Estimation of variant Creutzfeldt-Jakob disease infectivity titers in human blood

Transfusion

Volumn 51, Issue 12, 2011, Pages 2596-2602

  Gregori, Luisa ^a,b   Yang, Hong ^a,b   Anderson, Steven ^a,b  

^a Office of Blood Research and Review   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; BOVINE SPONGIFORM ENCEPHALOPATHY AGENT; CREUTZFELDT JAKOB DISEASE; ERYTHROCYTE; ERYTHROCYTE TRANSFUSION; EXPERIMENTAL INFECTION; HUMAN; HUMAN CELL; INFECTION RISK; MAJOR CLINICAL STUDY; NONHUMAN; NONLEUKOREDUCED ERYTHROCYTE; SCRAPIE; UNITED KINGDOM; VIRUS INFECTIVITY; VIRUS TITRATION;

ANIMALS; CATTLE; CREUTZFELDT-JAKOB SYNDROME; ENCEPHALOPATHY, BOVINE SPONGIFORM; FEMALE; HUMANS; MALE; MODELS, THEORETICAL; PRIONS; RODENTIA; SCRAPIE; SHEEP;

EID: 83555174491     PISSN: 00411132     EISSN: 15372995     Source Type: Journal    
DOI: 10.1111/j.1537-2995.2011.03199.x     Document Type: Article

References (28)

