A. Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis. Journal of Neuroendocrinology 2002, 14(11):911-923.
17. McNair D.M., Lorr M. An analysis of mood in neurotics. Journal of Abnormal and Social Psychology 1964, 69:620-627.
18. Okada M., Northup J.K., Ozaki N., Russell J.T., Linnoila M., Goldman D. Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution. Molocular Psychiatry 2004, 9(1):55-64.
19. Pereg D., Gow R., Mosseri M., Lishner M., Rieder M., Van Uum S., Koren G. Hair cortisol and the risk for acute myocardial infarction in adult men. Stress 2011, 14(1):73-81.
20. Quested D.J., Whale R., Sharpley A.L., McGavin C.L., Crossland N., Harrison P.J., Cowen P.J. Allelic variation in the 5-HT2C receptor (HTR2C) and functional responses to the 5-HT2C receptor agonist, m-chlorophenylpiperazine. Psychopharmacology (Berl) 1999, 144(3):306-307.
21. Raff H., Raff J.L., Duthie E.H., Wilson C.R., Sasse E.A., Rudman I., Mattson D. Elevated salivary cortisol in the evening in healthy elderly men and women: correlation with bone mineral density. Journal of Gerontology Series A: Biological Science and Medical Science 1999, 54(9):M479-M483.
22. Reynolds R.M., Labad J., Strachan M.W.J., Braun A., Fowkes F.G.R., Lee A.J., Frier B.M., Seckl J.R., Walker B.R., Price J.F. Elevated fasting plasma cortisol is associated with ischemic heart disease and its risk factors in people with type 2 diabetes: the Edinburgh type 2 diabetes study. Journal of Clinical Endocrinology and Metabolism 2010, 95(4):1602-1608.
23. Rosmond R. Role of stress in the pathogenesis of the metabolic syndrome. Psychoneuroendocrinology 2005, 30(1):1-10.
24. Rosmond R., Wallerius S., Wanger P., Martin L., Holm G., Bjorntorp P. A 5-year follow-up study of disease incidence in men with an abnormal hormone pattern. Journal of Internal Medicine 2003, 254(4):386-390.
25. Steyerberg E.W. Clinical Prediction Models 2009, Springer, New York.
26. Suarez E., Kuhn C., Shanberg S., Williams R., Zimmerman E. Neuroendocrine, cardiovascular, and emotional responses of hostile men: the role of interpersonal challenge. Psychosomatic Medicine 1998, 60:78-88.
27. Valley C.M., Willard H.F. Genomic and epigenomic approaches to the study of X chromosome inactivation. Current Opinion in Genetics and Development 2006, 16:240-245.
28. Varadhan R., Walston J., Cappola A.R., Carlson M.C., Wand G.S., Fried L.P. Higher levels and blunted diurnal variation of cortisol in frail older women. Journal of Gerontology Series A: Biological Science and Medical Science 2008, 63(2):190-195.
29. Williams R.B. Psychosocial and biobehavioral factors and their interplay in coronary heart disease. Annual Review of Clinical Psychology 2008, 4:349-365.
30. Williams R.B., Marchuk D.A., Gadde K.M., Barefoot J.C., Grichnik K., Helms M.J., Kuhn C.M., Lewis J.G., Schanberg S.M., Stafford-Smith M., Suarez E.C., Clary G.L., Svenson I.K., Siegler I.C. Central nervous system serotonin function and cardiovascular responses to stress. Psychosomatic Medicine 2001, 63(2):300-305.
31. Williams R.B., Marchuk D.A., Gadde K.M., Barefoot J.C., Grichnik K., Helms M.J., Kuhn C.M., Lewis J.G., Schanberg S.M., Stafford-Smith M., Suarez E.C., Clary G.L., Svenson I.K., Siegler I.C. Serotonin-related gene polymorphisms and central nervous system serotonin function. Neuropsychopharmacology 2003, 28(3):533-541.