메뉴 건너뛰기




Volumn 6, Issue 12, 2011, Pages

Molecular mechanisms of bortezomib resistant adenocarcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BORTEZOMIB; CARFILZOMIB; CYCLOHEXIMIDE; CYSTEINE; IMMUNOPROTEASOME; PHENYLALANINE; PROTEASOME; PROTEASOME BETA5 SUBUNIT; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BORONIC ACID DERIVATIVE; PYRAZINE DERIVATIVE;

EID: 84055182497     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027996     Document Type: Article
Times cited : (64)

References (37)
  • 1
    • 11244309014 scopus 로고    scopus 로고
    • Proteolysis: from the lysosome to ubiquitin and the proteasome
    • Ciechanover A, (2005) Proteolysis: from the lysosome to ubiquitin and the proteasome. Nat Rev Mol Cell Biol 6: 79-87.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 79-87
    • Ciechanover, A.1
  • 3
    • 53049083867 scopus 로고    scopus 로고
    • Mechanisms of proteasome inhibitor action and resistance in cancer
    • McConkey DJ, Zhu K, (2008) Mechanisms of proteasome inhibitor action and resistance in cancer. Drug Resist Updat 11: 164-179.
    • (2008) Drug Resist Updat , vol.11 , pp. 164-179
    • McConkey, D.J.1    Zhu, K.2
  • 4
    • 0036181371 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor PS-341
    • Adams J, (2002) Development of the proteasome inhibitor PS-341. Oncologist 7: 9-16.
    • (2002) Oncologist , vol.7 , pp. 9-16
    • Adams, J.1
  • 5
    • 50249092779 scopus 로고    scopus 로고
    • Development of proteasome inhibitors in oncology and autoimmune diseases
    • Bennett MK, Kirk CJ, (2008) Development of proteasome inhibitors in oncology and autoimmune diseases. Curr Opin Drug Discov Devel 11: 616-625.
    • (2008) Curr Opin Drug Discov Devel , vol.11 , pp. 616-625
    • Bennett, M.K.1    Kirk, C.J.2
  • 6
    • 77649237033 scopus 로고    scopus 로고
    • Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy
    • Dick LR, Fleming PE, (2010) Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy. Drug Discov Today 15: 243-249.
    • (2010) Drug Discov Today , vol.15 , pp. 243-249
    • Dick, L.R.1    Fleming, P.E.2
  • 7
    • 61849152933 scopus 로고    scopus 로고
    • Many facets of bortezomib resistance/susceptibility
    • Kumar S, Rajkumar SV, (2008) Many facets of bortezomib resistance/susceptibility. Blood 112: 2177-2178.
    • (2008) Blood , vol.112 , pp. 2177-2178
    • Kumar, S.1    Rajkumar, S.V.2
  • 8
    • 70450227260 scopus 로고    scopus 로고
    • Proteasome inhibitors in the treatment of multiple myeloma
    • Shah JJ, Orlowski RZ, (2009) Proteasome inhibitors in the treatment of multiple myeloma. Leukemia 23: 1964-1979.
    • (2009) Leukemia , vol.23 , pp. 1964-1979
    • Shah, J.J.1    Orlowski, R.Z.2
  • 9
    • 34147129816 scopus 로고    scopus 로고
    • Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib
    • Mulligan G, Mitsiades C, Bryant B, Zhan F, Chng WJ, et al. (2007) Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib. Blood 109: 3177-3188.
    • (2007) Blood , vol.109 , pp. 3177-3188
    • Mulligan, G.1    Mitsiades, C.2    Bryant, B.3    Zhan, F.4    Chng, W.J.5
  • 10
    • 33845532759 scopus 로고    scopus 로고
    • Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells
    • Kraus M, Ruckrich T, Reich M, Gogel J, Beck A, et al. (2007) Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells. Leukemia 21: 84-92.
    • (2007) Leukemia , vol.21 , pp. 84-92
    • Kraus, M.1    Ruckrich, T.2    Reich, M.3    Gogel, J.4    Beck, A.5
  • 11
    • 52049086674 scopus 로고    scopus 로고
    • Overexpression of the PSMB5 gene contributes to bortezomib resistance in T-lymphoblastic lymphoma/leukemia cells derived from Jurkat line
    • Lu S, Chen Z, Yang J, Chen L, Gong S, et al. (2008) Overexpression of the PSMB5 gene contributes to bortezomib resistance in T-lymphoblastic lymphoma/leukemia cells derived from Jurkat line. Exp Hematol 36: 1278-1284.