1. Lefrère JJ, Hewitt P,. From mad cows to sensible blood transfusion: the risk of prion transmission by labile blood components in the United Kingdom and in France. Transfusion 2009; 49: 797-812.
2. National Creutzfeldt-Jakob Disease Research & Surveillance Unit and UK Blood Services. Transfusion Medicine Epidemiology Review. [cited 2010 Nov 30]. Available from: URL
3. Llewelyn CA, Hewitt PE, Knight RS, Amar K, Cousens S, Mackenzie J, Will RG,. Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion. Lancet 2004; 363: 417-21. (Pubitemid 38210057)
4. Hewitt PE, Llewelyn CA, Mackenzie J, Will RG,. Creutzfeldt-Jakob disease and blood transfusion: results of the UK Transfusion Medicine Epidemiological Review study. Vox Sang 2006; 91: 221-30. (Pubitemid 44337279)
5. UK Health Protection Agency. 2006. New case of transfusion-associated variant-CJD. CDR Wkly, News Archives 9 February 2006, 16 (6). [cited 2010 Nov 30]. Available from: URL
6. UK Health Protection Agency. 2007. Fourth case of transfusion-associated variant-CJD infection. Health Prot Rep, 19 January 2007, 1 (3). [cited 2010 Nov 30]. Available from: URL
7. Peden AH, Head MW, Ritchie DL, Bell JE, Ironside JW,. Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient. Lancet 2004; 364: 527-9. (Pubitemid 39070413)
8. UK Health Protection Agency. vCJD abnormal prion protein found in a patient with haemophilia at post mortem. Press Release, 17 February 2009. [cited 2010 Nov 30]. Available from: URL
9. Peden A, McCardle L, Head MW, Love S, Ward HJ, Cousens SN, Keeling DM, Millar CM, Hill FG, Ironside JW,. Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia. Haemophilia 2010; 16: 296-304.
10. Stramer SL, Hollinger FB, Katz LM, Kleinman S, Metzel PS, Gregory KR, Dodd RY,. Emerging infectious disease agents and their potential threat to transfusion safety. Transfusion 2009; 49 (Suppl 2): 1S-29S.
11. Hunter N, Foster J, Chong A, McCutcheon S, Parnham D, Eaton S, MacKenzie C, Houston F,. Transmission of prion diseases by blood transfusion. J Gen Virol 2002; 83: 2897-905. (Pubitemid 35276989)
12. Houston F, Foster JD, Chong A, Hunter N, Bostock CJ,. Transmission of BSE by blood transfusion in sheep. Lancet 2000; 356: 999-1000.
13. Houston F, McCutcheon S, Goldmann W, Chong A, Foster J, Sisõ S, González L, Jeffrey M, Hunter N,. Prion diseases are efficiently transmitted by blood transfusion in sheep. Blood 2008; 112: 4739-45.
14. Williams L, Brown P, Ironside J, Gibson S, Will R, Ritchie D, Kreil TR, Abee C,. Clinical, neuropathological and immunohistochemical features of sporadic and variant forms of Creutzfeldt-Jakob disease in the squirrel monkey (Saimiri sciureus). J Gen Virol 2007; 88: 688-95. (Pubitemid 46210909)
15. Gregori L, McCombie N, Palmer D, Birch P, Sowemimo-Coker SO, Giulivi A, Rohwer RG,. Effectiveness of leucoreduction for removal of infectivity of transmissible spongiform encephalopathies from blood. Lancet 2004; 364: 529-31. (Pubitemid 39070414)
16. Brown P, Rohwer RG, Dunstan BC, MacAuley C, Gajdusek DC, Drohan WN,. The distribution of infectivity in blood components and plasma derivatives in experimental models of transmissible spongiform encephalopathy. Transfusion 1998; 38: 810-6. (Pubitemid 28421640)
17. Cervenakova L, Yakovleva O, McKenzie C, Kolchinsky S, McShane L, Drohan WN, Brown P,. Similar levels of infectivity in the blood of mice infected with human-derived vCJD and GSS strains of transmissible spongiform encephalopathy. Transfusion 2003; 43: 1687-94. (Pubitemid 37518076)
18. Gregori L, Gurgel PV, Lathrop JT, Edwardson P, Lambert BC, Carbonell RG, Burton SJ, Hammond D, Rohwer RG,. Reduction in infectivity of endogenous transmissible spongiform encephalopathies present in blood by adsorption to selected affinity resins. Lancet 2006; 368: 2232-6.
19. Brown P, Cervenakova L, McShane LM, Barber P, Rubenstein R, Drohan WN,. Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans. Transfusion 1999; 39: 1169-78.
20. Food and Drug Administration. Transmissible Spongiform Encephalopathies Advisory Committee 21st Meeting. June 12, 2009 [cited 2010 Nov 30]. Available from: URL
21. Det Norske Veritas Consulting. Risk of infection from variant CJD in blood. 2004. [cited 2010 Nov 30]. Available from: URL
22. UK Department of Health. Exclusion of blood component recipients from donation: the impact on potential vCJD transmission risks. July 2002 (updated May 2006). [cited 2010 Nov 30]. Available from: URL
23. Gillies M, Chohan G, Llewelyn CA, MacKenzie J, Ward HJ, Hewitt PE, Will RG,. A retrospective case note review of deceased recipients of vCJD-implicated blood transfusions. Vox Sang 2009; 97: 211-8.
24. Davison AC, Hinkley DV,. Bootstrap methods and their application. Cambridge: Cambridge University Press; 1997.
25. Ironside JW, Bishop MT, Connolly K, Hegazy D, Lowrie S, Le Grice M, Ritchie DL, McCardle LM, Hilton DA,. Variant Creutzfeldt-Jakob disease: prion protein genotype analysis of positive appendix tissue samples from a retrospective prevalence study. BMJ 2006; 332: 1186-8. (Pubitemid 44365449)
26. Bishop MT, Hart P, Aitchison L, Baybutt HN, Plinston C, Thomson V, Tuzi NL, Head MW, Ironside JW, Will RG, Manson JC,. Predicting susceptibility and incubation time of human-to-human transmission of vCJD. Lancet Neurol 2006; 5: 393-8.
27. Bishop MT, Pennington C, Heath CA, Will RG, Knight RS,. PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism. BMC Med Genet 2009; 10: 146-55.
28. Dorsey K, Zou S, Schonberger LB, Sullivan M, Kessler D, Notari E 4th, Fang CT, Dodd RY,. Lack of evidence of transfusion transmission of Creutzfeldt-Jakob disease in a US surveillance study. Transfusion 2009; 49: 977-84.