Gene expression analysis and immunohistochemistry in evaluation of cancer of unknown primary: Time for a patient-centered approach

JNCCN Journal of the National Comprehensive Cancer Network

Volumn 9, Issue 12, 2011, Pages 1415-1420

  Handorf, Charles R ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Gene expression analysis; Immunohistochemistry; STEEEP principles

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADENOCARCINOMA; ARTICLE; AXILLARY LYMPH NODE; BONE METASTASIS; BRAIN METASTASIS; CANCER OF UNKNOWN PRIMARY SITE; CERVICAL LYMPH NODE; CLINICAL DECISION MAKING; FROZEN SECTION; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; LABORATORY DIAGNOSIS; LIVER METASTASIS; LUNG METASTASIS; MEDICAL CARE; PATIENT CARE; PATIENT PREFERENCE; PATIENT SAFETY; PHYSICAL EXAMINATION; PROGNOSIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA;

EID: 83755178031     PISSN: 15401405     EISSN: 15401413     Source Type: Journal    
DOI: 10.6004/jnccn.2011.0120     Document Type: Article

References (22)

1. Institute of Medicine. Crossing the Quality Chasm: a New Health System for the 21st Century. Washington, DC: National Press; 2001.
2. Muir C. Cancer of unknown primary site. Cancer 1995;75:353-356.
3. Pavlidis N, Fizazi K. Cancer of unknown primary (CUP). Crit Rev Oncol Hematol 2005;54:243-250. (Pubitemid 40693686)
4. Marchevsky AM, Gupta R, Balzer B. Diagnosis of metastatic neoplasms: a clinicopathologic and morphologic approach. Arch Pathol Lab Med 2010;134:194-206.
5. Oien KA. Pathologic evaluation of unknown primary cancer. Semin Oncol 2009;36:8-37.
6. Krishna M. Diagnosis of metastatic neoplasms: an immunohistochemical approach. Arch Path Lab Med 2010;134:207-215.
7. Varadhachary GR, Raber MN, Matamoros A, Abbruzzese JL. Carcinoma of unknown primary with a colon-cancer profile-changing paradigm and emerging definitions. Lancet Oncol 2008;9:596-599. (Pubitemid 351722584)
8. Monzon FA, Koen TJ. Diagnosis of metastatic neoplasms: molecular approaches for identification of tissue of origin. Arch Pathol Lab Med 2010;134:216-224.
9. Dumur CI, Lyons-Weiler M, Sciulli C, et al. Interlaboratory performance of a microarray-based gene expression test to determine tissue of origin in poorly differentiated and undifferentiated cancers. J Mol Diagn 2008;10:67-77. (Pubitemid 351184837)
10. Monzon FA, Lyons-Weiler M, Buturovic LJ, et al. Multicenter validation of a 1550-gene expression profile for identification of tumor tissue of origin. J Clin Oncol 2009;27:2503-2508.
11. Pillai R, Deeter R, Rigl CT, et al. Validation of a microarray-based gene expression test for tumors with uncertain origins using formalin-fixed paraffin-embedded (FFPE) specimens [abstract]. J Clin Oncol 2009;27(15S):e22015.
12. Monzon FA, Medeiros F, Lyons-Weiler M, Henner WD. Identification of tissue of origin in carcinoma of unknown primary with a microarray-based gene expression test. Diagn Pathol 2010;5:3.
13. Ma XJ, Patel R, Wang X, et al. Molecular classification of human cancers using a 92-gene real-time quantitative polymerase chain reaction assay. Arch Pathol Lab Med 2006;130:465-473.
14. Rosenwald S, Gilad S, Benjamin S, et al. Validation of micro-RNA based qRT-PCR test for accurate identification of tumor tissue origin. Mod Path 2010;23:814-823.
15. Stancel GA, Coffey D, Alvarez K, et al. Identification of tissue of origin in body fluid specimens using a gene expression microarray assay. Cancer Cytopathol, in press.
16. Pillai R, Deeter R, Rigl CT, et al. Validation and reproducibility of a microarray-based gene expression test for tumor identification in formalin-fixed, paraffin-embedded specimen. J Mol Diagn 2011;13:48-56.
17. Wu AH, Drees JC, Wang H, et al. Gene expression profiles help identify the tissue of origin for metastatic brain cancers. Diagn Pathol 2010;5:26.
18. Grenert JP, Smith A, Ruan W, et al. Gene expression profiling from formalin-fixed, paraffin-embedded tissue for tumor diagnosis. Clin Chim Acta 2011;412:1462-1464.
19. Greco FA, Spigel DR, Yardley DA, et al. Molecular profiling in unknown primary cancer: accuracy of tissue of origin prediction. The Oncologist 2010;15:500-506.
20. McGee RS, Kesty NC, Erlander MG, Schnabel CA. Molecular tumor classification using a 92-gene assay in the differential diagnosis of squamous cell lung cancer. Commun Oncol 2011;7:183-188.
21. Varadhachary GR, Greco FA. Overview of patient management and future directions in unknown primary carcinoma. Semin Oncol 2009;36:75-80.
22. Mueller W, Spector Y, Edmondson T, et al. Accurate classification of metastatic brain tumors using a novel microRNA-based test. The Oncologist 2011;16:165-174.