Genetic variation at the 8q24 locus confers risk to multiple myeloma

British Journal of Haematology

Volumn 156, Issue 1, 2012, Pages 133-136

  Tewari, Prerna ^a   Ryan, Anthony W ^a   Hayden, Patrick J ^b   Catherwood, Mark ^c   Drain, Stephen ^c   Staines, Anthony ^d   Grant, Tim ^e   Nieters, Alexandra ^f   Becker, Nikolaus ^f   de Sanjose, Silvia ^g   Foretova, Lenka ^h   Maynardie, Mark ⁱ   Cocco, Pierluigi ^j   Boffetta, Paolo ^k,l   Brennan, Paul ^m   Chanock, Stephen ⁿ   Lawler, Mark ^a   Browne, Paul V ^a,b  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ST JAMES S HOSPITAL   (Ireland)

^c BELFAST CITY HOSPITAL   (United Kingdom)

^d DUBLIN CITY UNIVERSITY   (Ireland)

^e UNIVERSITY COLLEGE DUBLIN   (Ireland)

^f GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^g CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^h MASARYK MEMORIAL CANCER INSTITUTE   (Czech Republic)

ⁱ Registre des Hemopathies Malignes de Cote d'Or   (France)

^j UNIVERSITY OF CAGLIARI   (Italy)

^k MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^l INTERNATIONAL PREVENTION RESEARCH INSTITUTE   (France)

^m INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

ⁿ National Cancer Institute ^*  (United States)

more..

Author keywords

Aetiology; Germline variation; Multiple myeloma; Single nucleotide polymorphisms; Susceptibility

Indexed keywords

DNA;

ALLELE; CANCER RISK; CHROMOSOME 8Q; CHROMOSOME 8Q24; FAM84B GENE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LETTER; MULTIPLE MYELOMA; ONCOGENE MYC; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR GENE;

CHROMOSOMES, HUMAN, PAIR 8; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MULTIPLE MYELOMA; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 83555166135     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08798.x     Document Type: Letter

References (9)

