Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: Possible effect in the ovarian follicular mass of their daughters

Fertility and Sterility

Volumn 97, Issue 1, 2012, Pages 218-224

  Crisosto, Nicolás ^a   Echiburú, Bárbara ^a   Maliqueo, Manuel ^a   Pérez, Virginia ^a   Ladrón De Guevara, Amanda ^a   Preisler, Jessica ^a   Sánchez, Fernando ^a   Sir Petermann, Teresa ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

antim llerian hormone; metformin; ovarian function; Polycystic ovary syndrome

Indexed keywords

ANDROGEN; ESTRADIOL; GONADOTROPIN; INSULIN; METFORMIN; MUELLERIAN INHIBITING FACTOR; SEX HORMONE; SEX HORMONE BINDING GLOBULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DAUGHTER; FEMALE; FOLLICLE CYST; GONADORELIN TEST; HUMAN; HYPERANDROGENISM; HYPERINSULINEMIA; INFANCY; INFANT; NEWBORN; OUTCOME ASSESSMENT; OVARIAN FOLLICULAR MASS; OVARY FOLLICLE; OVARY FUNCTION; OVARY POLYCYSTIC DISEASE; PREGNANCY; PRIORITY JOURNAL;

ADULT; ANTI-MULLERIAN HORMONE; BIRTH WEIGHT; DIABETES, GESTATIONAL; FEMALE; FERTILITY AGENTS, FEMALE; HUMANS; HYPERANDROGENISM; HYPERINSULINISM; HYPOGLYCEMIC AGENTS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; INSULIN; LEUPROLIDE; METFORMIN; OVARIAN FOLLICLE; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; TESTOSTERONE; YOUNG ADULT;

EID: 84155164455     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.10.002     Document Type: Article

References (45)

