Survival in neutropenic Patients with severe sepsis or septic shock

Critical Care Medicine

Volumn 40, Issue 1, 2012, Pages 43-49

  Legrand, Matthieu ^a   Max, Adeline ^a   Peigne, Vincent ^a   Mariotte, Eric ^a   Canet, Emmanuel ^a   Debrumetz, Alexandre ^a   Lemiale, Virginie ^a   Seguin, Amélie ^a   Darmon, Michael ^a   Schlemmer, Benoît ^a   Azoulay, Éilie ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

Diagnosis; Management; Neutropenia; Outcomes; Sepsis; Shock

Indexed keywords

AMINOGLYCOSIDE; BETA LACTAM; CREATININE; HYPERTENSIVE AGENT;

ABDOMINAL INFECTION; ACUTE LEUKEMIA; ADULT; ANTIBIOTIC THERAPY; ARTICLE; BLOODSTREAM INFECTION; CANCER PATIENT; CATHETER INFECTION; CATHETER REMOVAL; CENTRAL NERVOUS SYSTEM INFECTION; CREATININE BLOOD LEVEL; CRITICALLY ILL PATIENT; DISEASE SEVERITY; FEMALE; HOSPITAL ADMISSION; HUMAN; INDWELLING CATHETER; INFECTION; INTENSIVE CARE UNIT; LIVER DYSFUNCTION; LYMPHOMA; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUROLOGIC DISEASE; NEUTROPENIA; OUTCOME ASSESSMENT; PNEUMONIA; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSTATITIS; PYELONEPHRITIS; PYREXIA IDIOPATHICA; RENAL REPLACEMENT THERAPY; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; SENESCENCE; SEPSIS; SEPTIC SHOCK; SKIN INFECTION; SOFT TISSUE INFECTION; SOLID TUMOR; SURGICAL INFECTION; SURVIVAL;

ADULT; AGE FACTORS; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CATHETERS, INDWELLING; FEMALE; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEUTROPENIA; RETROSPECTIVE STUDIES; SEPSIS; SHOCK, SEPTIC;

EID: 84055161223     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31822b50c2     Document Type: Article

References (53)

