Maternal and sex dependency of insulin resistance: Longitudinal PET and echocardiography study from the healthy fetus to the adult minipig

Journal of Nuclear Medicine

Volumn 52, Issue 12, 2011, Pages 1993-2000

  Guiducci, Letizia ^a   Burchielli, Silvia ^a,b   Chubuchny, Vlad ^a   Sicari, Rosa ^a   Liistro, Tiziana ^a,c   Corciu, Anca I ^a   Pardini, Silvia ^a   Di Cecco, Pietro ^b   Manfredi, Samantha ^a   Bucci, Marco ^a   Salvadori, Piero A ^a   Andreassi, Maria Grazia ^a   Iozzo, Patricia ^a  

^a INSTITUTE OF CLINICAL PHYSIOLOGY   (Italy)

^b FONDAZIONE TOSCANA GABRIELE MONASTERIO   (Italy)

^c SCUOLA SUPERIORE SANT ANNA   (Italy)

Author keywords

DNA damage; Fetal imaging; Myocardial glucose uptake; PET

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE; INSULIN;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR DISEASE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DOPPLER ECHOCARDIOGRAPHY; ECHOCARDIOGRAPHY; FEMALE; FETUS; GLUCOSE METABOLISM; HEART FUNCTION; HEART MUSCLE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESPAN; LIVER; LONGITUDINAL STUDY; MALE; MATERNAL AGE; METABOLIC DISORDER; MINIPIG; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PREGNANCY; PRIORITY JOURNAL; PROGENY; SEX; SEX DIFFERENCE; SKELETAL MUSCLE;

ANIMALS; DNA DAMAGE; FEMALE; FETUS; HEALTH; HEART; INSULIN RESISTANCE; LONGITUDINAL STUDIES; MALE; MOTHERS; ORGAN SPECIFICITY; OXIDATIVE STRESS; POSITRON-EMISSION TOMOGRAPHY; PREGNANCY; SEX CHARACTERISTICS; SWINE; SWINE, MINIATURE; TIME FACTORS; ULTRASONOGRAPHY, PRENATAL;

EID: 83755180757     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.087882     Document Type: Article

References (29)