1. A. Dunaif Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis Endocr Rev 18 1997 774 800 (Pubitemid 28009567)
2. E. Carmina, and R.A. Lobo Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women J Clin Endocrinol Metab 84 1999 1897 1899 (Pubitemid 30647006)
3. R. Azziz, K.S. Woods, R. Reyna, T.J. Key, E.S. Knochenhauer, and B.O. Yildiz The prevalence and features of the polycystic ovary syndrome in an unselected population J Clin Endocrinol Metab 89 2004 2745 2749 (Pubitemid 38766360)
4. W.A. March, V.M. Moore, K.J. Willson, D.I. Phillips, R.J. Norman, and M.J. Davies The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria Hum Reprod 25 2010 544 551
5. S. Jonard, Y. Robert, C. Cortet-Rudelli, P. Pigny, C. Decanter, and D. Dewailly Ultrasound examination of polycystic ovaries: is it worth counting the follicles? Hum Reprod 18 2003 598 603 (Pubitemid 36329332)
6. L.J. Webber, S. Stubbs, J. Stark, G.H. Trew, R. Margara, and K. Hardy Formation and early development of follicles in the polycystic ovary Lancet 362 2003 1017 1021 (Pubitemid 37186878)
7. T. Sir-Petermann, E. Codner, M. Maliqueo, B. Echiburu, C. Hitschfeld, and N. Crisosto Increased anti-mullerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome J Clin Endocrinol Metab 91 2006 3105 3109 (Pubitemid 44271764)
8. N. Crisosto, E. Codner, M. Maliqueo, B. Echiburu, F. Sanchez, and F. Cassorla Anti-Mullerian hormone levels in peripubertal daughters of women with polycystic ovary syndrome J Clin Endocrinol Metab 92 2007 2739 2743 (Pubitemid 47037384)
9. N. Xita, and A. Tsatsoulis Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies J Clin Endocrinol Metab 91 2006 1660 1666
10. V. Padmanabhan, A. Veiga-Lopez, D.H. Abbott, S.E. Recabarren, and C. Herkimer Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females Endocrinology 151 2010 595 605
11. D.H. Abbott, D.K. Barnett, C.M. Bruns, and D.A. Dumesic Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome? Hum Reprod Update 11 2005 357 374 (Pubitemid 40895465)
12. T. Sir-Petermann, M. Maliqueo, B. Angel, H.E. Lara, F. Perez-Bravo, and S.E. Recabarren Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization Hum Reprod 17 2002 2573 2579 (Pubitemid 35174106)
13. T. Sir-Petermann, B. Echiburú, M.M. Maliqueo, N. Crisosto, F. Sanchez, and C. Hitschfeld Serum adiponectin and lipid concentrations in pregnant women with polycystic ovary syndrome Hum Reprod 22 2007 1830 1836 (Pubitemid 47062748)
14. T. Sir-Petermann, C. Hitchsfeld, M. Maliqueo, E. Codner, B. Echiburu, and R. Gazitua Birth weight in offspring of mothers with polycystic ovarian syndrome Hum Reprod 20 2005 2122 2126 (Pubitemid 41418494)
15. A. Gougeon Regulation of ovarian follicular development in primates: facts and hypotheses Endocr Rev 17 1996 121 155 (Pubitemid 26119956)
16. C.J. Glueck, N. Goldenberg, P. Wang, and M. Loftspring Sherman. Metformin during pregnancy reduces insulin, insulin resistance, insulin secretion, weight, testosterone and development of gestational diabetes: prospective longitudinal assessment of women with polycystic ovary syndrome from preconception throughout pregnancy Hum Reprod 19 2004 510 521 (Pubitemid 38344509)
17. G. Juez Intrauterine growth curve for the appropriate diagnosis of intrauterine growth retardation Rev Med Chile 117 1989 1311
18. G. Juez, E. Lucero, P. Ventura-Junca, H. Gonzalez, J.L. Tapia, and A. Winter Intrauterine growth in Chilean middle class newborn infants Rev Chil Pediatr 60 1989 198 202
19. V. Mericq, K.K. Ong, R. Bazaes, V. Pena, A. Avila, and T. Salazar Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children Diabetologia 48 2005 2609 2614 (Pubitemid 41738229)
20. J.K. Zawadzky, and A. Dunaif Diagnostic criteria for polycystic ovary syndrome: toward a rational approach J.M. Hershmann, Current issues in endocrinology and metabolism 1992 Blackwell Boston 377 384
21. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) Hum Reprod 19 2004 41 47
22. J. Adams, D.W. Polson, and S. Franks Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism Br Med J (Clin Res Ed) 293 1986 355 359 (Pubitemid 16034121)
23. T. Sir-Petermann, L. Devoto, M. Maliqueo, P. Peirano, S.E. Recabarren, and L. Wildt Resumption of ovarian function during lactational amenorrhoea in breastfeeding women with polycystic ovarian syndrome: endocrine aspects Hum Reprod 16 2001 1603 1610 (Pubitemid 32761738)
