The atypical thyroid fine-needle aspiration: Past, present, and future

Cancer Cytopathology

Volumn 120, Issue 2, 2012, Pages 73-86

  Bongiovanni, Massimo ^a   Krane, Jeffrey F ^b   Cibas, Edmund S ^b   Faquin, William C ^c  

^a INSTITUTE OF PATHOLOGY   (Switzerland)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Atypia; Atypia of undetermined significance follicular lesion of undetermined significance (AUS FLUS); Bethesda; Fine needle aspiration; Thyroid

Indexed keywords

CANCER CLASSIFICATION; CANCER RISK; CYTOARCHITECTURE; CYTOPATHOLOGY; FINE NEEDLE ASPIRATION BIOPSY; HUMAN; MICROMORPHOLOGY; PRIORITY JOURNAL; REVIEW; THYROID CARCINOMA; CLASSIFICATION; NEEDLE BIOPSY; PATHOLOGY; THYROID TUMOR;

BIOPSY, FINE-NEEDLE; HUMANS; THYROID NEOPLASMS;

EID: 83455259171     PISSN: None     EISSN: 19346638     Source Type: Journal    
DOI: 10.1002/cncy.20178     Document Type: Review

References (58)

1. Gharib H, Goellner Jr. Fine-needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med. 1993;118:282-289.
2. Cibas ES, Ali SZ; NCI Thyroid FNA State of the Science Conference. The Bethesda System For Reporting Thyroid Cytopathology. Am J Clin Pathol. 2009;132:658-665.
3. Krane JF, Nayar R, Renshaw AA. Atypical cells of undetermined significance. In: Ali SZ, Cibas ES, eds. The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria and Explanatory Notes. New York: Springer; 2010:37-49.
4. Redman R, Yoder BJ, Massoll NA. Perceptions of diagnostic terminology and cytopathologic reporting of fine-needle aspiration biopsies of thyroid nodules: a survey of clinicians and pathologists. Thyroid. 2006;16:1003-1008.
5. Yoder BJ, Redman R, Massoll NA. Validation of a five-tier cytodiagnostic system for thyroid fine needle aspiration biopsies using cytohistologic correlation. Thyroid. 2006;16: 781-786.
6. Poller DN, Ibrahim AK, Cummings MH, Mikel JJ, Boote D, Perry M. Fine-needle aspiration of the thyroid. Cancer. 2000;90:239-244.
7. Rabaglia JL, Kabbani W, Wallace L, et al. Effect of the Bethesda system for reporting thyroid cytopathology on thyroidectomy rates and malignancy risk in cytologically indeterminate lesions. Surgery. 2010;148:1267-1272; discussion 1272-1273.
8. Pang T, Ihre-Lundgren C, Gill A, et al. Correlation between indeterminate aspiration cytology and final histopathology of thyroid neoplasms. Surgery. 2010;148:532-537.
9. Marhefka GD, McDivitt JD, Shakir KM, Drake AJ 3rd. Diagnosis of follicular neoplasm in thyroid nodules by fine needle aspiration cytology: does the result, benign vs. suspicious for a malignant process, in these nodules make a difference? Acta Cytol. 2009;53:517-523.
10. Miller B, Burkey S, Lindberg G, Snyder WH 3rd, Nwariaku FE. Prevalence of malignancy within cytologically indeterminate thyroid nodules. Am J Surg. 2004; 188:459-462.
11. Abele JS, Levine RA. Diagnostic criteria and risk-adapted approach to indeterminate thyroid cytodiagnosis. Cancer (Cancer Cytopathol). 2010;118:415-422.
12. Ali SZ, Cibas ES, eds. The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria and Explanatory Notes. New York: Springer; 2010.
13. Lewis CM, Chang KP, Pitman M, Faquin WC, Randolph GW. Thyroid fine-needle aspiration biopsy: variability in reporting. Thyroid. 2009;19:717-723.
14. Baloch ZW, LiVolsi VA, Asa SL, et al. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol. 2008;36:425-437.
15. Layfield LJ, Morton MJ, Cramer HM, Hirschowitz S. Implications of the proposed thyroid fine-needle aspiration category of ''follicular lesion of undetermined significance'': a five-year multi-institutional analysis. Diagn Cytopathol. 2009;37:710-714.
16. Ohori NP, Nikiforova MN, Schoedel KE, et al. Contribution of molecular testing to thyroid fine-needle aspiration cytology of ''follicular lesion of undetermined significance/atypia of undetermined significance.'' Cancer (Cancer Cytopathol). 2010;118:17-23.
