Cancer's sweet tooth for serine

Breast Cancer Research

Volumn 13, Issue 6, 2011, Pages

  Luo, Ji ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOGLYCERATE DEHYDROGENASE; SERINE;

ARTICLE; BIOSYNTHESIS; BREAST CANCER; CANCER CELL; CELL GROWTH; CELL SURVIVAL; ENZYME BLOOD LEVEL; HUMAN; IN VIVO STUDY; MELANOMA; BREAST TUMOR; ENZYMOLOGY; FEMALE; LETTER; METABOLISM;

BREAST NEOPLASMS; FEMALE; HUMANS; PHOSPHOGLYCERATE DEHYDROGENASE; SERINE;

EID: 83755171652     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2932     Document Type: Article

References (6)

1. Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer 2011, 11:85-95. 10.1038/nrc2981, 21258394.
2. Deberardinis RJ, Sayed N, Ditsworth D, Thompson CB. Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 2008, 18:54-61. 10.1016/j.gde.2008.02.003, 2476215, 18387799.
3. Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature 2011, 476:346-50. 10.1038/nature10350, 21760589.
4. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet 2011, 43:869-74. 10.1038/ng.890, 21804546.
5. de Koning TJ. Treatment with amino acids in serine deficiency disorders. J Inherit Metab Dis 2006, 29:347-351. 10.1007/s10545-006-0269-0, 16763900.
6. Yoshida K, Furuya S, Osuka S, Mitoma J, Shinoda Y, Watanabe M, Azuma N, Tanaka H, Hashikawa T, Itohara S, Hirabayashi Y. Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. J Biol Chem 2004, 279:3573-3577.