1. Carlon GC: Admitting cancer patients to the intensive care unit. Crit Care Clin 1988; 4:183-191
2. Bach PB, Schrag D, Nierman DM, et al: Identification of poor prognostic features among patients requiring mechanical ventilation after hematopoietic stem cell transplantation. Blood 2001; 98:3234-3240
3. Blot F, Guiguet M, Nitenberg G, et al: Prognostic factors for neutropenic patients in an intensive care unit: Respective roles of underlying malignancies and acute organ failures. Eur J Cancer 1997; 33:1031-1037
4. Bouchama A, Khan B, Djazmati W, et al: Hematopoietic colony-stimulating factors for neutropenic patients in the ICU. Intensive Care Med 1999; 25:1003-1005
5. Johnson MH, Gordon PW, Fitzgerald FT: Stratification of prognosis in granulocytopenic patients with hematologic malignancies using the APACHE-II severity of illness score. Crit Care Med 1986; 14:693-697
6. Brenner H: Long-term survival rates of cancer patients achieved by the end of the 20th century: A period analysis. Lancet 2002; 360: 1131-1135
7. Darmon M, Azoulay E: Critical care management of cancer patients: Cause for optimism and need for objectivity. Curr Opin Oncol 2009; 21:318-326
8. Benoit DD, Vandewoude KH, Decruyenaere JM, et al: Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication. Crit Care Med 2003; 31:104-112
9. Soares M, Salluh JI, Spector N, et al: Characteristics and outcomes of cancer patients requiring mechanical ventilatory support for +24 hrs. Crit Care Med 2005; 33:520-526
10. Azoulay E, Afessa B: The intensive care support of patients with malignancy: Do everything that can be done. Intensive Care Med 2006; 32:3-5
11. Khassawneh BY, White P Jr, Anaissie EJ, et al: Outcome from mechanical ventilation after autologous peripheral blood stem cell transplantation. Chest 2002; 121:185-188
12. Legriel S, Marijon H, Darmon M, et al: Central neurological complications in critically ill patients with malignancies. Intensive Care Med 2009; 36:232-240
13. Azoulay E, Mokart D, Rabbat A, et al: Diagnostic bronchoscopy in hematology and oncology patients with acute respiratory failure: Prospective multicenter data. Crit Care Med 2008; 36:100-107
14. Hilbert G, Gruson D, Vargas F, et al: Noninvasive ventilation in immunosuppressed patients with pulmonary infiltrates, fever, and acute respiratory failure. N Engl J Med 2001; 344:481-487
15. Bodey GP, Buckley M, Sathe YS, et al: Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 1966; 64:328-340
16. LarchéJ, Azoulay E, Fieux F, et al: Improved survival of critically ill cancer patients with septic shock. Intensive Care Med 2003; 29: 1688-1695
17. Péne F, Percheron S, Lemiale V, et al: Temporal changes in management and outcome of septic shock in patients with malignancies in the intensive care unit. Crit Care Med 2008; 36:690-696
18. Azoulay E, Alberti C, Bornstain C, et al: Improved survival in cancer patients requiring mechanical ventilatory support: Impact of noninvasive mechanical ventilatory support. Crit Care Med 2001; 29:519-525
19. Freifeld AG, Bow EJ, Sepkowitz KA, et al: Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 2011; 52:e56-e93
20. Vincent JL, de Mendonca A, Cantraine F, et al: Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study. Working group on "sepsisrelated problems" of the European Society of Intensive Care Medicine. Crit Care Med 1998; 26:1793-1800
21. Ferreira FL, Bota DP, Bross A, et al: Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001; 286:1754-1758
22. Bone RC, Sibbald WJ, Sprung CL: The ACCPSCCM consensus conference on sepsis and organ failure. Chest 1992; 101:1481-1483
23. Levy MM, Dellinger RP, Townsend SR, et al: The Surviving Sepsis Campaign: Results of an international guideline-based performance improvement program targeting severe sepsis. Crit Care Med 2010; 38:367-374
24. Hughes WT, Armstrong D, Bodey GP, et al: 1997 guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever. Infectious Diseases Society of America. Clin Infect Dis 1997; 25:551-573
25. Mermel LA, Allon M, Bouza E, et al: Clinical practice guidelines for the diagnosis and management of intravascular catheterrelated infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 49:1-45
26. Buchheidt D, Böhme A, Cornely OA, et al: Diagnosis and treatment of documented infections in neutropenic patients-recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol 2003; 82:S127-S132