17. Nayar R, Ivanovic M. The indeterminate thyroid fine-needle aspiration: experience from an academic center using terminology similar to that proposed in the 2007 National Cancer Institute Thyroid Fine Needle Aspiration State of the Science Conference. Cancer (Cancer Cytopathol). 2009;117:195-202.
18. VanderLaan PA, Marqusee E, Krane JF. Clinical outcome for atypia of undetermined significance in thyroid fine-needle aspirations: should repeated fna be the preferred initial approach? Am J Clin Pathol. 2011;135:770-775.
19. Faquin WC, Baloch ZW. Fine-needle aspiration of follicular patterned lesions of the thyroid: diagnosis, management, and follow-up according to National Cancer Institute (NCI) recommendations. Diagn Cytopathol. 2010;38: 731-739.
20. Renshaw AA. Should ''atypical follicular cells'' in thyroid fine-needle aspirates be subclassified? Cancer (Cancer Cytopathol). 2010;118:186-189.
21. Theoharis CG, Schofield KM, Hammers L, Udelsman R, Chhieng DC. The Bethesda thyroid fine-needle aspiration classification system: year 1 at an academic institution. Thyroid. 2009;19:1215-1223.
22. Jo VY, Stelow EB, Dustin SM, Hanley KZ. Malignancy risk for fine-needle aspiration of thyroid lesions according to the Bethesda System for Reporting Thyroid Cytopathology. Am J Clin Pathol. 2010;134:450-456.
23. Giorgadze T, Rossi ED, Fadda G, Gupta PK, Livolsi VA, Baloch Z. Does the fine-needle aspiration diagnosis of ''Hurthle-cell neoplasm/follicular neoplasm with oncocytic features'' denote increased risk of malignancy? Diagn Cytopathol. 2004;31:307-312.
24. Pu RT, Yang J, Wasserman PG, Bhuiya T, Griffith KA, Michael CW. Does Hurthle cell lesion/neoplasm predict malignancy more than follicular lesion/neoplasm on thyroid fine-needle aspiration? Diagn Cytopathol. 2006;34:330-334.
25. Roh MH, Jo VY, Stelow EB, et al. The predictive value of the fine-needle aspiration diagnosis ''suspicious for a follicular neoplasm, hurthle cell type'' in patients with hashimoto thyroiditis. Am J Clin Pathol. 2011;135:139-145.
26. Faquin WC, Cibas ES, Renshaw AA. ''Atypical'' cells in fine-needle aspiration biopsy specimens of benign thyroid cysts. Cancer (Cancer Cytopathol). 2005;105:71-79.
27. Granter SR, Cibas ES. Cytologic findings in thyroid nodules after 131I treatment of hyperthyroidism. Am J Clin Pathol. 1997;107:20-25.
28. Smejkal V, Smejkalova E, Rosa M, Zeman V, Smetana K. Cytologic changes simulating malignancy in thyrotoxic goiters treated with carbimazole. Acta Cytol. 1985;29:173-178.
29. Renshaw AA. Subclassification of atypical cells of undetermined significance in direct smears of fine-needle aspirations of the thyroid: distinct patterns and associated risk of malignancy [published online ahead of print March 25, 2011]. Cancer (Cancer Cytopathol). doi: 10.1002/cncy. 20154.
30. Muddegowda PH, Lingegowda J, Natesan R, Kurpad R. Divide and rule: cytodiagnosis of thyroid lesions using pattern analysis: a study of 233 cases [published online ahead of print November 9, 2010]. Diagn Cytopathol.
31. Shi Y, Ding X, Klein M, et al. Thyroid fine-needle aspiration with atypia of undetermined significance: a necessary or optional category? Cancer (Cancer Cytopathol). 2009; 117:298-304.
32. Jing X, Roh MH, Knoepp SM, Zhao L, Michael CW. Minimizing the diagnosis of ''follicular lesion of undetermined significance'' and identifying predictive features for neoplasia [published online ahead of print October 14, 2010]. Diagn Cytopathol.
33. Mahajan A, Kasper K, Lin X, et al. Thyroid FNA atypia of undetermined significance (AUS): variability in pathologist reporting and clinical follow-up. Mod Pathol. 2011;24(1 suppl):98.A.
34. Jing X, Knoepp SM, Roh MH, et al. Consensual review minimizes the diagnosis of ''follicular lesion of undetermined significance'' and improves reproducibility and cyto-histologic concordance. Mod Pathol. 2011;24(1 suppl):94.A.
35. VanderLaan PA, Krane JK, Cibas ES. Atypia of undetermined significance in thyroid fine-needle aspiration: characterizing cytopathologist practice patterns. Mod Pathol. 2011;24(1 suppl):108.A.
