Hepatitis C virus genotyping in Greece: Unexpected high prevalence of genotype 5a in a Greek island

Journal of Medical Virology

Volumn 84, Issue 2, 2012, Pages 223-228

  Karatapanis, Stylianos ^a   Tsoplou, Panagiota ^b   Papastergiou, Vasilios ^a   Vasiageorgi, Aggeliki ^b   Stampori, Maria ^a   Saitis, Ioannis ^b   Tsitsopoulos, Eustathios ^b   Lisgos, Phillipos ^a   Skorda, Lamprini ^c   Ketikoglou, Ioannis ^d   Goulis, Ioannis ^e  

^a General Hospital of Rhodes   (Greece)

^b BIOIATRIKI HEALTHCARE GROUP   (Greece)

^c General Hospital of Chalkida   (Greece)

^d KAT HOSPITAL   (Greece)

^e ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Genotype 5; Greece; Hepatitis C virus; Rhodes

Indexed keywords

PEGINTERFERON; RIBAVIRIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENERAL HOSPITAL; GENOTYPE; GREECE; HEALTH CENTER; HEPATITIS C VIRUS; HUMAN; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; SOUTH AFRICA; VIRUS LOAD;

ADOLESCENT; ADULT; AGED; ANTIVIRAL AGENTS; DRUG THERAPY, COMBINATION; FEMALE; GENOTYPE; GREECE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; LIVER CIRRHOSIS; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; RIBAVIRIN; RNA, VIRAL; VIRAL LOAD; YOUNG ADULT;

EID: 83655180898     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.22249     Document Type: Article

References (22)

