Circulating CD8 +CD56 -perforin + T cells are increased in multiple sclerosis patients

Journal of Neuroimmunology

Volumn 240-241, Issue , 2011, Pages 137-141

  Giovanni, Frisullo ^a   Domenico, Plantone ^a   Alessandro, Marti ^a   Raffaele, Iorio ^a   Viviana, Nociti ^a,b   Katia, Patanella Agata ^a,b   Paola, Batocchi Anna ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

Author keywords

CD8 T cells; Disability progression; Multiple sclerosis; Perforin

Indexed keywords

PERFORIN;

ADULT; ARTICLE; CD8+ CD56+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE DURATION; EXPANDED DISABILITY STATUS SCALE; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE;

ADULT; ANTIGENS, CD56; CD8-POSITIVE T-LYMPHOCYTES; DISEASE PROGRESSION; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; PERFORIN; T-LYMPHOCYTE SUBSETS;

EID: 83555176375     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.09.002     Document Type: Article

References (35)

1. Babbe H., Roers A., Waisman A., Lassmann H., Goebels N., Hohlfeld R., Friese M., Schröder R., Deckert M., Schmidt S., Ravid R., Rajewsky K. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J. Exp. Med. 2000, 192(3):393-404.
2. Bjartmar C., Trapp B.D. Axonal degeneration and progressive neurologic disability in multiple sclerosis. Neurotox. Res. 2003, 5(1-2):157-164.
3. Bramow S., Frischer J.M., Lassmann H., Koch-Henriksen N., Lucchinetti C.F., Sørensen P.S., Laursen H. Demyelination versus remyelination in progressive multiple sclerosis. Brain 2010, 133(10):2983-2998.
4. Confavreux C., Vukusic S., Adeleine P. Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process. Brain 2003, 126(Pt 4):770-782.
5. Deb C., Lafrance-Corey R.G., Zoecklein L., Papke L., Rodriguez M., Howe C.L. Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis. J. Neuropathol. Exp. Neurol. 2009, 68(9):1037-1048.
6. Deb C., Lafrance-Corey R.G., Schmalstieg W.F., Sauer B.M., Wang H., German C.L., Windebank A.J., Rodriguez M., Howe C.L. CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis. PLoS One 2010, 5(8):e12478.
7. Friese M.A., Fugger L. Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?. Brain 2005, 128(Pt 8):1747-1763.
8. Friese M.A., Fugger L. Pathogenic CD8(+) T cells in multiple sclerosis. Ann. Neurol. 2009, 66(2):132-141.
9. Frischer J.M., Bramow S., Dal-Bianco A., Lucchinetti C.F., Rauschka H., Schmidbauer M., Laursen H., Sorensen P.S., Lassmann H. The relation between inflammation and neurodegeneration in multiple sclerosis brains. Brain 2009, 132(Pt 5):1175-1189.
10. Frisullo G., Angelucci F., Caggiula M., Nociti V., Iorio R., Patanella A.K., Sancricca C., Mirabella M., Tonali P.A., Batocchi A.P. pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity. J. Neurosci. Res. 2006, 84(5):1027-1036.
11. Göbel K., Melzer N., Herrmann A.M., Schuhmann M.K., Bittner S., Ip C.W., Hünig T., Meuth S.G., Wiendl H. Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack. Glia 2010, 58(4):469-480.
12. Hickey W.F., Hsu B.L., Kimura H. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 1991, 28(2):254-260.
13. Howe C.L., Adelson J.D., Rodriguez M. Absence of perforin expression confers axonal protection despite demyelination. Neurobiol. Dis. 2007, 25(2):354-359.
14. Junker A., Ivanidze J., Malotka J., Eiglmeier I., Lassmann H., Wekerle H., Meinl E., Hohlfeld R., Dornmair K. Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 2007, 130(Pt 11):2789-2799.
