Efficacy, nephrotoxicity and ototoxicity of aminoglycosides, mathematically modelled for modelling-supported therapeutic drug monitoring

European Journal of Pharmaceutical Sciences

Volumn 45, Issue 1-2, 2012, Pages 90-100

  Croes, Sander ^a   Koop, Arjen H ^b   Van Gils, Stephan A ^b   Neef, Cees ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

Aminoglycosides; Auditory ototoxicity; Efficacy; Modelling; Nephrotoxicity

Indexed keywords

AMINOGLYCOSIDE DERIVATIVE; ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG EFFICACY; DRUG MONITORING; DRUG UPTAKE; HUMAN; KIDNEY CELL; MATHEMATICAL MODEL; NEPHROTOXICITY; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; CELL DEATH; COCHLEA; COCHLEAR DISEASES; COMPUTER SIMULATION; DRUG ADMINISTRATION SCHEDULE; DRUG MONITORING; HAIR CELLS, AUDITORY; HUMANS; KIDNEY; KIDNEY TUBULES; MODELS, BIOLOGICAL; ORGAN OF CORTI; RENAL INSUFFICIENCY; SOFTWARE; TISSUE DISTRIBUTION;

EID: 83655161364     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.10.022     Document Type: Article

References (41)

1. C. Bartal, A. Danon, F. Schlaeffer, K. Reisenberg, M. Alkan, R. Smoliakov, A. Sidi, and Y. Almog Pharmacokinetic dosing of aminoglycosides: a controlled trial Am. J. Med. 114 2003 194 198 (Pubitemid 36294004)
2. R.M. Berne, and M.N. Levy Physiology 5th ed. 2003 Mosby Inc. St. Louis
3. F.O. Black, S. Pesznecker, and V. Stallings Permanent gentamicin vestibulotoxicity Otol. Neurotol. 25 2004 559 569 (Pubitemid 39079780)
4. P.J. Boogaard, G.J. Mulder, and J.F. Nagelkerke Isolated proximal tubular cells from rat kidney as an in vitro model for studies on nephrotoxicity. I. An improved method for preparation of proximal tubular cells and their functional characterization by alpha-methylglucose uptake Toxicol. Appl. Pharmacol. 101 1989 135 143 (Pubitemid 19259043)
5. H.W. Boucher, G.H. Talbot, J.S. Bradley, J.E. Edwards, D. Gilbert, L.B. Rice, M. Scheld, B. Spellberg, and J. Bartlett Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America Clin. Infect. Dis. 48 2009 1 12
6. B.M. Brenner, and F.C. Rector The Kidney 6th ed. 2000 Saunders Philadelphia, PA
7. Carrire, E.G.J., 1980. Gehoorbeschadiging door gentamicine, een klinisch en dierexperimenteel onderzoek. Delft, The Netherlands.
8. Y. Chen, W.G. Huang, D.J. Zha, J.H. Qiu, J.L. Wang, S.H. Sha, and J. Schacht Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinic Hear. Res. 226 2007 178 182 (Pubitemid 46428024)
9. S. Corvaisier, P.H. Maire, M.Y. Bouvier d'Yvoire, X. Barbaut, N. Bleyzac, and R.W. Jelliffe Comparisons between antimicrobial pharmacodynamic indices and bacterial killing as described by using the Zhi model Antimicrob. Agents Chemother. 42 1998 1731 1737 (Pubitemid 28311571)
10. D. Czock, and F. Keller Mechanism-based pharmacokinetic-pharmacodynamic modeling of antimicrobial drug effects J. Pharmacokinet Pharmacodyn. 34 2007 727 751 (Pubitemid 350165274)
11. M.E. De Broe, R.A. Giuliano, and G.A. Verpooten Aminoglycoside nephrotoxicity: mechanism and prevention Adv. Exp. Med. Biol. 252 1989 233 245
12. M.E. De Broe, R.A. Guiliano, and G.A. Verpooten Insights into the renal handling of aminoglycosides: a guideline for prevention of nephrotoxicity J Drug Dev 1 1988 83 92 (Pubitemid 19007412)
13. R.A. Giuliano, G.A. Verpooten, and M.E. De Broe The effect of dosing strategy on kidney cortical accumulation of aminoglycosides in rats Am. J. Kidney Dis. 8 1986 297 303 (Pubitemid 17235073)
14. R.A. Giuliano, G.A. Verpooten, L. Verbist, R.P. Wedeen, and M.E. De Broe In vivo uptake kinetics of aminoglycosides in the kidney cortex of rats J. Pharmacol. Exp. Ther. 236 1986 470 475 (Pubitemid 16184244)
15. A.K. Hurst, K.T. Iseri, M.A. Gill, J.K. Noguchi, T.M. Gilman, and R.W. Jelliffe Comparison of four methods for predicting serum gentamicin concentrations in surgical patients with perforated or gangrenous appendicitis Clin. Pharm. 6 1987 234 238 (Pubitemid 17047232)
16. R.W. Jelliffe, and S.M. Jelliffe Estimation of creatinine clearance from changing serum-creatinine levels Lancet 2 1971 710
17. S.K. Kasiakou, G.J. Sermaides, A. Michalopoulos, E.S. Soteriades, and M.E. Falagas Continuous versus intermittent intravenous administration of antibiotics: a meta-analysis of randomised controlled trials Lancet Infect. Dis. 5 2005 581 589 (Pubitemid 41196757)
18. M.J. Kim, J.S. Bertino Jr., T.A. Erb, P.L. Jenkins, and A.N. Nafziger Application of Bayes theorem to aminoglycoside-associated nephrotoxicity: comparison of extended-interval dosing, individualized pharmacokinetic monitoring, and multiple-daily dosing J. Clin. Pharmacol. 44 2004 696 707 (Pubitemid 38765931)
