-
2
-
-
0030031888
-
A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group
-
Barst R.J. Rubin L.J. Long W.A. McGoon M.D. Rich S. Badesch D.B. (1996) A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N Engl J Med 334: 296–302.
-
(1996)
N Engl J Med
, vol.334
, pp. 296-302
-
-
Barst, R.J.1
Rubin, L.J.2
Long, W.A.3
McGoon, M.D.4
Rich, S.5
Badesch, D.B.6
-
3
-
-
79955141941
-
Safety and efficacy of bosentan in combination with sildenafil in PAH patients who experience inadequate clinical response to monotherapy: The COMPASS-3 Study
-
Benza R.L. Gupta H. Soto F.J. Park M.H. Torres F. Frey N. Murali S. (2010) Safety and efficacy of bosentan in combination with sildenafil in PAH patients who experience inadequate clinical response to monotherapy: The COMPASS-3 Study. Chest 138: 840 A.
-
(2010)
Chest
, vol.138
, pp. 840 A
-
-
Benza, R.L.1
Gupta, H.2
Soto, F.J.3
Park, M.H.4
Torres, F.5
Frey, N.6
Murali, S.7
-
4
-
-
0025100874
-
Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide
-
Boulanger C. Luscher T.F. (1990) Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J Clin Invest 85: 587–590.
-
(1990)
J Clin Invest
, vol.85
, pp. 587-590
-
-
Boulanger, C.1
Luscher, T.F.2
-
5
-
-
33750057013
-
Renal hyporesponsiveness to brain natriuretic peptide: both generation and renal activity of cGMP are decreased in patients with pulmonary hypertension
-
Charloux A. Chaouat A. Piquard F. Brandenberger G. Weitzenblum E. Geny B. (2006) Renal hyporesponsiveness to brain natriuretic peptide: both generation and renal activity of cGMP are decreased in patients with pulmonary hypertension. Peptides 27: 2993–2999.
-
(2006)
Peptides
, vol.27
, pp. 2993-2999
-
-
Charloux, A.1
Chaouat, A.2
Piquard, F.3
Brandenberger, G.4
Weitzenblum, E.5
Geny, B.6
-
7
-
-
0027138083
-
Cellular mechanism of natriuretic peptides-induced inhibition of endothelin-1 biosynthesis in rat endothelial cells
-
Emori T. Hirata Y. Imai T. Eguchi S. Kanno K. Marumo F. (1993) Cellular mechanism of natriuretic peptides-induced inhibition of endothelin-1 biosynthesis in rat endothelial cells. Endocrinology 133: 2474–2480.
-
(1993)
Endocrinology
, vol.133
, pp. 2474-2480
-
-
Emori, T.1
Hirata, Y.2
Imai, T.3
Eguchi, S.4
Kanno, K.5
Marumo, F.6
-
10
-
-
46449124591
-
Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2
-
Galie N. Olschewski H. Oudiz R.J. Torres F. Frost A. Ghofrani H.A. (2008) Ambrisentan for the treatment of pulmonary arterial hypertension: results of the ambrisentan in pulmonary arterial hypertension, randomized, double-blind, placebo-controlled, multicenter, efficacy (ARIES) study 1 and 2. Circulation 117: 3010–3019.
-
(2008)
Circulation
, vol.117
, pp. 3010-3019
-
-
Galie, N.1
Olschewski, H.2
Oudiz, R.J.3
Torres, F.4
Frost, A.5
Ghofrani, H.A.6
-
13
-
-
0029055964
-
Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
-
Giaid A. Saleh D. (1995) Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 333: 214–221.
-
(1995)
N Engl J Med
, vol.333
, pp. 214-221
-
-
Giaid, A.1
Saleh, D.2
-
17
-
-
33847368988
-
Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension
-
Hoeper M.M. Leuchte H. Halank M. Wilkens H. Meyer F.J. Seyfarth H.J. (2006) Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur Respir J 28: 691–694.
-
(2006)
Eur Respir J
, vol.28
, pp. 691-694
-
-
Hoeper, M.M.1
Leuchte, H.2
Halank, M.3
Wilkens, H.4
Meyer, F.J.5
Seyfarth, H.J.6
-
19
-
-
15744382057
-
Addition of oral sildenafil to beraprost is a safe and effective therapeutic option for patients with pulmonary hypertension
-
Ikeda D. Tsujino I. Ohira H. Itoh N. Kamigaki M. Ishimaru S. (2005) Addition of oral sildenafil to beraprost is a safe and effective therapeutic option for patients with pulmonary hypertension. J Cardiovasc Pharmacol 45: 286–289.
-
(2005)
J Cardiovasc Pharmacol
, vol.45
, pp. 286-289
-
-
Ikeda, D.1
Tsujino, I.2
Ohira, H.3
Itoh, N.4
Kamigaki, M.5
Ishimaru, S.6
-
21
-
-
0030714983
-
Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension
-
Kharitonov S.A. Cailes J.B. Black C.M. du Bois R.M. Barnes P.J. (1997) Decreased nitric oxide in the exhaled air of patients with systemic sclerosis with pulmonary hypertension. Thorax 52: 1051–1055.