15. Kawakami N., Lassmann S., Li Z., Odoardi F., Ritter T., Ziemssen T., Klinkert W.E., Ellwart J.W., Bradl M., Krivacic K., Lassmann H., Ransohoff R.M., Volk H.D., Wekerle H., Linington C., Flügel A. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J. Exp. Med. 2004, 199:185-197.
16. Kremenchutzky M., Rice G.P., Baskerville J., Wingerchuk D.M., Ebers G.C. The natural history of multiple sclerosis: a geographically based study: observations on the progressive phase of the disease. Brain 2006, 129(Pt 3):584-594.
17. Kuhlmann T., Lingfeld G., Bitsch A., Schuchardt J., Brück W. Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain 2002, 125:2202-2212.
18. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983, 33:1444-1452.
19. Leray E., Yaouanq J., Le Page E., et al. Evidence for a two-stage disability progression in multiple sclerosis. Brain 2010, 133(Pt 7):1900-1913.
20. Lowin B., Hahne M., Mattmann C., Tschopp J. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 1994, 370(6491):650-652.
21. Lublin F.D., Baier M., Cutter G. Effect of relapses on development of residual deficit in multiple sclerosis. Neurology 2003, 61(11):1528-1532.
22. Matusevicius D., Kivisäkk P., Navikas V., Söderström M., Fredrikson S., Link H. Interleukin-12 and perforin mRNA expression is augmented in blood mononuclear cells in multiple sclerosis. Scand. J. Immunol. 1998, 47(6):582-590.
23. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., McFarland H.F., Paty D.W., Polman C.H., Reingold S.C., Sandberg-Wollheim M., Sibley W., Thompson A., van den Noort S., Weinshenker B.Y., Wolinsky J.S. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 2001, 50(1):121-127.
24. Melzer N., Meuth S.G., Wiendl H. CD8+ T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability. FASEB J. 2009, 23(11):3659-3673.
25. Miller D.H., Leary S.M. Primary-progressive multiple sclerosis. Lancet Neurol. 2007, 6(10):903-912.
26. Miller D., Barkhof F., Montalban X., Thompson A., Filippi M. Clinically isolated syndromes suggestive of multiple sclerosis, part 2: non-conventional MRI, recovery processes, and management. Lancet Neurol. 2005, 4(6):341-348.
27. Neumann H., Medana I.M., Bauer J., Lassmann H. Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci. 2002, 25(6):313-319.
28. Pirko I., Nolan T.K., Holland S.K., Johnson A.J. Multiple sclerosis: pathogenesis and MR imaging features of T1 hypointensities in murine model. Radiology 2008, 246(3):790-795.
29. Sanchez-Ruiz M., Wilden L., Müller W., Stenzel W., Brunn A., Miletic H., Schlüter D., Deckert M. Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease. J. Immunol. 2008, 180(12):8421-8433.
30. Shresta S., Pham C.T., Thomas D.A., Graubert T.A., Ley T.J. How do cytotoxic lymphocytes kill their targets?. Curr. Opin. Immunol. 1998, 10(5):581-587.
31. Skulina C., Schmidt S., Dornmair K., Babbe H., Roers A., Rajewsky K., Wekerle H., Hohlfeld R., Goebels N. Multiple sclerosis: brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc. Natl. Acad. Sci. U.S.A. 2004, 101(8). 2428-2233.
32. Sobottka B., Harrer M.D., Ziegler U., Fischer K., Wiendl H., Hünig T., Becher B., Goebels N. Collateral bystander damage by myelin-directed CD8+ T cells causes axonal loss. Am. J. Pathol. 2009, 175(3):1160-1166.
33. Trapp B.D., Nave K.A. Multiple sclerosis: an immune or neurodegenerative disorder?. Annu. Rev. Neurosci. 2008, 31:247-269.
34. Wekerle H., Linington C., Lassmann H., Meyermann R. Cellular immune reactivity within the CNS. Trends Neurosci. 1986, 9:271-277.
35. Young P.J., Lederer C., Eder K., Coustans M., Laplaud D., Oger J., Edan G. Relapses and subsequent worsening of disability in relapsing-remitting multiple sclerosis. Neurology 2006, 67(5):804-848.