Clinicopathological correlations of nestin expression in surgically resectable pancreatic cancer including an analysis of perineural invasion

Journal of Gastrointestinal and Liver Diseases

Volumn 20, Issue 4, 2011, Pages 389-396

  Lenz, Jiri ^a   Karasek, Petr ^b   Jarkovsky, Jiri ^c   Muckova, Katarina ^d   Dite, Petr ^d   Kala, Zdenek ^e   Veselska, Renata ^c   Hermanova, Marketa ^a  

^a ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

^b MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

^c MASARYK UNIVERSITY   (Czech Republic)

^d Department of Pathology ^*  (Czech Republic)

^e UNIVERSITY HOSPITAL BRNO   (Czech Republic)

Author keywords

Nestin; Pancreatic cancer; Perineural invasion; Prognostic factor

Indexed keywords

NESTIN;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER SURGERY; CHRONIC PANCREATITIS; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PANCREAS ADENOCARCINOMA; PERINEURIUM; PROGNOSIS; PROTEIN EXPRESSION;

AGED; CARCINOMA, PANCREATIC DUCTAL; CHI-SQUARE DISTRIBUTION; CZECH REPUBLIC; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; KAPLAN-MEIER ESTIMATE; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NERVE FIBERS; NERVE TISSUE PROTEINS; PANCREATECTOMY; PANCREATIC NEOPLASMS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84055176754     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Saif MW. Pancreatic neoplasm in 2011: an update. JOP 2011;12: 316-321.
2. Hruban RH, Boffetta P, Hiraoka N, et al. Tumours of the pancreas. In: WHO classification of tumours of the digestive system. 4th Edn, Lyon: WHO Press, 2010, 279-338.
3. Wang Z, Li Y, Ahmad A, et al. Pancreatic cancer: understanding and overcoming chemoresistance. Nat Rev Gastroenterol Hepatol 2011; 8: 27-33.
4. Lee MX, Saif MW. Screening for early pancreatic ductal adenocarcinoma: an urgent call! JOP 2009; 10: 104-108.
5. Dunphy EP. Pancreatic cancer: a review and update. Clin J Oncol Nurs 2008;12: 735-741.
6. Hockfield S, McKay RD. Identification of major cell classes in the developing mammalian nervous system. J Neurosci 1985; 5: 3310-3328.
7. Lendahl U, Zimmerman LB, McKay RD. CNS stem cells express a new class of intermediate filament protein. Cell 1990; 60: 585-595.
8. Krum JM, Rosenstein JM. Transient coexpression of nestin, GFAP, and vascular endothelial growth factor in mature reactive astroglia following neural grafting or brain wounds. Exp Neurol 1999;160:348-360.
9. Cízková D, Soukup T, Mokrý J. Nestin expression reflects formation, revascularization and reinnervation of new myofibers in regenerating rat hind limb skeletal muscles. Cells Tissues Organs 2009;189:338-347.
10. Mokrý J, Ehrmann J, Karbanová J, et al. Expression of intermediate filament nestin in blood vessels of neural and non-neural tissues. Acta Medica (Hradec Kralove) 2008; 51:173-179.
11. Ha Y, Choi JU, Yoon DH, Cho YE, Kim TS. Nestin and small heat shock protein expression on reactive astrocytes and endothelial cells in cerebral abscess. Neurosci Res 2002; 44:207-212.
12. Ohike N, Sato M, Hisayuki T, et al. Immunohistochemical analysis of nestin and c-kit and their significance in pancreatic tumors. Pathol Int 2007; 57: 589-593.
13. Ishiwata T, Matsuda Y, Naito Z. Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis. World J Gastroenterol 2011; 17: 409-418.
14. Carrière C, Seeley ES, Goetze T, Longnecker DS, Korc M. The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia. Proc Natl Acad Sci U S A 2007; 104: 4437-4442.
15. Matsuda Y, Naito Z, Kawahara K, Nakazawa N, Korc M, Ishiwata T. Nestin is a novel target for suppressing pancreatic cancer cell migration, invasion and metastasis. Cancer Biol Ther 2011; 11: 512-523.
