Comprehensive mechanism-based antibody pharmacokinetic modeling

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

Volumn , Issue , 2011, Pages 4318-4323

  Chabot, Jeffrey R ^a   Dettling, Danielle E ^a   Jasper, Paul J ^b   Gomes, Bruce C ^a  

^a PFIZER INC   (United States)

^b RES Group Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ENDOTHELIAL BARRIERS; HUMAN DISEASE; PHARMACOKINETIC MODEL; PHARMACOKINETIC MODELING; PHARMACOLOGICAL EFFECTS; PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELS; TRANSCYTOSIS;

ANTIBODIES; DYNAMICS; OPTIMIZATION; PHARMACOKINETICS; TISSUE;

PHYSIOLOGICAL MODELS;

ANTIBODY;

ARTICLE; METABOLISM; PHARMACOKINETICS; THEORETICAL MODEL;

ANTIBODIES; MODELS, THEORETICAL; PHARMACOKINETICS;

EID: 84055217372     PISSN: 1557170X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/IEMBS.2011.6091072     Document Type: Conference Paper

References (18)

1. D. Venturoli and B. Rippe, "Ficoll and dextran vs. globular proteins as probes for testing glomerular permselectivity: effects of molecular size, shape, charge, and deformability," Am J Physiol Renal Physiol, vol. 288, pp. F605-13, Apr 2005.
2. A. Garg and J. P. Balthasar, "Physiologically-based pharmacokinetic (PBPK) model to predict IgG tissue kinetics in wild-type and FcRnknockout mice," J Pharmacokinet Pharmacodyn, vol. 34, pp. 687-709, Oct 2007.
3. J. P. Davda, M. Jain, S. K. Batra, P. R. Gwilt, and D. H. Robinson, "A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs," Int Immunopharmacol, vol. 8, pp. 401-13, Mar 2008.
4. R. P. Junghans and C. L. Anderson, "The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor," Proc Natl Acad Sci U S A, vol. 93, pp. 5512-6, May 28 1996.
5. O. D. Holton, 3rd, C. D. Black, R. J. Parker, D. G. Covell, J. Barbet, S. M. Sieber, M. J. Talley, and J. N. Weinstein, "Biodistribution of monoclonal IgG1, F(ab')2, and Fab' in mice after intravenous injection. Comparison between anti-B cell (anti-Lyb8.2) and irrelevant (MOPC-21) antibodies," J Immunol, vol. 139, pp. 3041-9, Nov 1 1987.
6. J. L. Fahey and A. G. Robinson, "Factors Controlling Serum Gamma- Globulin Concentration," J Exp Med, vol. 118, pp. 845-68, Nov 1 1963.
7. B. Davies and T. Morris, "Physiological parameters in laboratory animals and humans," Pharm Res, vol. 10, pp. 1093-5, Jul 1993.
8. A. C. Guyton and J. E. Hall, Human physiology and mechanisms of disease, 6 ed.: Saunders, 1996.
9. J. B. Bassingthwaighte, "A concurrent flow model for extraction during transcapillary passage," Circ Res, vol. 35, pp. 483-503, Sep 1974.
10. C. Crone and D. G. Levitt, "Capillary permeability to small solutes.," in The Microcirculation, Handbook of Physiology E. M. Renkin and C. C. Michel, Eds. Bethesda: American Physiological Society, 1984, pp. 411-466.
11. M. J. Eppihimer, J. Russell, R. Langley, G. Vallien, D. C. Anderson, and D. N. Granger, "Differential expression of platelet-endothelial cell adhesion molecule-1 (PECAM-1) in murine tissues," Microcirculation, vol. 5, pp. 179-88, 1998.
12. I. C. MacDonald, E. E. Schmidt, and A. C. Groom, "The high splenic hematocrit: a rheological consequence of red cell flow through the reticular meshwork," Microvasc Res, vol. 42, pp. 60-76, Jul 1991.
13. A. Blouin, R. P. Bolender, and E. R. Weibel, "Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study," J Cell Biol, vol. 72, pp. 441-55, Feb 1977.
14. J. Zhou, J. E. Johnson, V. Ghetie, R. J. Ober, and E. S. Ward, "Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G," J Mol Biol, vol. 332, pp. 901-13, Sep 26 2003.
15. Z. Qi, I. Whitt, A. Mehta, J. Jin, M. Zhao, R. C. Harris, A. B. Fogo, and M. D. Breyer, "Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance," Am J Physiol Renal Physiol, vol. 286, pp F590-6, Mar 2004.
16. S. Mizuiri, I. Hayashi, M. Takano, R. Ban, T. Ohara, Y. Sasaki, and A. Hasegawa, "Fractional mean transit time in transplanted kidneys studied by technetium-99m-DTPA: comparison of clinical and biopsy findings," J Nucl Med, vol. 35, pp. 84-9, Jan 1994.
17. A. Zarzuelo, A. Sanchez-Navarro, F. G. Lopez, and J. M. Lanao, "Influence of dose on the disposition kinetics of netilmicin in the isolated kidney of the rat," Eur J Drug Metab Pharmacokinet, vol. 27, pp. 127-33, Apr-Jun 2002.
18. K. Kim, S. H. Kim, C. W. Yang, C. Li, Y. A. Cheung, S. Y. Lee, H. S. Sohn, and S. K. Chung, "Differentiation between acute cyclosporine nephrotoxicity and acute tubular necrosis using enalaprilat renal scintigraphy in rats," Invest Radiol, vol. 38, pp. 473-81, Aug 2003.