1. Antaki N, Haddad M, Kebbewar K, Abdelwahab J, Hamed O, Aaraj R, Alhaj N, Haffar S, Assil M, Ftayeh M, Assaad F, Doghman D, Ali T, Nasserelddine M, Ali A, Antaki F. 2009. The unexpected discovery of a focus of hepatitis C virus genotype 5 in a Syrian province. Epidemiol Infect 137:79-84.
2. Antaki N, Craxi A, Kamal S, Moucari R, Van der Merwe S, Haffar S, Gadano A, Zein N, Lai CL, Pawlotsky JM, Heathcote EJ, Dusheiko G, Marcellin P. 2010. The neglected hepatitis C virus genotypes 4, 5 and 6: An international consensus report. Liver Int 30:342-355.
3. Bernier L, Willems B, Delage G, Murphy DG. 1996. Identification of numerous hepatitis C virus genotypes in Montreal, Canada. J Clin Microbiol 34:2815-2818.
4. Cavalheiro Nde P, De La Rosa A, Elagin S, Tengan FM, Araujo ES, Barone AA. 2009. Hepatitis C: Sexual or intrafamilial transmission? Epidemiological and phylogenetic analysis of hepatitis C virus in 24 infected couples. Rev Soc Bras Med Trop 42:239-244.
5. Chevaliez S, Pawlotsky JM. 2007. Interferon-based therapy of hepatitis C. Adv Drug Deliv Rev 59:1222-1241.
6. Delwaide J, Gerard C, Reenaers C, Vaira D, Bastens B, Bataille C, Servais B, Maes B, Belaiche J, Hepatotropes GL. 2005. Hepatitis C virus genotype 5 in southern belgium: Epidemiological characteristics and response to therapy. Dig Dis Sci 50:2348-2351.
7. Dusheiko G, Schmilovitz-Weiss H, Brown D, McOmish F, Yap PL, Sherlock S, McIntyre N, Simmonds P. 1994. Hepatitis C virus genotypes: An investigation of type-specific differences in geographic origin and disease. Hepatology 19:13-18.
8. Gatselis NK, Rigopoulou E, Stefos A, Kardasi M, Dalekos GN. 2007. Risk factors associated with HCV infection in semi-rural areas of central Greece. Eur J Intern Med 18:48-55.
9. Hadziyannis SJ, Hatzakis A, Papaioannou C, Anastassakos C, Vassiliadis E. 1987. Endemic hepatitis delta virus infection in a Greek community. Prog Clin Biol Res 234:181-202.
10. Henquell C, Cartau C, Abergel A, Laurichesse H, Regagnon C, De Champs C, Bailly JL, Peigue-Lafeuille H. 2004. High prevalence of hepatitis C virus type 5 in central France evidenced by a prospective study from 1996 to 2002. J Clin Microbiol 42:3030-3035.
11. Hnatyszyn HJ. 2005. Chronic hepatitis C and genotyping: The clinical significance of determining HCV genotypes. Antivir Ther 10:1-11.
12. Jover R, Perez-Serra J, de Vera F, Alamo JM, Munoz C, Yago C, Martinez-Ramirez R, Vidal JV. 2001. Infection by genotype 5a of HCV in a district of southeast Spain. Am J Gastroenterol 96:3042-3043.
13. Katsoulidou A, Sypsa V, Tassopoulos NC, Boletis J, Karafoulidou A, Ketikoglou I, Tsantoulas D, Vafiadi I, Hatzis G, Skoutelis A, Akriviadis E, Vasiliadis T, Kitis G, Magiorkinis G, Hatzakis A. 2006. Molecular epidemiology of hepatitis C virus (HCV) in Greece: Temporal trends in HCV genotype-specific incidence and molecular characterization of genotype 4 isolates. J Viral Hepat 13:19-27.
14. Legrand-Abravanel F, Sandres-Saune K, Barange K, Alric L, Moreau J, Desmorat P, Vinel JP, Izopet J. 2004. Hepatitis C virus genotype 5: Epidemiological characteristics and sensitivity to combination therapy with interferon-alpha plus ribavirin. J Infect Dis 189:1397-1400.
15. Levi JE, Takaoka DT, Garrini RH, Fachini RM, Focaccia R, De Bortholi Santos, Mitre E, De Mendonca HP, De Paula JS, Cavalheiro N, Barone AA, Wendel S. 2002. Three cases of infection with hepatitis C virus genotype 5 among Brazilian hepatitis patients. J Clin Microbiol 40:2645-2647.
16. Ohno T, Mizokami M, Tibbs CJ, Ohba K, Suzuki K, Wu RR, Nouri-Aria KT, Williams R. 1994. New genotype of hepatitis C virus in South Africa. J Med Virol 42:409-413.
17. Raptopoulou MTG, Tzourmakliotis G, Nikolopoulou G, Dimopoulou M, Giannoulis G. 2011. Significant epidemiological changes in chronic hepatitis C infection: Results of the nationwide HEPNET-GREECE cohort study. Hippokratia 5:26-31.
18. Robertson B, Myers G, Howard C, Brettin T, Bukh J, Gaschen B, Gojobori T, Maertens G, Mizokami M, Nainan O, Netesov S, Nishioka K, Shin IT, Simmonds P, Smith D, Stuyver L, Weiner A. 1998. Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: Proposals for standardization. International Committee on Virus Taxonomy. Arch Virol 143:2493-2503.
19. Shepard CW, Finelli L, Alter MJ. 2005. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 5:558-567.
20. Simmonds P, Smith DB, McOmish F, Yap PL, Kolberg J, Urdea MS, Holmes EC. 1994. Identification of genotypes of hepatitis C virus by sequence comparisons in the core, E1 and NS-5 regions. J Gen Virol 75:1053-1061.
21. Smuts HE, Kannemeyer J. 1995. Genotyping of hepatitis C virus in South Africa. J Clin Microbiol 33:1679-1681.
22. Verbeeck J, Maes P, Lemey P, Pybus OG, Wollants E, Song E, Nevens F, Fevery J, Delport W, Van der Merwe S, Van Ranst M. 2006. Investigating the origin and spread of hepatitis C virus genotype 5a. J Virol 80:4220-4226.