Neonatal phytoestrogen exposure causes hypospadias in female mice

Molecular Reproduction and Development

Volumn 79, Issue 1, 2012, Pages 3-

  Padilla Banks, Elizabeth ^a   Jefferson, Wendy N ^a   Myers, Page H ^a   Goulding, David R ^a   Williams, Carmen J ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLSTILBESTROL; GENISTEIN;

APOPTOSIS; ARTIFICIAL MILK; FEMALE INFERTILITY; HYPOSPADIAS; LETTER; NONHUMAN; PELVIC ORGAN PROLAPSE; PREGNANCY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; VEGETARIAN DIET;

ANIMALS; ANIMALS, NEWBORN; ENDOCRINE DISRUPTORS; FEMALE; GENISTEIN; HYPOSPADIAS; MALE; MATERNAL EXPOSURE; MICE; PHYTOESTROGENS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; URETHRA; VULVA;

MUS;

EID: 83555177303     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.21395     Document Type: Letter

References (4)

1. Jefferson WN, Williams CJ. 2011. Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes. Reprod Toxicol 31: 272-279.
2. Miyagawa S, Buchanan DL, Sato T, Ohta Y, Nishina Y, Iguchi T. 2002. Characterization of diethylstilbestrol-induced hypospadias in female mice. Anat Rec 266: 43-50.
3. North K, Golding J. 2000. A maternal vegetarian diet in pregnancy is associated with hypospadias. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. BJU Int 85: 107-113.
4. Takasugi N, Bern HA. 1962. Crystals and concretions in the vaginae of persistent-estrous mice. Proc Soc Exp Biol Med 109: 622-624.