    • (2008) Exp Hematol , vol.36 , pp. 1278-1284
    • Lu, S.1    Chen, Z.2    Yang, J.3    Chen, L.4    Gong, S.5
  • 12
    • 47949089799 scopus 로고    scopus 로고
    • Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line
    • Lu S, Yang J, Song X, Gong S, Zhou H, et al. (2008) Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. J Pharmacol Exp Ther 326: 423-431.
    • (2008) J Pharmacol Exp Ther , vol.326 , pp. 423-431
    • Lu, S.1    Yang, J.2    Song, X.3    Gong, S.4    Zhou, H.5
  • 13
    • 67049107847 scopus 로고    scopus 로고
    • Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line
    • Lu S, Yang J, Chen Z, Gong S, Zhou H, et al. (2009) Different mutants of PSMB5 confer varying bortezomib resistance in T lymphoblastic lymphoma/leukemia cells derived from the Jurkat cell line. Exp Hematol 37: 831-837.
    • (2009) Exp Hematol , vol.37 , pp. 831-837
    • Lu, S.1    Yang, J.2    Chen, Z.3    Gong, S.4    Zhou, H.5
  • 14
    • 53049106912 scopus 로고    scopus 로고
    • Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein
    • Oerlemans R, Franke NE, Assaraf YG, Cloos J, van ZI, et al. (2008) Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein. Blood 112: 2489-2499.
    • (2008) Blood , vol.112 , pp. 2489-2499
    • Oerlemans, R.1    Franke, N.E.2    Assaraf, Y.G.3    Cloos, J.4    van, Z.I.5
  • 15
    • 67349212864 scopus 로고    scopus 로고
    • Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells
    • Ruckrich T, Kraus M, Gogel J, Beck A, Ovaa H, et al. (2009) Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells. Leukemia 23: 1098-1105.
    • (2009) Leukemia , vol.23 , pp. 1098-1105
    • Ruckrich, T.1    Kraus, M.2    Gogel, J.3    Beck, A.4    Ovaa, H.5
  • 16
    • 70350708810 scopus 로고    scopus 로고
    • Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome
    • Parlati F, Lee SJ, Aujay M, Suzuki E, Levitsky K, et al. (2009) Carfilzomib can induce tumor cell death through selective inhibition of the chymotrypsin-like activity of the proteasome. Blood 114: 3439-3447.
    • (2009) Blood , vol.114 , pp. 3439-3447
    • Parlati, F.1    Lee, S.J.2    Aujay, M.3    Suzuki, E.4    Levitsky, K.5
  • 17
    • 53049106912 scopus 로고    scopus 로고
    • Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein
    • Oerlemans R, Franke NE, Assaraf YG, Cloos J, van ZI, et al. (2008) Molecular basis of bortezomib resistance: proteasome subunit beta5 (PSMB5) gene mutation and overexpression of PSMB5 protein. Blood 112: 2489-2499.
    • (2008) Blood , vol.112 , pp. 2489-2499
    • Oerlemans, R.1    Franke, N.E.2    Assaraf, Y.G.3    Cloos, J.4    van, Z.I.5
  • 18
    • 63849281664 scopus 로고    scopus 로고
    • The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition
    • Bianchi G, Oliva L, Cascio P, Pengo N, Fontana F, et al. (2009) The proteasome load versus capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. Blood 113: 3040-3049.
    • (2009) Blood , vol.113 , pp. 3040-3049
    • Bianchi, G.1    Oliva, L.2    Cascio, P.3    Pengo, N.4    Fontana, F.5
  • 19
    • 77955712506 scopus 로고    scopus 로고
    • Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress
    • Ri M, Iida S, Nakashima T, Miyazaki H, Mori F, et al. (2010) Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress. Leukemia 24: 1506-1512.
    • (2010) Leukemia , vol.24 , pp. 1506-1512
    • Ri, M.1    Iida, S.2    Nakashima, T.3    Miyazaki, H.4    Mori, F.5
  • 20
    • 28844435438 scopus 로고    scopus 로고
    • No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib
    • Politou M, Karadimitris A, Terpos E, Kotsianidis I, Apperley JF, et al. (2006) No evidence of mutations of the PSMB5 (beta-5 subunit of proteasome) in a case of myeloma with clinical resistance to Bortezomib. Leuk Res 30: 240-241.
