Gene-viro-therapy targeting liver cancer by a dual-regulated oncolytic adenoviral vector harboring IL-24 and TRAIL

Cancer Gene Therapy

Volumn 19, Issue 1, 2012, Pages 49-57

  Liu, X ^a,b   Cao, X ^b   Wei, R ^b   Cai, Y ^b   Li, H ^b   Gui, J ^b   Zhong, D ^b   Liu, X Y ^b   Huang, K ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

apoptosis; cancer targeting gene viro therapy; interleukin 24; liver cancer; tumor necrosis factor related apoptosis inducing ligand

Indexed keywords

ALPHA FETOPROTEIN; CASPASE 8; CASPASE 9; E1A PROTEIN; INTERLEUKIN 24; ONCOLYTIC ADENOVIRUS; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CONTROLLED STUDY; DISEASE MODEL; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL CARCINOMA; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SURVIVAL RATE; VIRAL GENE THERAPY; XENOGRAFT;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; FEMALE; GENE THERAPY; GENETIC VECTORS; HUMANS; INTERLEUKINS; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; ONCOLYTIC VIROTHERAPY; ONCOLYTIC VIRUSES; TNF-RELATED APOPTOSIS-INDUCING LIGAND; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA; MUS;

EID: 83555161695     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2011.67     Document Type: Article

References (23)

1. Liu XY. A new anticancer strategy-gene-viroTherapy Therapy of cancer. Chinese J Cancer Biother 2001; 8: 1.
2. Pei Z, Chu L, Zou W, Zhang Z, Qiu S, Qi R et al. An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice. Hepatology 2004; 39: 1371-1381. (Pubitemid 38569059)
3. Zhao L, Dong A, Gu J, Liu Z, Zhang Y, Zhang W et al. The antitumor activity of TRAIL and IL-24 with replicating oncolytic adenovirus in colorectal cancer. Cancer Gene Ther 2006; 13: 1011-1022. (Pubitemid 44564737)
4. Zhang Y, Gu J, Zhao L, He L, Qian W, Wang J et al. Complete elimination of colorectal tumor xenograft by combined manganese superoxide dismutase with tumor necrosis factor-related apoptosis-inducing ligand gene virotherapy. Cancer Res 2006; 66: 4291-4298.
5. Liu XY, Qiu SB, Zou WG, Pei ZF, Gu JF, Luo CX et al. Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5. Mol Ther 2005; 11: 531-541.
6. Fisher PB. Is mda-7/IL-24 a 'magic bullet' for cancer? Cancer Res 2005; 65: 10128-10138.
7. Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995; 3: 673-682. (Pubitemid 26091143)
8. Kagawa S, He C, Gu J, Koch P, Rha SJ, Roth JA et al. Antitumor activity and bystander effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene. Cancer Res 2001; 61: 3330-3338. (Pubitemid 32695022)
9. Shi J, Zheng D, Liu Y, Sham MH, Tam P, Farzaneh F et al. Overexpression of soluble TRAIL induces apoptosis in human lung adenocarcinoma and inhibits growth of tumor xenografts in nude mice. Cancer Res 2005; 65: 1687-1692. (Pubitemid 40478593)
10. Cao X, Yang M, Wei RC, Zeng Y, Gu JF, Huang WD et al. Cancer targeting gene-viro-therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene. Gene Therapy 2011; 18: 765-777.
11. Zhang ZL, Zou WG, Luo CX, Li BH, Wang JH, Sun LY et al. An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy. Cell Res 2003; 13: 481-489. (Pubitemid 43231842)
12. Bischoff JR, Kirn DH, Williams A, Heise C, Horn S, Muna M et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 1996; 274: 373-376. (Pubitemid 26353341)
13. Wei N, Fan JK, Gu JF, He LF, Tang WH, Cao X et al. A double-regulated oncolytic adenovirus with improved safety for adenocarcinoma therapy. Biochem Biophys Res Commun 2009; 388: 234-239.
14. Camper SA, Tilghman SM. The activation and silencing of gene transcription in the liver. Biotechnology 1991; 16: 81-87.
15. Nakabayashi H, Hashimoto T, Miyao Y, Tjong KK, Chan J, Tamaoki T. A position-dependent silencer plays a major role in repressing alpha-fetoprotein expression in human hepatoma. Mol Cell Biol 1991; 11: 5885-5893. (Pubitemid 21895356)
16. Herrmann M, Lorenz HM, Voll R, Grunke M, Woith W, Kalden JR. A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res 1994; 22: 5506-5507.
17. Takahashi M, Sato T, Sagawa T, Lu Y, Sato Y, Iyama S et al. E1B-55K-deleted adenovirus expressing E1A-13S by AFP-enhancer/promoter is capable of highly specific replication in AFP-producing hepatocellular carcinoma and eradication of established tumor. Mol Ther 2002; 5: 627-634. (Pubitemid 34546093)
18. Kim J, Lee B, Kim JS, Yun CO, Kim JH, Lee YJ et al. Antitumoral effects of recombinant adenovirus YKL-1001, conditionally replicating in alpha-fetoprotein-producing human liver cancer cells. Cancer Lett 2002; 180: 23-32. (Pubitemid 34242960)
19. Zhang J, Gan Y, Gu J, Hu J, Liu X, Zhao X. Potent antihepatoma efficacy of HCCS1 via dual tumor-targeting genevirotherapy strategy. Oncol Rep 2008; 20: 1035-1040.
20. Liu XR, Cai Y, Cao X, Wei RC, Li HL, Zhou XM et al. A new oncolytic adenoviral vector carrying dual tumor suppressor genes shows potent antitumor effect. J Cell Mol Med 2011 (in press).
21. Saeki T, Mhashilkar A, Swanson X, Zou-Yang XH, Sieger K, Kawabe S et al. Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo. Oncogene 2002; 21: 4558-4566. (Pubitemid 34785732)
22. Soria C, Estermann FE, Espantman KC, O'Shea CC. Heterochromatin silencing of p53 target genes by a small viral protein. Nature 2010; 466: 1076-1081.
23. Cui Q, Jiang W, Wang Y, Lv C, Luo J, Zhang W et al. Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Hepatology 2008; 47: 105-112. (Pubitemid 351171047)