24. Report of a WHO Consultation. Definition, diagnosis and classification of diabetes mellitus and its complications. Part I: Diagnosis and classification of diabetes mellitus 1999 Department of Noncommunicable Disease Surveillance, World Health Organization Geneva
25. M. Matsuda, and R.A. DeFronzo Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp Diabetes Care 22 1999 1462 1470 (Pubitemid 29418240)
26. R.V.C. Youlton Growth patterns in height and weight in children aged 0 to 17 years and cranial circumference in children aged 0 to 2 years from medium-high and high socioeconomic status in Santiago. Comparison with growth in children from medium low and low status in the Northern area of Santiago Rev Chil Pediatr Spec Iss 1990 1 22
27. T. Sir-Petermann, C. Hitchsfeld, E. Codner, M. Maliqueo, G. Iniguez, and B. Echiburu Gonadal function in low birth weight infants: a pilot study J Pediatr Endocrinol Metab 20 2007 405 414 (Pubitemid 46865046)
28. T. Sir-Petermann, L. Marquez, M. Carcamo, C. Hitschfeld, E. Codner, and M. Maliqueo Effects of birth weight on antimullerian hormone serum concentrations in infant girls J Clin Endocrinol Metab 95 2010 903 910
29. T. Sir-Petermann, E. Codner, V. Pérez, B. Echiburú, M. Maliqueo, and A. Ladrón de Guevara Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome J Clin Endocrinol Metab 94 2009 1923 1930
30. R.L. Rosenfield Is polycystic ovary syndrome a neuroendocrine or an ovarian disorder? Clin Endocrinol (Oxf) 47 1997 423 424 (Pubitemid 27452060)
31. S.E. Recabarren, T. Sir-Petermann, R. Rios, M. Maliqueo, B. Echiburú, and R. Smith Pituitary and testicular function in sons of women with polycystic ovary syndrome from infancy to adulthood J Clin Endocrinol Metab 93 2008 3318 3324
32. A. Falbo, M. Rocca, T. Russo, A. d'Ettore, A. Tolino, and F. Zullo Changes in androgens and insulin sensitivity indexes throughout pregnancy in women with polycystic ovary syndrome (PCOS): relationships with adverse outcomes J Ovarian Res 2010 13;3:23
33. E. Vanky, S. Stridsklev, R. Heimstad, P. Romundstad, K. Skogøy, and O. Kleggetveit Metformin versus placebo from first trimester to delivery in polycystic ovary syndrome: a randomized, controlled multicenter study J Clin Endocrinol Metab 95 2010 E448 E455
34. T. Jansson Maternal hormones linking maternal body mass index and dietary intake to birth weight Am J Clin Nutr 87 2008 1743 1749 (Pubitemid 351872638)
35. R. Homburg, and A. Amsterdam Polysystic ovary syndrome - loss of the apoptotic mechanism in the ovarian follicles? J Endocrinol Invest 21 1998 552 557 (Pubitemid 28532462)
36. L.G. Nardo, A.P. Yates, S.A. Roberts, P. Pemberton, and I. Laing The relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in nonobese subfertile women with and without polycystic ovary syndrome Hum Reprod 24 2009 2917 2923
37. V. Padmanabhan, M. Manikkam, S. Recabarren, and D. Foster Prenatal testosterone excess programs reproductive and metabolic dysfunction in the female Mol Cell Endocrinol 246 2006 165 174 (Pubitemid 43238412)
38. Maliqueo M, Amigo P, Echiburu B, Oliva S, Crisosto N, Lara HE, et al. 3 Beta-hydroxysteroid deshydrogenase type 1 (3 beta-HSD-1) and P450 aromatase (P450 AROM) activities in placental tissue from women with polycystic ovary syndrome. Sixth annual meeting of the Androgen Excess and PCOS Society, 2008, San Francisco, CA.
39. J.E. Nestler Insulin and insulin-like growth factor-I stimulate the 3 beta-hydroxysteroid dehydrogenase activity of human placental cytotrophoblasts Endocrinology 125 1989 2127 2133 (Pubitemid 19258651)
40. J.E. Nestler Regulation of the aromatase activity of human placental cytotrophoblasts by insulin, insulin-like growth factor-I, and -II J Steroid Biochem Mol Biol 44 1993 449 457 (Pubitemid 23126616)
41. G.R. Attia, W.E. Rainey, and B.R. Carr Metformin directly inhibits androgen production in human thecal cells Fertil Steril 76 2001 517 524
42. R. Mansfield, R. Galea, M. Brincat, D. Hole, and H. Mason Metformin has direct effects on human ovarian steroidogenesis Fertil Steril 79 2003 956 962 (Pubitemid 36385020)
43. T. Misugi, K. Ozaki, K. El Beltagy, O. Tokuyama, K. Honda, and O. Ishiko Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats Gynecol Obstet Invest 61 2006 208 215
44. S.M. Carlsen, and E. Vanky Metformin influence on hormone levels at birth, in PCOS mothers and their newborns Hum Reprod 25 2010 786 790
45. B. Freedman Equipoise and the ethics of clinical research N Engl J Med 317 1987 141 145 (Pubitemid 17092151)