19. M.G. Koopman, G.C. Koomen, R.T. Krediet, E.A. de Moor, F.J. Hoek, and L. Arisz Circadian rhythm of glomerular filtration rate in normal individuals Clin. Sci. (Lond.) 77 1989 105 111 (Pubitemid 19154032)
20. D.J. Leehey, B.I. Braun, D.A. Tholl, L.S. Chung, C.A. Gross, J.A. Roback, and J.R. Lentino Can pharmacokinetic dosing decrease nephrotoxicity associated with aminoglycoside therapy J. Am. Soc. Nephrol. 4 1993 81 90
21. D. Maglio, C.H. Nightingale, and D.P. Nicolau Extended interval aminoglycoside dosing: from concept to clinic Int. J. Antimicrob. Agents 19 2002 341 348 (Pubitemid 34308980)
22. M.P. Mingeot-Leclercq, and P.M. Tulkens Aminoglycosides: nephrotoxicity Antimicrob. Agents Chemother. 43 1999 1003 1012 (Pubitemid 29214718)
23. J.D. Murray Mathematical Biology 1989 Springer-Verlag Berlin, Heidelberg, New York, London, Paris, Tokyo
24. C. Neef, S.A. van Gils, and W.L. IJzerman Analogy between temperature-dependent and concentration-dependent bacterial killing Comput. Biol. Med. 32 2002 529 549 (Pubitemid 35287140)
25. D.P. Nicolau, C.D. Freeman, P.P. Belliveau, C.H. Nightingale, J.W. Ross, and R. Quintiliani Experience with a once-daily aminoglycoside program administered to 2184 adult patients Antimicrob. Agents Chemother. 39 1995 650 655
26. Prins, J.M., 1995. Antimicrobial therapy of severe Gram-negative infections, dosing of aminoglycoside and studies on endotoxin release. De Meern, The Netherlands.
27. J.M. Prins, H.R. Buller, E.J. Kuijper, R.A. Tange, and P. Speelman Once versus thrice daily gentamicin in patients with serious infections Lancet 341 1993 335 339 (Pubitemid 23039700)
28. F. Rougier, D. Claude, M. Maurin, A. Sedoglavic, M. Ducher, S. Corvaisier, R. Jelliffe, and P. Maire Aminoglycoside nephrotoxicity: modeling, simulation, and control Antimicrob. Agents Chemother. 47 2003 1010 1016 (Pubitemid 36254228)
29. F. Rougier, M. Ducher, M. Maurin, S. Corvaisier, D. Claude, R. Jelliffe, and P. Maire Aminoglycoside dosages and nephrotoxicity: quantitative relationships Clin. Pharmacokinet. 42 2003 493 500 (Pubitemid 36649042)
30. L.P. Rybak Drug ototoxicity Annu. Rev. Pharmacol. Toxicol. 26 1986 79 99 (Pubitemid 16090955)
31. M.J. Rybak, B.J. Abate, S.L. Kang, M.J. Ruffing, S.A. Lerner, and G.L. Drusano Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity Antimicrob. Agents Chemother. 43 1999 1549 1555 (Pubitemid 29331226)
32. J. Schentag Aminoglycoside pharmacokinetics as a guide to therapy and toxicology M.D. Whelton, H.C. Neu, The Aminoglycosides, Microbiology, Clinical Use and Toxicology 1988 Marcel Dekker Inc. New York and Basel 143 167
33. C.J. Van Boxtel, N.H.G. Holford, and M. Danhof The in vivo study of drug action Principles and Applications of Kinetic-Dynamic Modelling 1992 Elsevier
34. G.A. Verpooten, R.A. Giuliano, V.M. Pattyn, S.L. Scharpe, and M.E. De Broe Renal cortical uptake kinetics of gentamicin in rats with impaired renal function Am. J. Kidney Dis. 8 1986 304 307 (Pubitemid 17235074)
35. A.A. Vinks The application of population pharmacokinetic modeling to individualized antibiotic therapy Int. J. Antimicrob. Agents 19 2002 313 322 (Pubitemid 34326393)
36. A.A. Vinks, R.W. Brimicombe, H.G. Heijerman, and W. Bakker Continuous infusion of ceftazidime in cystic fibrosis patients during home treatment: clinical outcome, microbiology and pharmacokinetics J. Antimicrob. Chemother. 40 1997 125 133 (Pubitemid 27341645)
37. M. von Kleist, and W. Huisinga Physiologically based pharmacokinetic modelling: a sub-compartmentalized model of tissue distribution J. Pharmacokinet Pharmacodyn. 34 2007 789 806 (Pubitemid 350165276)
38. A. Watanabe, J. Nagai, Y. Adachi, T. Katsube, Y. Kitahara, T. Murakami, and M. Takano Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists J. Control Release 95 2004 423 433 (Pubitemid 38340493)
39. L. Winston, and N. Benowitz Once-daily dosing of aminoglycosides: how much monitoring is truly required? Am. J. Med. 114 2003 239 240 (Pubitemid 36294014)
40. Zavascki, A.P., 2006. Continuous intravenous administration of antibiotics. Lancet Infect. Dis. 6, 259 [author reply 259-260].
41. J. Zhi, C.H. Nightingale, and R. Quintiliani A pharmacodynamic model for the activity of antibiotics against microorganisms under nonsaturable conditions J. Pharm. Sci. 75 1986 1063 1067 (Pubitemid 17216550)