27. Afessa B, Tefferi A, Hoagland HC, et al: Outcome of recipients of bone marrow transplants who require intensive-care unit support. Mayo Clin Proc 1992; 67:117-122
28. Regazzoni CJ, Irrazabal C, Luna CM, et al: Cancer patients with septic shock: Mortality predictors and neutropenia. Support Care Cancer 2004; 12:833-839
29. Peigne V, Rusinová K, Karlin L, et al: Continued survival gains in recent years among critically ill myeloma patients. Intensive Care Med 2009; 35:512-518
30. Gruson D, Hilbert G, Vargas F, et al: Impact of colony-stimulating factor therapy on clinical outcome and frequency rate of nosocomial infections in intensive care unit neutropenic patients. Crit Care Med 2000; 28:3155-3160
31. Guiguet M, Blot F, Escudier B, et al: Severity-of-illness scores for neutropenic cancer patients in an intensive care unit: Which is the best predictor? Do multiple assessment times improve the predictive value? Crit Care Med 1998; 26:488-493
32. Staudinger T, Stoiser B, Müllner M, et al: Outcome and prognostic factors in critically ill cancer patients admitted to the intensive care unit. Crit Care Med 2000; 28:1322-1328
33. Azoulay E, Darmon M, Delclaux C, et al: Deterioration of previous acute lung injury during neutropenia recovery. Crit Care Med 2002; 30:781-786
34. Darmon M, Azoulay E, Alberti C, et al: Impact of neutropenia duration on short-term mortality in neutropenic critically ill cancer patients. Intensive Care Med 2002; 28: 1775-1780
35. Ferrer R, Artigas A, Suarez D, et al: Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study. Am J Respir Crit Care Med 2009; 180: 861-866
36. Regazzoni CJ, Khoury M, Irrazabal C, et al: Neutropenia and the development of the systemic inflammatory response syndrome. Intensive Care Med 2003; 29:135-138
37. Talcott JA, Finberg R, Mayer RJ, et al: The medical course of cancer patients with fever and neutropenia. Clinical identification of a low-risk subgroup at presentation. Arch Intern Med 1988; 148:2561-2568
38. Azoulay E, Fieux F, Moreau D, et al: Acute monocytic leukemia presenting as acute respiratory failure. Am J Respir Crit Care Med 2003; 167:1329-1333
39. Darmon M, Guichard I, Vincent F, et al: Prognostic significance of acute renal injury in acute tumor lysis syndrome. Leuk Lymphoma 2010; 51:221-227
40. Buyse S, Teixeira L, Galicier L, et al: Critical care management of patients with hemophagocytic lymphohistiocytosis. Intensive Care Med 2010; 36:1695-1702
41. Khorana AA, Francis CW, Culakova E, et al: Thromboembolism in hospitalized neutropenic cancer patients. J Clin Oncol 2006; 24:484-490
42. Afessa B, Tefferi A, Litzow MR, et al: Outcome of diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med 2002; 166:1364-1368
43. Coplin WM, Cochran MS, Levine SR, et al: Stroke after bone marrow transplantation: Frequency, aetiology and outcome. Brain 2001; 124:1043-1051
44. Schiff GD, Hasan O, Kim S, et al: Diagnostic error in medicine: Analysis of 583 physician-reported errors. Arch Intern Med 2009; 169:1881-1887
45. Afessa B, Tefferi A, Litzow MR, et al: Diffuse alveolar hemorrhage in hematopoietic stem cell transplant recipients. Am J Respir Crit Care Med 2002; 166:641-645
46. Lowenthal RM, Eaton K: Toxicity of chemotherapy. Hematol Oncol Clin North Am 1996; 10:967-990
47. Robicsek A, Jacoby GA, Hooper DC: The worldwide emergence of plasmid-mediated quinolone resistance. Lancet Infect Dis 2006; 6:629-440
48. Paul M, Yahav D, Fraser A, et al: Empirical antibiotic monotherapy for febrile neutropenia: Systematic review and meta-analysis of randomized controlled trials. J Antimicrob Chemother 2006; 57:176-189
49. Bartal C, Danon A, Schlaeffer F, et al: Pharmacokinetic dosing of aminoglycosides: A controlled trial. Am J Med 2003; 114:194-198
50. Kumar A, Zarychanski R, Light B, et al: Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis. Crit Care Med 2010; 38:1773-1785
51. Bliziotis IA, Michalopoulos A, Kasiakou SK, et al: Ciprofloxacin vs an aminoglycoside in combination with a beta-lactam for the treatment of febrile neutropenia: A meta-analysis of randomized controlled trials. Mayo Clin Proc 2005; 80:1146-1156
52. Nucci M, Anaissie E, Betts RF, et al: Early removal of central venous catheter in patients with candidemia does not improve outcome: Analysis of 842 patients from 2 randomized clinical trials. Clin Infect Dis 2010; 51:295-303
53. Heffner AC, Horton JM, Marchick MR, et al: Etiology of illness in patients with severe sepsis admitted to the hospital from the emergency department. Clin Infect Dis 2010; 50:814-820