1. Anguiano, A., Tuchman, S.A., Acharya, C., Salter, K., Gasparetto, C., Zhan, F., Dhodapkar, M., Nevins, J., Barlogie, B., Shaughnessy, Jr, J.D. & Potti, A. (2009) Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma. Journal of Clinical Oncology, 27, 4197-4203.
2. Easton, D.F., Pooley, K.A., Dunning, A.M., Pharoah, P.D., Thompson, D., Ballinger, D.G., Struewing, J.P., Morrison, J., Field, H., Luben, R., Wareham, N., Ahmed, S., Healey, C.S., Bowman, R., Meyer, K.B., Haiman, C.A., Kolonel, L.K., Henderson, B.E., Le Marchand, L., Brennan, P., Sangrajrang, S., Gaborieau, V., Odefrey, F., Shen, C.Y., Wu, P.E., Wang, H.C., Eccles, D., Evans, D.G., Peto, J., Fletcher, O., Johnson, N., Seal, S., Stratton, M.R., Rahman, N., Chenevix-Trench, G., Bojesen, S.E., Nordestgaard, B.G., Axelsson, C.K., Garcia-Closas, M., Brinton, L., Chanock, S., Lissowska, J., Peplonska, B., Nevanlinna, H., Fagerholm, R., Eerola, H., Kang, D., Yoo, K.Y., Noh, D.Y., Ahn, S.H., Hunter, D.J., Hankinson, S.E., Cox, D.G., Hall, P., Wedren, S., Liu, J., Low, Y.L., Bogdanova, N., Schurmann, P., Dork, T., Tollenaar, R.A., Jacobi, C.E., Devilee, P., Klijn, J.G., Sigurdson, A.J., Doody, M.M., Alexander, B.H., Zhang, J., Cox, A., Brock, I.W., MacPherson, G., Reed, M.W., Couch, F.J., Goode, E.L., Olson, J.E., Meijers-Heijboer, H., van den Ouweland, A., Uitterlinden, A., Rivadeneira, F., Milne, R.L., Ribas, G., Gonzalez-Neira, A., Benitez, J., Hopper, J.L., McCredie, M., Southey, M., Giles, G.G., Schroen, C., Justenhoven, C., Brauch, H., Hamann, U., Ko, Y.D., Spurdle, A.B., Beesley, J., Chen, X., Mannermaa, A., Kosma, V.M., Kataja, V., Hartikainen, J., Day, N.E., Cox, D.R. & Ponder, B.A. (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447, 1087-1093.
3. Ghoussaini, M., Song, H., Koessler, T., Al Olama, A.A., Kote-Jarai, Z., Driver, K.E., Pooley, K.A., Ramus, S.J., Kjaer, S.K., Hogdall, E., DiCioccio, R.A., Whittemore, A.S., Gayther, S.A., Giles, G.G., Guy, M., Edwards, S.M., Morrison, J., Donovan, J.L., Hamdy, F.C., Dearnaley, D.P., Ardern-Jones, A.T., Hall, A.L., O'Brien, L.T., Gehr-Swain, B.N., Wilkinson, R.A., Brown, P.M., Hopper, J.L., Neal, D.E., Pharoah, P.D., Ponder, B.A., Eeles, R.A., Easton, D.F. & Dunning, A.M. (2008) Multiple loci with different cancer specificities within the 8q24 gene desert. Journal of the National Cancer Institute, 100, 962-966.
4. Gudmundsson, J., Sulem, P., Manolescu, A., Amundadottir, L.T., Gudbjartsson, D., Helgason, A., Rafnar, T., Bergthorsson, J.T., Agnarsson, B.A., Baker, A., Sigurdsson, A., Benediktsdottir, K.R., Jakobsdottir, M., Xu, J., Blondal, T., Kostic, J., Sun, J., Ghosh, S., Stacey, S.N., Mouy, M., Saemundsdottir, J., Backman, V.M., Kristjansson, K., Tres, A., Partin, A.W., Albers-Akkers, M.T., Godino-Ivan Marcos, J., Walsh, P.C., Swinkels, D.W., Navarrete, S., Isaacs, S.D., Aben, K.K., Graif, T., Cashy, J., Ruiz-Echarri, M., Wiley, K.E., Suarez, B.K., Witjes, J.A., Frigge, M., Ober, C., Jonsson, E., Einarsson, G.V., Mayordomo, J.I., Kiemeney, L.A., Isaacs, W.B., Catalona, W.J., Barkardottir, R.B., Gulcher, J.R., Thorsteinsdottir, U., Kong, A. & Stefansson, K. (2007) Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nature Genetics, 39, 631-637.
5. Haiman, C.A., Patterson, N., Freedman, M.L., Myers, S.R., Pike, M.C., Waliszewska, A., Neubauer, J., Tandon, A., Schirmer, C., McDonald, G.J., Greenway, S.C., Stram, D.O., Le Marchand, L., Kolonel, L.N., Frasco, M., Wong, D., Pooler, L.C., Ardlie, K., Oakley-Girvan, I., Whittemore, A.S., Cooney, K.A., John, E.M., Ingles, S.A., Altshuler, D., Henderson, B.E. & Reich, D. (2007) Multiple regions within 8q24 independently affect risk for prostate cancer. Nature Genetics, 39, 638-644.
6. Landgren, O. & Weiss, B.M. (2009) Patterns of monoclonal gammopathy of undetermined significance and multiple myeloma in various ethnic/racial groups: support for genetic factors in pathogenesis. Leukemia, 23, 1691-1697.
7. Park, S.L., Chang, S.C., Cai, L., Cordon-Cardo, C., Ding, B.G., Greenland, S., Hussain, S.K., Jiang, Q., Liu, S., Lu, M.L., Mao, J.T., Morgenstern, H., Mu, L.N., Ng, L.J., Pantuck, A., Rao, J., Reuter, V.E., Tashkin, D.P., You, N.C., Yu, C.Q., Yu, S.Z., Zhao, J.K., Belldegrun, A. & Zhang, Z.F. (2008) Associations between variants of the 8q24 chromosome and nine smoking-related cancer sites. Cancer Epidemiology Biomarkers and Prevention, 17, 3193-3202.
8. Tomlinson, I., Webb, E., Carvajal-Carmona, L., Broderick, P., Kemp, Z., Spain, S., Penegar, S., Chandler, I., Gorman, M., Wood, W., Barclay, E., Lubbe, S., Martin, L., Sellick, G., Jaeger, E., Hubner, R., Wild, R., Rowan, A., Fielding, S., Howarth, K., Silver, A., Atkin, W., Muir, K., Logan, R., Kerr, D., Johnstone, E., Sieber, O., Gray, R., Thomas, H., Peto, J., Cazier, J.B. & Houlston, R. (2007) A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nature Genetics, 39, 984-988.
9. Wokolorczyk, D., Gliniewicz, B., Sikorski, A., Zlowocka, E., Masojc, B., Debniak, T., Matyjasik, J., Mierzejewski, M., Medrek, K., Oszutowska, D., Suchy, J., Gronwald, J., Teodorczyk, U., Huzarski, T., Byrski, T., Jakubowska, A., Gorski, B., van de Wetering, T., Walczak, S., Narod, S.A., Lubinski, J. & Cybulski, C. (2008) A range of cancers is associated with the rs6983267 marker on chromosome 8. Cancer Research, 68, 9982-9986.