Caenorhabditis elegans Δ12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Δ12 and Δ15 positions

Journal of Biological Chemistry

Volumn 286, Issue 51, 2011, Pages 43644-43650

  Zhou, Xue Rong ^a   Green, Allan G ^a   Singh, Surinder P ^a  

^a CSIRO   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIFUNCTIONAL; CAENORHABDITIS ELEGANS; DESATURASE; DESATURATION; DIVERSE RANGE; DOUBLE BONDS; ELEGANS; FATTY ACID CHAINS; FATTY ACID METHYL ESTER; LINOLENIC ACIDS; MASS SPECTROMETRY ANALYSIS; PALMITOLEIC ACID; PHYLOGENETIC ANALYSIS; YEAST CELL;

ELASTICITY; ENZYMES; LINOLEIC ACID; MASS SPECTROMETRY; OLEIC ACID; UNSATURATED FATTY ACIDS; YEAST;

SUBSTRATES;

ACYL COENZYME A DESATURASE; FATTY ACID; FATTY ACID DESATURATASE 2; FATTY ACID ESTER; HEXADECADIENOIC ACID; HEXADECATRIENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; OLEIC ACID; OXAZOLINE DERIVATIVE; PALMITOLEIC ACID; UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; DELTA 12 FATTY ACID DESATURASE; DELTA-12 FATTY ACID DESATURASE; FAT 2 PROTEIN, C ELEGANS; FAT-2 PROTEIN, C ELEGANS; MONOUNSATURATED FATTY ACID; UNSATURATED FATTY ACID;

ARTICLE; CAENORHABDITIS ELEGANS; CHEMICAL BOND; CONTROLLED STUDY; ELASTICITY; ENZYME ACTIVITY; FATTY ACID DESATURATION; FATTY ACID SYNTHESIS; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST CELL; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; GAS CHROMATOGRAPHY; GENE EXPRESSION REGULATION; LIPID METABOLISM; MASS FRAGMENTOGRAPHY; METABOLISM; METHODOLOGY; MOLECULAR CLONING; PROTEIN BINDING;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHROMATOGRAPHY, GAS; CLONING, MOLECULAR; FATTY ACID DESATURASES; FATTY ACIDS; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, UNSATURATED; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION REGULATION; LINOLEIC ACID; LIPID METABOLISM; MODELS, GENETIC; OLEIC ACID; PHYLOGENY; PROTEIN BINDING;

EID: 83755171539     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.266114     Document Type: Article

References (15)

1. Napier, J. A., and Michaelson, L. V. (2001) Lipids 36, 761-766
2. Watts, J. L. (2009) Trends Endocrinol. Metab. 20, 58-65
3. Peyou-Ndi, M. M., Watts, J. L., and Browse, J. (2000) Arch. Biochem. Biophys. 376, 399-408
4. Watts, J. L., and Browse, J. (2002) Proc. Natl. Acad. Sci. U.S.A. 99, 5854-5859
5. Spychalla, J. P., Kinney, A. J., and Browse, J. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 1142-1147
6. Meesapyodsuk, D., Reed, D. W., Savile, C. K., Buist, P. H., Ambrose, S. J., and Covello, P. S. (2000) Biochemistry 39, 11948-11954
7. Damude, H. G., Zhang, H., Farrall, L., Ripp, K. G., Tomb, J. F., Hollerbach, D., and Yadav, N. S. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 9446-9451
8. Hoffmann, M., Hornung, E., Busch, S., Kassner, N., Ternes, P., Braus, G. H., and Feussner, I. (2007) J. Biol. Chem. 282, 26666-26674
9. Sayanova, O., Haslam, R., Guschina, I., Lloyd, D., Christie, W. W., Harwood, J. L., and Napier, J. A. (2006) J. Biol. Chem. 281, 36533-36541
10. Meesapyodsuk, D., Reed, D. W., Covello, P. S., and Qiu, X. (2007) J. Biol. Chem. 282, 20191-20199
11. Mortimer, R. K., and Johnston, J. R. (1986) Genetics 113, 35-43
12. Zhou, X.-R., Robert, S., Singh, S., and Green, A. (2006) Plant Sci. 170, 665-673
13. Fay, L., and Richli, U. (1991) J. Chromatography A 541, 89-98
14. Fellenberg, A. J., Johnson, D. W., Poulos, A., and Sharp, P. (1987) Biomed. Environ. Mass Spectrom. 14, 127-129
15. Pan, Z., Rimando, A. M., Baerson, S. R., Fishbein, M., and Duke, S. O. (2007) J. Biol. Chem. 282, 4326-4335