36. VanderLaan PA, Marqusee E, Krane JF. Utility of diagnostic qualifiers for thyroid fine-needle aspirations with atypia of undetermined significance. Am J Clin Pathol. In press.
37. Marchevsky AM, Walts AE, Bose S, et al. Evidence-based evaluation of the risks of malignancy predicted by thyroid fine-needle aspiration biopsies. Diagn Cytopathol. 2010;38:252-259.
38. Wu S, Demay RM, Papas P, Yan B, Reeves W. Follicular lesions of the thyroid: a retrospective study of 1,348 fine needle aspiration biopsies [published online ahead of print October 17, 2010]. Diagn Cytopathol.
39. Elsheikh TM, Asa SL, Chan JK, et al. Interobserver and intraobserver variation among experts in the diagnosis of thyroid follicular lesions with borderline nuclear features of papillary carcinoma. Am J Clin Pathol. 2008;130:736-744.
40. Yassa L, Cibas ES, Benson CB, et al. Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation. Cancer (Cancer Cytopathol). 2007;111:508-516.
41. Baloch Z, LiVolsi VA, Jain P, et al. Role of repeat fine-needle aspiration biopsy (FNAB) in the management of thyroid nodules. Diagn Cytopathol. 2003;29:203-206.
42. Faquin WC. Diagnosis and reporting of follicular-patterned thyroid lesions by fine needle aspiration. Head Neck Pathol. 2009;3:82-85.
43. Renshaw AA. Does a repeated benign aspirate change the risk of malignancy after an initial atypical thyroid fine-needle aspiration? Am J Clin Pathol. 2010;134:788-792.
44. Weber D, Brainard J, Chen L. Atypical epithelial cells, cannot exclude papillary carcinoma, in fine needle aspiration of the thyroid. Acta Cytol. 2008;52:320-324.
45. Solomon D, Nayar R. The Bethesda System for Reporting Cervical Cytology. 2nd ed. New York: Springer-Verlag; 2004.
46. Somma J, Schlecht NF, Fink D, Khader SN, Smith RV, Cajigas A. Thyroid fine needle aspiration cytology: follicular lesions and the gray zone. Acta Cytol. 2010;54:123-131.
47. Yang J, Schnadig V, Logrono R, Wasserman PG. Fine-needle aspiration of thyroid nodules: a study of 4703 patients with histologic and clinical correlations. Cancer (Cancer Cytopathol). 2007;111:306-315.
48. Bartolazzi A, Orlandi F, Saggiorato E, et al. Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study. Lancet Oncol. 2008;9:543-549.
49. Mills LJ, Poller DN, Yiangou C. Galectin-3 is not useful in thyroid FNA. Cytopathology. 2005;16:132-138.
50. Kato MA, Fahey TJ 3rd. Molecular markers in thyroid cancer diagnostics. Surg Clin North Am. 2009;89:1139-1155.
51. Cantara S, Capezzone M, Marchisotta S, et al. Impact of proto-oncogene mutation detection in cytological specimens from thyroid nodules improves the diagnostic accuracy of cytology. J Clin Endocrinol Metab. 2010; 95:1365-1369.
52. Mathur A, Weng J, Moses W, et al. A prospective study evaluating the accuracy of using combined clinical factors and candidate diagnostic markers to refine the accuracy of thyroid fine needle aspiration biopsy. Surgery. 2010;148: 1170-1176; discussion 1176-1177.
53. Melillo RM, Santoro M, Vecchio G. Differential diagnosis of thyroid nodules using fine-needle aspiration cytology and oncogene mutation screening: are we ready? F1000 Med Rep. 2010;2:62.
54. Nikiforov YE, Steward DL, Robinson-Smith TM, et al. Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules. J Clin Endocrinol Metab. 2009;94:2092-2098.
55. Nikiforova MN, Nikiforov YE. Molecular diagnostics and predictors in thyroid cancer. Thyroid. 2009;19:1351-1361.
56. Rivera M, Ricarte-Filho J, Knauf J, et al. Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. Mod Pathol. 2010;23:1191-1200.
57. Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE. Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations. Am J Clin Pathol. 2003;120:71-77.
58. Haugen BR, Baloch ZW, Chudova D, et al. Development of a novel molecular classifier to accurately identify benign thyroid nodules in patients with indeterminate FNA cytology. Presented at the 14th International Thyroid Congress; September 11-16, 2010; Paris, France.