Frequency of tumor entities among liver tumors of unclear etiology initially detected by sonography in the noncirrhotic or cirrhotic livers of 1349 patients: Results of the DEGUM multicenter study

Ultraschall in der Medizin

Volumn 32, Issue 6, 2011, Pages 598-603

  Seitz, K ^a   Greis, C ^a   Schuler, A ^b   Bernatik, T ^e   Blank, W ^c   Dietrich, C F ^d   Strobel, D ^e  

^a KKH Sigmaringen ^*  (Germany)

^b Helfenstein Klinik Geislingen   (Germany)

^c Department of Internal Medicine   (Germany)

^d CARITAS KRANKENHAUS   (Germany)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

CEUS; DEGUM Multicenter Trial; focal liver lesion,; HCC; liver cirrhosis; liver tumor; metastasis; tumor entitiy; ultrasound (US)

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CLINICAL TRIAL; CROSS-SECTIONAL STUDY; DIFFERENTIAL DIAGNOSIS; ECHOGRAPHY; FEMALE; HUMAN; LIVER; LIVER CIRRHOSIS; LIVER DISEASE; LIVER TUMOR; MALE; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CROSS-SECTIONAL STUDIES; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER DISEASES; LIVER NEOPLASMS; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 83655192073     PISSN: 01724614     EISSN: 14388782     Source Type: Journal    
DOI: 10.1055/s-0031-1281858     Document Type: Article

References (49)