    • (2006) Leuk Res , vol.30 , pp. 240-241
    • Politou, M.1    Karadimitris, A.2    Terpos, E.3    Kotsianidis, I.4    Apperley, J.F.5
  • 21
    • 34447116376 scopus 로고    scopus 로고
    • Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome
    • Demo SD, Kirk CJ, Aujay MA, Buchholz TJ, Dajee M, et al. (2007) Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome. Cancer Res 67: 6383-6391.
    • (2007) Cancer Res , vol.67 , pp. 6383-6391
    • Demo, S.D.1    Kirk, C.J.2    Aujay, M.A.3    Buchholz, T.J.4    Dajee, M.5
  • 22
    • 33845532759 scopus 로고    scopus 로고
    • Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells
    • Kraus M, Ruckrich T, Reich M, Gogel J, Beck A, et al. (2007) Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells. Leukemia 21: 84-92.
    • (2007) Leukemia , vol.21 , pp. 84-92
    • Kraus, M.1    Ruckrich, T.2    Reich, M.3    Gogel, J.4    Beck, A.5
  • 23
    • 33644845743 scopus 로고    scopus 로고
    • Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome
    • Groll M, Berkers CR, Ploegh HL, Ovaa H, (2006) Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure 14: 451-456.
    • (2006) Structure , vol.14 , pp. 451-456
    • Groll, M.1    Berkers, C.R.2    Ploegh, H.L.3    Ovaa, H.4
  • 24
    • 79955498420 scopus 로고    scopus 로고
    • Non-proteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events
    • Arastu-Kapur S, Anderl JL, Kraus M, Parlati F, Shenk KD, et al. (2011) Non-proteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res.
    • (2011) Clin Cancer Res
    • Arastu-Kapur, S.1    Anderl, J.L.2    Kraus, M.3    Parlati, F.4    Shenk, K.D.5
  • 25
    • 60849097304 scopus 로고    scopus 로고
    • Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC
    • Doherty MK, Hammond DE, Clague MJ, Gaskell SJ, Beynon RJ, (2009) Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC. J Proteome Res 8: 104-112.
    • (2009) J Proteome Res , vol.8 , pp. 104-112
    • Doherty, M.K.1    Hammond, D.E.2    Clague, M.J.3    Gaskell, S.J.4    Beynon, R.J.5
  • 26
    • 34548566134 scopus 로고    scopus 로고
    • Intermediate-type 20 S proteasomes in HeLa cells: "asymmetric" subunit composition, diversity and adaptation
    • Klare N, Seeger M, Janek K, Jungblut PR, Dahlmann B, (2007) Intermediate-type 20 S proteasomes in HeLa cells: "asymmetric" subunit composition, diversity and adaptation. J Mol Biol 373: 1-10.
    • (2007) J Mol Biol , vol.373 , pp. 1-10
    • Klare, N.1    Seeger, M.2    Janek, K.3    Jungblut, P.R.4    Dahlmann, B.5
  • 27
    • 38749115417 scopus 로고    scopus 로고
    • Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits
    • Busse A, Kraus M, Na IK, Rietz A, Scheibenbogen C, et al. (2008) Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits. Cancer 112: 659-670.
    • (2008) Cancer , vol.112 , pp. 659-670
    • Busse, A.1    Kraus, M.2    Na, I.K.3    Rietz, A.4    Scheibenbogen, C.5
  • 28
    • 0141704418 scopus 로고    scopus 로고
    • The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
    • Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, et al. (2003) The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem 278: 35869-35877.
    • (2003) J Biol Chem , vol.278 , pp. 35869-35877
    • Kisselev, A.F.1    Garcia-Calvo, M.2    Overkleeft, H.S.3    Peterson, E.4    Pennington, M.W.5
  • 29
    • 0033168717 scopus 로고    scopus 로고
    • Eukaryotic 20S proteasome catalytic subunit propeptides prevent active site inactivation by N-terminal acetylation and promote particle assembly
    • Arendt CS, Hochstrasser M, (1999) Eukaryotic 20S proteasome catalytic subunit propeptides prevent active site inactivation by N-terminal acetylation and promote particle assembly. EMBO J 18: 3575-3585.
