Characterization of the cellular action of the MSK inhibitor SB-747651A

Biochemical Journal

Volumn 441, Issue 1, 2012, Pages 347-357

  Naqvi, Shaista ^a   Macdonald, Andrew ^a,c   Mccoy, Claire E ^a,d   Darragh, Joanne ^a   Reith, Alastair D ^b   Arthur, J Simon C ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

CAMP response element binding protein (CREB); Mitogen and stress activated kinase (MSK); Mitogen activated protein kinase (MAPK); P38; Ribosomal s6 kinase (RSK)

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CYTOKINE; DOUBLE STRANDED RNA DEPENDENT PROTEIN KINASE 2; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN AND STRESS ACTIVATED KINASE 1; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE INHIBITOR; RHO ASSOCIATED PROTEIN KINASE 2; RIBOSOMAL S6 KINASE 1; S6 KINASE; SB 747651 A; SB 747651A; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UNINDEXED SEQUENCE; WILD TYPE;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE; CYTOKINES; ENZYME INHIBITORS; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INDOLES; ISOQUINOLINES; MACROPHAGES; MICE; MOLECULAR STRUCTURE; OXADIAZOLES; RATS; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SULFONAMIDES;

EID: 84055223557     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110970     Document Type: Article

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