1. Strobel D, Seitz K, Blank W et al. Contrast-enhanced Ultrasound for the Characterization of focal Liver Lesions Diagnostic Accuracy in Clinical Practice (DEGUM multicenter trial). Ultraschall in Med: 2008; 29 499 505
2. Strobel D, Seitz K, Blank W et al. Tumor-specific Vascularization Pattern of Liver Metastasis, Hepatocellular Carcinoma, Hemangioma and Focal Nodular Hyperplasia in the Differential Diagnosis of 1349 Liverlesions in Contrast-Enhanced (CEUS). Ultraschall in Med: 2009; 30 376 382
3. Seitz K, Strobel D, Bernatik T et al. Contrast-enhanced Ultrasound (CEUS) for the Characterization of Focal Liver Lesions Prospective Comparison in Clinical Practice: CEUS vs. CT (DEGUM Multicenter Trial). Ultraschall in Med: 2009; 30 383 389
4. Seitz K, Bernatik T, Strobel D et al. Contrast-Enhanced Ultrasound (CEUS) for the Characterization of Focal Liver Lesions in Clinical Practice (DEGUM Multicenter Trial): CEUS vs. MRIa prospective Comparison in 269 Patients. Ultraschall in Med: 2010; 31 1 8
5. Bernatik T, Seitz K, Blank W et al. Unclear Focal Liver Lesions in Contrast-Enhanced Ultrasonography Lessons to be Learned from the DEGUM Multicenter Study for the Characterization of Liver Tumors. Ultraschall in Med: 2010; 31 577 581
6. Mostbeck G. Bildgebende Diagnostik fokaler Leberlsionen: die 90%-Regel. Ultraschall in Med: 2010; 31 545 547
7. Karhunen PJ. Benign hepatic tumours and tumour like conditions in men. J Clin Pathol: 1986; 39 183 188 (Pubitemid 16144974)
8. Oldenburg A, Albrecht T. Sonografische Leberdiagnostik bei Tumorpatienten ohne und mit Kontrastmittel. Ultraschall in Med: 2008; 29 488 498
9. Laghi F, Catalano O, Maresca M et al. Indeterminate, Subcentimetric Focal Liver Lesions in Cancer Patients: Additional Role of Contrast-Enhanced. Ultrasound Ultraschall in Med: 2010; 31 283 288
10. Rode A, Bancel B, Douek P et al. Small nodule detection in cirrhotic livers: evaluation with US, spiral CT, and MRI and correlation with pathologic examination of explanted liver. J Comput Assist Tomogr: 2001; 25 03 327 336 (Pubitemid 32440782)
11. Dodd GD 3rd, Baron RL, Oliver JH 3rd et al. Spectrum of imaging findings of the liver in end-stage cirrhosis: Part II, focal abnormalities. Am J Roentgenol: 1999; 173 05 1185 1192 (Pubitemid 29493987)
12. Mion F, Grozel L, Boillot O et al. Adult cirrhotic liver explants: precancerous lesions and undetected small hepatocellular carcinomas. Gastroenterology: 1996; 111 1587 1592 (Pubitemid 26404223)
13. Gaiani S, Gramantieri L, Venturoli N et al. What is the criterion for differentiating chronic hepatitis from compensated cirrhosis? A prospective study comparing ultrasonography and percutaneous liver biopsy. J Hepatol: 1997; 27 06 979 85 (Pubitemid 27523955)
14. Oberti F, Valsesia E, Pilette C et al. Noninvasive diagnosis of hepatic fibrosis or cirrhosis. Gastroenterology: 1997; 113 05 1609 1616 (Pubitemid 27461247)
15. Wittstock G, Meyer J, Meyer M. The frequency of hepatocellular carcinoma in autopsy material. Zentralbl Allg Pathol: 1988; 134 02 189 196
16. Petry W, Heintges T, Hensel F et al. Hepatocellular carcinoma in Germany. Epidemiology, etiology, clinical aspects and prognosis in 100 consecutive patients of a university clinic. Z Gastroenterol: 1997; 35 1059 1067
17. Kubicka S, Rudolph KL, Hanke M et al. Hepatocellular carcinoma in Germany: a retrospective epidemiological study from a low-endemic area. Liver: 2000; 20 312 318 (Pubitemid 30488002)
18. Ruiz Guinaldo A, Martn Herrera L, Roldn Cuadra R. Hepatic tumors in patients with cirrhosis: an autopsy study. Rev Esp Enferm Dig: 1997; 89 771 780
19. Hamaya K, Hashimoto H, Maeda Y. Metastatic Carcinoma in Cirrhotic Liver a Statistical Survey of Autopsies in Japan. Pathology International: 1975; 25 153 159
20. Pereira-Lima JE, Lichtenfels E, Babosa FS et al. Prevalence study of metastases in cirrhotic livers. Hepatogastroenterology 2003; 50 1490 1495 (Pubitemid 37186517)
21. Melato M, Laurino L, Mucli E et al. Relationship between cirrhosis, liver cancer, and hepatic metastases. An autopsy study. Cancer: 1989; 15 455 459 (Pubitemid 19180409)