    • (1999) EMBO J , vol.18 , pp. 3575-3585
    • Arendt, C.S.1    Hochstrasser, M.2
  • 30
    • 0040008534 scopus 로고    scopus 로고
    • Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function
    • Jager S, Groll M, Huber R, Wolf DH, Heinemeyer W, (1999) Proteasome beta-type subunits: unequal roles of propeptides in core particle maturation and a hierarchy of active site function. J Mol Biol 291: 997-1013.
    • (1999) J Mol Biol , vol.291 , pp. 997-1013
    • Jager, S.1    Groll, M.2    Huber, R.3    Wolf, D.H.4    Heinemeyer, W.5
  • 31
    • 50349101943 scopus 로고    scopus 로고
    • Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics
    • Wang L, Kumar S, Fridley BL, Kalari KR, Moon I, et al. (2008) Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics. Clin Cancer Res 14: 3503-3513.
    • (2008) Clin Cancer Res , vol.14 , pp. 3503-3513
    • Wang, L.1    Kumar, S.2    Fridley, B.L.3    Kalari, K.R.4    Moon, I.5
  • 32
    • 33745169658 scopus 로고    scopus 로고
    • Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib
    • Shringarpure R, Catley L, Bhole D, Burger R, Podar K, et al. (2006) Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib. Br J Haematol 134: 145-156.
    • (2006) Br J Haematol , vol.134 , pp. 145-156
    • Shringarpure, R.1    Catley, L.2    Bhole, D.3    Burger, R.4    Podar, K.5
  • 33
    • 0141953292 scopus 로고    scopus 로고
    • Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells
    • Chauhan D, Li G, Shringarpure R, Podar K, Ohtake Y, et al. (2003) Blockade of Hsp27 overcomes Bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res 63: 6174-6177.
    • (2003) Cancer Res , vol.63 , pp. 6174-6177
    • Chauhan, D.1    Li, G.2    Shringarpure, R.3    Podar, K.4    Ohtake, Y.5
  • 34
    • 84055179132 scopus 로고    scopus 로고
    • Results of PX-171-003-A1, An Open-Label, Single-Arm, Phase 2 (Ph 2) Study of Carfilzomib (CFZ) In Patients (pts) with Relapsed and Refractory Multiple Myeloma (MM). ASH 2010
    • Siegel DS, Martin T, Wang M, Vij R, Jakubowiak AJ, et al. (2011) Results of PX-171-003-A1, An Open-Label, Single-Arm, Phase 2 (Ph 2) Study of Carfilzomib (CFZ) In Patients (pts) with Relapsed and Refractory Multiple Myeloma (MM). ASH 2010.
    • (2011)
    • Siegel, D.S.1    Martin, T.2    Wang, M.3    Vij, R.4    Jakubowiak, A.J.5
  • 35
    • 77953937449 scopus 로고    scopus 로고
    • The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo
    • Dasmahapatra G, Lembersky D, Kramer L, Fisher RI, Friedberg J, et al. (2010) The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo. Blood 115: 4478-4487.
    • (2010) Blood , vol.115 , pp. 4478-4487
    • Dasmahapatra, G.1    Lembersky, D.2    Kramer, L.3    Fisher, R.I.4    Friedberg, J.5
  • 36
    • 36148944490 scopus 로고    scopus 로고
    • Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma
    • Kuhn DJ, Chen Q, Voorhees PM, Strader JS, Shenk KD, et al. (2007) Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma. Blood 110: 3281-3290.
    • (2007) Blood , vol.110 , pp. 3281-3290
    • Kuhn, D.J.1    Chen, Q.2    Voorhees, P.M.3    Strader, J.S.4    Shenk, K.D.5
  • 37
    • 0343262654 scopus 로고    scopus 로고
    • Crystal Structure of Epoxomicin:20S Proteasome Reveals a Molecular Basis for Selectivity of a′ b′ - Epoxyketone Proteasome Inhibitors
    • Groll M, Kim KB, Kairies N, Huber R, Crews CM, (2000) Crystal Structure of Epoxomicin:20S Proteasome Reveals a Molecular Basis for Selectivity of a′ b′- Epoxyketone Proteasome Inhibitors. J Am Chem Soc 122: 1237-1238.
    • (2000) J Am Chem Soc , vol.122 , pp. 1237-1238
    • Groll, M.1    Kim, K.B.2    Kairies, N.3    Huber, R.4    Crews, C.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.