-
(1997)
Thorax
, vol.52
, pp. 1051-1055
-
-
Kharitonov, S.A.1
Cailes, J.B.2
Black, C.M.3
du Bois, R.M.4
Barnes, P.J.5
-
22
-
-
77952301237
-
Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial
-
McLaughlin V.V. Benza R.L. Rubin L.J. Channick R.N. Voswinckel R. Tapson V.F. (2010) Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. J Am Coll Cardiol 55: 1915–1922.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 1915-1922
-
-
McLaughlin, V.V.1
Benza, R.L.2
Rubin, L.J.3
Channick, R.N.4
Voswinckel, R.5
Tapson, V.F.6
-
24
-
-
0017094798
-
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
-
Moncada S. Gryglewski R. Bunting S. Vane J.R. (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263: 663–665.
-
(1976)
Nature
, vol.263
, pp. 663-665
-
-
Moncada, S.1
Gryglewski, R.2
Bunting, S.3
Vane, J.R.4
-
25
-
-
0034702908
-
Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension
-
Nagaya N. Nishikimi T. Uematsu M. Satoh T. Kyotani S. Sakamaki F. (2000) Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension. Circulation 102: 865–870.
-
(2000)
Circulation
, vol.102
, pp. 865-870
-
-
Nagaya, N.1
Nishikimi, T.2
Uematsu, M.3
Satoh, T.4
Kyotani, S.5
Sakamaki, F.6
-
26
-
-
34547611337
-
Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility
-
Nagendran J. Archer S.L. Soliman D. Gurtu V. Moudgil R. Haromy A. (2007) Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation 116: 238–248.
-
(2007)
Circulation
, vol.116
, pp. 238-248
-
-
Nagendran, J.1
Archer, S.L.2
Soliman, D.3
Gurtu, V.4
Moudgil, R.5
Haromy, A.6
-
27
-
-
0035171979
-
Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension
-
Rubens C. Ewert R. Halank M. Wensel R. Orzechowski H.D. Schultheiss H.P. (2001) Big endothelin-1 and endothelin-1 plasma levels are correlated with the severity of primary pulmonary hypertension. Chest 120: 1562–1569.
-
(2001)
Chest
, vol.120
, pp. 1562-1569
-
-
Rubens, C.1
Ewert, R.2
Halank, M.3
Wensel, R.4
Orzechowski, H.D.5
Schultheiss, H.P.6
-
29
-
-
23744496842
-
Bosentan improves exercise tolerance and Tei index in patients with pulmonary hypertension and prostanoid therapy
-
Seyfarth H.J. Pankau H. Hammerschmidt S. Schauer J. Wirtz H. Winkler J. (2005) Bosentan improves exercise tolerance and Tei index in patients with pulmonary hypertension and prostanoid therapy. Chest 128: 709–713.
-
(2005)
Chest
, vol.128
, pp. 709-713
-
-
Seyfarth, H.J.1
Pankau, H.2
Hammerschmidt, S.3
Schauer, J.4
Wirtz, H.5
Winkler, J.6
-
31
-
-
54549125950
-
Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial
-
Simonneau G. Rubin L.J. Galie N. Barst R.J. Fleming T.R. Frost A.E. (2008) Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial. Ann Intern Med 149: 521–530.
-
(2008)
Ann Intern Med
, vol.149
, pp. 521-530
-
-
Simonneau, G.1
Rubin, L.J.2
Galie, N.3
Barst, R.J.4
Fleming, T.R.5
Frost, A.E.6
-
32
-
-
0026034713
-
Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?
-
Stewart D.J. Levy R.D. Cernacek P. Langleben D. (1991) Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?. Ann Intern Med 114: 464–469.
-
(1991)
Ann Intern Med
, vol.114
, pp. 464-469
-
-
Stewart, D.J.1
Levy, R.D.2
Cernacek, P.3
Langleben, D.4
-
33
-
-
0033032949
-
Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension
-
Tuder R.M. Cool C.D. Geraci M.W. Wang J. Abman S.H. Wright L. (1999) Prostacyclin synthase expression is decreased in lungs from patients with severe pulmonary hypertension. Am J Respir Crit Care Med 159(6): 1925–1932.
-
(1999)
Am J Respir Crit Care Med
, vol.159
, Issue.6
, pp. 1925-1932
-
-
Tuder, R.M.1
Cool, C.D.2
Geraci, M.W.3
Wang, J.4
Abman, S.H.5
Wright, L.6
-
34
-
-
9444220218
-
Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension
-
Xu W. Kaneko F.T. Zheng S. Comhair S.A. Janocha A.J. Goggans T. (2004) Increased arginase II and decreased NO synthesis in endothelial cells of patients with pulmonary arterial hypertension. FASEB J 18: 1746–1748.
-
(2004)
FASEB J
, vol.18
, pp. 1746-1748
-
-
Xu, W.1
Kaneko, F.T.2
Zheng, S.3
Comhair, S.A.4
Janocha, A.J.5
Goggans, T.6
|