Preparation and characterization of a lovastatin-loaded protein-free nanostructured lipid carrier resembling high-density lipoprotein and evaluation of its targeting to foam cells

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1200-1208

  Gu, Xiao ^a   Zhang, Wenli ^a   Liu, Jianping ^a   Shaw, John P ^b   Shen, Yuanjun ^a   Xu, Yiming ^c   Lu, Hui ^c   Wu, Zimei ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

atherosclerosis; foam cell targeting; high density lipoprotein; lovastatin; nanostructured lipid carrier

Indexed keywords

APOPROTEIN; DRUG VEHICLE; HIGH DENSITY LIPOPROTEIN; MEVINOLIN; NANOSTRUCTURED LIPID CARRIER; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ARTICLE; CRYSTALLIZATION; CYTOTOXICITY; FOAM CELL; HUMAN; MACROPHAGE; MOUSE; NONHUMAN; PARTICLE SIZE; PHAGOCYTOSIS; PRIORITY JOURNAL; ZETA POTENTIAL;

ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHOLESTEROL ESTER TRANSFER PROTEINS; DRUG CARRIERS; DRUG COMPOUNDING; FOAM CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPASE; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; LOVASTATIN; MICE; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; PHAGOCYTOSIS; TECHNOLOGY, PHARMACEUTICAL; TRANSFECTION; U937 CELLS;

EID: 83555168271     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9668-0     Document Type: Article

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