22. Seymour K, Charmley RM. Evidence that metastasis is less common in cirrhotic than normal liver: a systematic review of post-mortem case-contol studies. British Journal of surgery: 1999; 86 1237 1242 (Pubitemid 29481527)
23. Vanbockrijck M, Klppel G. Incidence and morphology of liver metastasis from extrahepatic malignancies to cirrhotic livers. Zentralbl Pathol: 1992; 138 91 96
24. MacSween RNM. A clinicopathological review of 100 cases of primary malignant tumours of the liver. J Clin Pathol: 1974; 27 08 669 682
25. Gall EA. Primary and metastatic carcinoma of the liver. Relationship to hepaticcirrhosis. Arch Pathol: 1960; 70 226 232
26. Chomet B, Valaitis J, Pearah G. Metastatic carcinoma in the cirrhotic liver. American J of medical Sciences: 1959; 238 753 759
27. Hanot V, Gilbert A. Etudes sur les Maladie du Foie. Paris Asselin&Houzeau: 1888; I3
28. Poulain A. Cancer de l'estomac. Noyaux secondaires developpes dans un foie cirhotique. Bul Soc anat de Paris: 1898
29. Colwell H. Malignant disease of the liver and bile passages. Arch Middlesex Hosp London: 1905; 5 123 141
30. Lisa JR C, Solomon EJ. Gordon:Secondary carcinoma in cirrhosis of the liver. Amer J Pathol: 1942; 18 137 140
31. Rolleston RD, McNee JW. Diseases of the Liver,Gall-Bladder and Bile Ducts. 3. ed. London Macmillan & Co: 1929
32. Wallach JB, Hyman WA, Angrist A. Metastasis to liver in portal cirrhosis. Amer J clin Pathol: 1953; 23 989 993
33. Seitz G. Why are metatstases in cirrhotic livers so rare? Ultraschall in Med: 1989; 10 123 126 (Pubitemid 19180755)
34. Ruebner BH, Green R, Miayi K et al. The rarity of intrahepatic metastasis in cirrhosis of the liver. Am J Pathol: 1961; 179 537 547
35. Fisher ER, Hellstrom HR, Fisher B. Rarity of Hepatic Metastases in Cirrhosis A Misconception. JAMA: 1960; 174 366 369
36. Seitz G. Metastasierungswege. In: Rettenmaier G, Seitz K. (ed.) Sonographische Differentialdiagnostik, Band 2. 1083 1092
37. Iascone C, Ruperto M, Barillari P. Occurrence of synchronous colorectal cancer metastasis in the cirrhotic or fatty liver. Minerva Chir: 2005; 50 185 190 (Pubitemid 43942493)
38. Song E, Chen J, Ou Q et al. Rare occurrence of metastatic colorectal cancers in livers with replicative hepatitis B infection. Am J Surg: 2001; 181 529 533 (Pubitemid 32769978)
39. Uhlenbruck G, Beuth J, Weidtmann V. Liver lectins: mediators for metastases. Experientia: 1983; 39 1314 1315
40. Uetsuji S, Yamamura M, Yamamichi K et al. Absence of colorectal cancer metastasis to the cirrhotic liver. Am J Surg: 1992; 164 02 176 177
41. Gervaz P, Pak-art R, Nivatvongs S et al. Colorectal adenocarcinoma in cirrhotic patients. J Am Coll Surg: 2003; 196 874 879 (Pubitemid 36676548)
42. Kasper H-U, Drebber U, Dries V et al. Lebermetastasen: Inzidenz und histogenetische Einordnung. Z Gastroenterol: 2005; 43 1149 1157 (Pubitemid 41584817)
43. Brancatelli G, Federle MP, Blachar A et al. Hemangioma in the cirrhotic liver: diagnosis and natural history. Radiology: 2001; 219 01 69 74 (Pubitemid 32234053)
44. Terada T, Kitani S, Ueda K et al. Adenomatous hyperplasia of the liver resembling focal nodular hyperplasia in patients with chronic liver disease. Virchows Arch A Pathol Anat Histopathol: 1993; 422 247 252
45. Quaglia A, Tibballs J, Grasso A et al. Focal nodular hyperplasia-like areas in cirrhosis. Histopathology: 2003; 42 14 21
46. An HJ, Illei P, Diflo T et al. Scirrhous changes in dysplastic nodules do not indicate high-grade status. J Gastroenterol Hepatol: 2003; 18 660 665 (Pubitemid 36791703)
47. Nakashima O, Kurogi M, Yamaguchi R et al. Unique hypervascular nodules in alcoholic liver cirrhosis: identical to focal nodular hyperplasia-like nodules? J Hepatol: 2004; 41 992 998 (Pubitemid 39575667)
48. Lee YH, Kim SH, Cho MY et al. Focal Nodular Hyperplasia-Like Nodules in Alcoholic Liver Cirrhosis: Radiologic-Pathologic Correlation. AJR: 2007; 188
49. Libbrecht L, Cassiman D, Verslype C et al. Clinicopathological Features of Focal Nodular Hyperplasia-Like Nodules in 130 Cirrhotic Explant Livers. The American Journal of Gastroenterology: 2006; 101 2341 2346 (Pubitemid 44477563)