Switching from oxycodone to methadone in advanced cancer patients

Supportive Care in Cancer

Volumn 20, Issue 1, 2012, Pages 191-194

  Mercadante, Sebastiano ^a,b   Ferrera, Patrizia ^a   Villari, Patrizia ^a   Adile, Claudio ^a   Casuccio, Alessandra ^b  

^a LA MADDALENA CANCER CENTER   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Conversion ratio; Methadone; Opioid switching; Oxycodone

Indexed keywords

METHADONE; OPIATE; OXYCODONE;

ADVANCED CANCER; ADVERSE OUTCOME; AGED; ANALGESIA; ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; HUMAN; LUNG CANCER; MALE; OUTCOME ASSESSMENT; PAIN; PAIN ASSESSMENT; PALLIATIVE THERAPY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE CANCER; UNSPECIFIED SIDE EFFECT;

AGED; ANALGESICS, OPIOID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; METHADONE; MIDDLE AGED; NEOPLASMS; OXYCODONE; PAIN; PALLIATIVE CARE; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 83555164803     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-011-1259-9     Document Type: Article

References (16)

1. Bercovitch M, Adunsky A (2006) High dose controlled-release oxycodone in hospice care. J Pain Palliat Care Pharm 20:33-39 (Pubitemid 46018090)
2. Bruera E, Pereira J, Watanabe S et al (1996) Opioid rotation in patients with cancer pain. A retrospective comparison of dose ratios between methadone, hydromorphone, and morphine. Cancer 78:852-857 (Pubitemid 26268617)
3. Expert Working Group of the European Association of Palliative Care Network, Cherny N, Ripamonti C, Pereira J, Davis C, Fallon M, McQuay H, Mercadante S, Pasternak G, Ventafridda V (2001) Strategies to manage the adverse effects of oral morphine: an evidence-based report. J Clin Oncol 19:2542-2554 (Pubitemid 32391226)
4. Fine PG, Portenoy RK (2009) Establishing best practices for opioid rotation: conclusions of an expert panel. J Pain Symptom Manage 38:418-425
5. Knotkova H, Fine P, Portenoy RK (2009) Opioid rotation: the science and the limitations of the equianalgesic dose table. J Pain Symptom Manage 38:426-439
6. Lawlor P, Turner K, Hanson J, Bruera E (1998) Dose ratio between morphine and methadone in patients with cancer pain: a retrospective study. Cancer 82:1167-1173 (Pubitemid 28136533)
7. Mercadante S, Ferrera P, David F, Casuccio A (2011) The use of high doses of oxycodone in an acute palliative care unit. Am J Hosp Pall Care 28:242-244
8. Mercadante S, Bruera E (2006) Opioid switching: a systematic and critical review. Cancer Treat Rev 32:304-315 (Pubitemid 44502005)
9. Mercadante S, Ferrera P, Villari P, Casuccio A, Intravaia G, Mangione S (2009) Frequency, indications, outcomes, and predictive factors of opioid switching in an acute palliative care unit. J Pain Symptom Manage 37:632-641
10. Mercadante S, Casuccio A, Calderone L (1999) Rapid switching from morphine to methadone in cancer patients with poor response to morphine. J Clin Oncol 17:3307-3312 (Pubitemid 29470667)
11. Reid CM, Martin RM, Sterne JA, Davies AN, Hanks GW (2006) Oxycodone for cancer-related pain: meta-analysis of randomized controlled trials. Arch Intern Med 166:837-843
12. Riley J, Ross JR, Rutter D, Wells AU, Goller K, du Bois R, Welsh K (2006) No pain relief from morphine? Individual variation in sensitivity to morphine and the need to switch to an alternative opioid in cancer patients. Support Care Cancer 14:56-64 (Pubitemid 43119598)
13. Ripamonti C, Groff L, Brunelli C et al (1998) Switching from morphine to oral methadone in treating cancer pain: what is the equianalgesic dose ratio? J Clin Oncol 16:3216-3221 (Pubitemid 28481614)
14. Silvestri B, Bandieri E, Del prete S et al (2008) Oxycodone controlled-release as first choice therapy for moderate-to-severe cancer pain in Italian patients. Clin Drug Invest 28:399-407
15. Slatkin N (2009) Opioid switching and rotation in primary care: implementation and clinical utility. Curr Med Res Opin 25:2133-2159
16. Weschules D, Bain K (2008) A systematic review of opioid conversion ratios used with methadone for the treatment of pain. Pain Med 9:595-612