Nephroprotective activities of the aqueous seed extract of Carica papaya Linn. In carbon tetrachloride induced renal injured wistar rats: A dose- and time-dependent study

Biology and Medicine

Volumn 1, Issue 1, 2009, Pages 11-19

  Olagunju, J A ^a   Adeneye, A A ^a   Fagbohunka, B S ^b   Bisuga, N A ^b   Ketiku, A O ^b   Benebo, A S ^a   Olufowobi, O M ^b   Adeoye, A G ^b   Alimi, M A ^b   Adeleke, A G ^b  

^a LAGOS STATE UNIVERSITY   (Nigeria)

^b Obafemi Awolowo College of Health Sciences   (Nigeria)

Author keywords

Aqueous seed extract; Carbon tetrachloride; Carica papaya Linn.; Nephroprotection; Wistar rats

Indexed keywords

CARICA PAPAYA; RATTUS; RATTUS NORVEGICUS;

EID: 83655212876     PISSN: None     EISSN: 09748369     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Abraham P, Wilfred G, 1999. Oxidative damage to the lipids and proteins of the lungs, testis and kidneys of rats during carbon tetrachloride intoxication. Clin Chim Acta, 289: 177 - 179. doi: 10.1016/S0009-8981(99)00140-0
2. Adelman RD, Spangler WL, Beasom F, Ishizaki G, Conzelman GM, 1981. Frusemide enhancement of neltimicin nephrotoxicity in dogs. The Journal of Antimicrobial Chemotherapy, 7(4): 431 - 440. doi: 10.1093/jac/7.4.431
3. Adeneye AA, Benebo AS, 2008. Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin- and acetaminophen-induced nephrotoxic rats. Journal of Ethnopharmacology, 188: 318-323. doi: 10.1016/j.jep.2008.04.025
4. Adeneye AA, Olagunju JA, In Press. Preliminary hypoglycemic and hypolipidemic activities of the aqueous seed extract of Carica papaya Linn. in Wistar rats. Biology and Medicine.
5. Basu S, 2003. Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients. Toxicology 189: 113 - 127. doi: 10.1016/S0300-483X(03)00157-4
6. Biod T, Sirota B, 1948. In: Watson, A., et al. (Eds.). Practical Clinical Biochemistry. Prentice-Hall of India Private Ltd., New Delhi, India. pp. 142 - 145.
7. Canadian Council of Animal Care, 1984. Guide to the Handling and Use of Experimental Animals. Ottawa, Canada; 2. http://www.ccac.ca/en/CCAC_Programs/Guidelines_Policies/GUIDES/ENGLISH/v2_84/CHXIX_1.HTM
8. Duke JA, 1984. Borderline herbs. CRC Press. Boca raton, Florida, USA.
9. Fadhel ZA, Amran S, 2002. Effects of black tea extract on tetrachloride-induced lipid peroxidation in liver, kidneys and testes of rats. Phytotherapy Research, 16(Supp 1): S28 - S32. doi: 10.1002/ptr.793
10. Gill LS, 1992. Carica papaya L. In: Ethnomedicinal uses of plants in Nigeria. Benin City: UNIBEN Press, pp: 57 - 58. ISBN: 978-2027-20-0
11. Jeong TC, Kim HJ, Park J, Ha CS, Park JD, Kim S, Roh JK, 1996. Protective effects of red ginseng saponins against carbon tetrachlorideinduced hepatotoxicity in Sprague-Dawley rats. Planta Medica, 63: 136 - 140. PMID: 9140227
12. Lu KL, Tsai CC, Ho LK, Lin CC, Chang YS, 2002. Preventive effect of the Taiwan folk medicine Ixeris laevigata var. oldhami on α-naphthyl-isothiocyanate and carbon tetrachloride-induced acute liver injury in rats. Phytotherapy Research, 16: S45 - S50. doi: 10.1002/ptr.801
13. Marsh WH, Fingerhut B, Miller H, 1965. Automated and manual direct methods for the determination of blood urea. Clinical Chemistry, 11(6): 624 - 627. http://www.clinchem.org/cgi/reprint/11/6/624.pdf
14. Miller NJ, Rice-Evans CA, 1997. The relative contribution of ascorbic acid and phenolic antioxidants to the total antioxidant activity of orange and apple fruit juices and blackcurrant drink. Food Chem, 60: 331 - 337. doi: 10.1016/S0308-8146(96)00339-1
15. Ogunyemi CM, Elujoba AA, Durosinmi MA, 2008. Anti-sickling properties of Carica papaya Linn. Journal of Natural Products 1: 56 - 66. http://www.journalofnaturalproducts.com/Volume1/07_JP-Res_Paper-05-2008_s.pdf
16. Olagunju JA, Ogunlana CO, Gbile Z, 1995. Preliminary studies on the hypoglycaemic activity of ethanolic extract of unripe, mature fruits of pawpaw (Carica papaya). Nigerian Journal of Biochemistry and Molecular Biology 10: 21 - 23.
17. Pohl L, Schulick R, George J, 1984. Reductive oxygenation mechanism of metabolism of carbon tetrachloride to phosgene and carbon dioxide formation. Biochemical and Biophysical Research Communication, 25: 318 - 324. doi: 10.1016/0006-291X(83)91209-3
18. Slater TF, 1984. Free radical mechanisms in tissue injury. Biochem J, 222: 1-15. http://www.biochemj.org/bj/222/0001/2220001.pdf
19. Stal P, Olson J, 2000. Ubiquinone: Oxidative stress, and liver carcinogenesis. In: Coenzyme Q: Molecular Mechanisms in Health and Disease, Eds. Kavan VE, Quinn DJ. Boca raton: CRC Press, pp: 317 - 329.
20. Symonik-Lesiuk S, Czechowska G, Stryjecka-Zimmer M, Slomka M, Madro A, Celinski K, Wielosz M, 2003. Catalase, superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication. Journal of Hepatobiliary and Pancreatic Surgery, 10: 309 - 315.doi: 10.1007/S00534-002-0824-5
21. Tom WM, Fong D, Woo B, Prasongwatana V, Boyde TR, 1984. Microsomal lipid peroxidation and oxidative metabolism in rat liver. Chemical and Biological Interactions 50: 361 - 363. doi: 10.1016/0009-2797(84)90043-7