16. Liu C, Chen B, Zhu J, et al. Clinical implications for nestin protein expression in breast cancer. Cancer Sci 2010; 101: 815-819.
17. Piras F, Perra MT, Murtas D, et al. The stem cell marker nestin predicts poor prognosis in human melanoma. Oncol Rep 2010; 23:17-24.
18. Lonardo E, Hermann PC, Heeschen C. Pancreatic cancer stem cells -update and future perspectives. Mol Oncol 2010; 4:431-442.
19. Cho RW, Clarke MF. Recent advances in cancer stem cells. Curr Opin Genet Dev 2008;18: 48-53.
20. Lee CJ, Dosch J, Simeone DM. Pancreatic cancer stem cells. J Clin Oncol 2008; 26: 2806-2812.
21. Ischenko I, Seeliger H, Kleespies A, et al. Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications. Langenbecks Arch Surg 2010; 395: 1-10.
22. Krupkova O Jr, Loja T, Zambo I, Veselska R. Nestin expression in human tumors and tumor cell lines. Neoplasma 2010; 57: 291-298.
23. Kawamoto M, Ishiwata T, Cho K, et al. Nestin expression correlates with nerve and retroperitoneal tissue invasion in pancreatic cancer. Hum Pathol 2009; 40:189-198.
24. Yang XH, Wu QL, Yu XB, et al. Nestin expression in different tumours and its relevance to malignant grade. J Clin Pathol 2008; 61: 467-473.
25. Veselska R, Kuglik P, Cejpek P, et al. Nestin expression in the cell lines derived from glioblastoma multiforme. BMC Cancer 2006; 6: 32.
26. Zlobec I, Terracciano L, Jass JR, Lugli A. Value of staining intensity in the interpretation of immunohistochemistry for tumor markers in colorectal cancer. Virchows Arch 2007; 451:763-769.
27. Atkins D, Reiffen KA, Tegtmeier CL, Winther H, Bonato MS, Störkel S. Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections. J Histochem Cytochem 2004;52: 893-901.
28. Pour PM, Bell RH, Batra SK. Neural invasion in the staging of pancreatic cancer. Pancreas 2003; 26: 322-325.
29. Ozaki H, Hiraoka T, Mizumoto R, et al. The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection. Surg Today 1999; 29: 16-22.
30. Marchesi F, Piemonti L, Mantovani A, Allavena P. Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis. Cytokine Growth Factor Rev 2010; 21:77-82.
31. Nagakawa T, Kayahara M, Ueno K, et al. A clinicopathologic study on neural invasion in cancer of the pancreatic head. Cancer 1992; 69: 930-935.
32. Liu B, Lu KY. Neural invasion in pancreatic carcinoma. Hepatobiliary Pancreat Dis Int 2002; 1: 469-476.
33. Ceyhan GO, Demir IE, Rauch U, et al. Pancreatic neuropathy results in "neural remodeling" and altered pancreatic innervation in chronic pancreatitis and pancreatic cancer. Am J Gastroenterol 2009;104: 2555-2565.
34. Demir IE, Ceyhan GO, Rauch U, et al. The microenvironment in chronic pancreatitis and pancreatic cancer induces neuronal plasticity. Neurogastroenterol Motil 2010; 22: 480-490, e112-113.
35. Ceyhan GO, Demir IE, Altintas B, et al. Neural invasion in pancreatic cancer: a mutual tropism between neurons and cancer cells. Biochem Biophys Res Commun 2008; 374: 442-447.
36. Ceyhan GO, Schäfer KH, Kerscher AG, et al. Nerve growth factor and artemin are paracrine mediators of pancreatic neuropathy in pancreatic adenocarcinoma. Ann Surg 2010; 251: 923-931.
37. Chédotal A, Kerjan G, Moreau-Fauvarque C. The brain within the tumor: new roles for axon guidance molecules in cancers. Cell Death Differ 2005; 12:1044-1056.
38. Chilton JK. Molecular mechanisms of axon guidance. Dev Biol 2006; 292:13-24.
39. Ceyhan GO, Demir IE, Maak M, Friess H. Fate of nerves in chronic pancreatitis: Neural remodeling and pancreatic neuropathy. Best Pract Res Clin Gastroenterol 2010; 24: 311-322.