1. Iozzo P, Chareonthaitawee P, Dutka D, Betteridge DJ, Ferrannini E, Camici PG. Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance. Diabetes. 2002;51:3020-3024.
2. Marinho NV, Keogh BE, Costa DC, Lammerstma AA, Ell PJ, Camici PG. Pathophysiology of chronic left ventricular dysfunction: new insights from the measurement of absolute myocardial blood flow and glucose utilization. Circulation. 1996;93:737-744. (Pubitemid 26052460)
3. Botto N, Masetti S, Petrozzi L, et al. Elevated levels of oxidative DNA damage in patients with coronary artery disease. Coron Artery Dis. 2002;13:269-274. (Pubitemid 35397528)
4. Demirbag R, Yilmaz R, Gur M, et al. DNA damage in metabolic syndrome and its association with antioxidative and oxidative measurements. Int J Clin Pract. 2006;60:1187-1193. (Pubitemid 44363654)
5. Gur M, Yilmaz R, Demirbag R, et al. Lymphocyte DNA damage is associated with increased aortic intima-media thickness. Mutat Res. 2007;617:111-118. (Pubitemid 46386093)
6. Gur M, Yildiz A, Demirbag R, et al. Relationship between left ventricle geometric patterns and lymphocyte DNA damage in patients with untreated essential hypertension. Clin Biochem. 2007;40:454-459. (Pubitemid 46483326)
7. Song F, Jia W, Yao Y, et al. Oxidative stress, antioxidant status and DNA damage in patients with impaired glucose regulation and newly diagnosed type 2 diabetes. Clin Sci (Lond). 2007;112:599-606. (Pubitemid 46849550)
8. Geer EB, Shen W. Gender differences in insulin resistance, body composition, and energy balance. Gend Med. 2009;6(suppl 1):60-75.
9. Mercuro G, Deidda M, Piras A, Dessalvi CC, Maffei S, Rosano GM. Gender determinants of cardiovascular risk factors and diseases. J Cardiovasc Med (Hagerstown). 2010;11:207-220.
10. Wändell PE, Gafvels C. Patients with type 2 diabetes aged 35-64 years at four primary health care centres in Stockholm County, Sweden: prevalence and complications in relation to gender and socio-economic status. Diabetes Res Clin Pract. 2004;63:195-203. (Pubitemid 38142577)
11. Sanchez Moura A, Gomes PF, Mandarim-de-Lacerda CA. Gender determines long-lasting effects on adult offspring heart after early-life malnourishment. Biol Neonate. 2004;85:256-262. (Pubitemid 38813000)
12. Camper-Kirby D, Welch S, Walker A, et al. Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res. 2001;88:1020-1027. (Pubitemid 34137114)
13. Eriksson JG, Forsen T, Tuomilehto J, Winter PD, Osmond C, Barker DJ. Catchup growth in childhood and death from coronary heart disease: longitudinal study. BMJ. 1999;318:427-431. (Pubitemid 29192114)
14. Ong KK, Dunger DB. Birth weight, infant growth and insulin resistance. Eur J Endocrinol. 2004;151(suppl 3):U131-U139. (Pubitemid 39627067)
15. Catalano PM, Presley L, Minium J, Hauguel-de MS. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care. 2009;32:1076-1080.
16. Bartelds B, Gratama JW, Knoester H, et al. Perinatal changes in myocardial supply and flux of fatty acids, carbohydrates, and ketone bodies in lambs. Am J Physiol. 1998;274:H1962-H1969.
17. Bartelds B, Knoester H, Smid GB, et al. Perinatal changes in myocardial metabolism in lambs. Circulation. 2000;102:926-931.
18. 11C-methionine kinetics in pregnant rhesus monkeys studied by positron emission tomography: a new approach to fetomaternal metabolism. Acta Obstet Gynecol Scand. 1984;63:641-645.
19. Benveniste H, Fowler JS, Rooney WD, et al. Maternal-fetal in vivo imaging: a combined PET and MRI study. J Nucl Med. 2003;44:1522-1530. (Pubitemid 39663370)
20. 18F-fluoro-L-thymidine using a pregnant monkey model. J Nucl Med. 2010;51:288-292.
21. 18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study. J Nucl Med. 2006;47:1016-1022.
22. Limesand SW, Rozance PJ, Smith D, Hay WW Jr. Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction. Am J Physiol Endocrinol Metab. 2007;293:E1716-E1725. (Pubitemid 350255124)
23. Bristow J, Rudolph AM, Itskovitz J, Barnes R. Hepatic oxygen and glucose metabolism in the fetal lamb: response to hypoxia. J Clin Invest. 1983;71:1047-1061. (Pubitemid 13098892)
24. Bajpayee M, Dhawan A, Parmar D, Pandey AK, Mathur N, Seth PK. Gender-related differences in basal DNA damage in lymphocytes of a healthy Indian population using the alkaline Comet assay. Mutat Res. 2002;520:83-91. (Pubitemid 35247576)
25. Pansarasa O, Castagna L, Colombi B, Vecchiet J, Felzani G, Marzatico F. Age and sex differences in human skeletal muscle: role of reactive oxygen species. Free Radic Res. 2000;33:287-293.
26. Ren J, Sowers JR, Walsh MF, Brown RA. Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker rats. Am J Physiol Heart Circ Physiol. 2000;279:H1708-H1714.
27. Werner JC, Whitman V, Fripp RR, Schuler HG, Morgan HE. Carbohydrate metabolism in isolated, working newborn pig heart. Am J Physiol. 1981;241:E364-E371.
28. Randall GC. Daily changes in the blood of conscious pigs with catheters in foetal and uterine vessels during late gestation. J Physiol. 1977;270:719-731. (Pubitemid 8170345)
29. Hay WW Jr. Placental-fetal glucose exchange and fetal glucose metabolism. Trans Am Clin Climatol Assoc. 2006;117:321-339.