Granulocyte colony-stimulating factor affects the distribution and clonality of TRGV and TRDV repertoire of T cells and graft-versus-host disease

Journal of Translational Medicine

Volumn 9, Issue 1, 2011, Pages

  Xuan, Li ^a   Wu, Xiuli ^a   Zhang, Yu ^a   Fan, Zhiping ^a   Ling, Yiwen ^a   Huang, Fen ^a   Zhang, Fuhua ^a   Zhai, Xiao ^a   Liu, Qifa ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; LYMPHOCYTE ANTIGEN RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CLONAL VARIATION; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; FEMALE; GAMMA DELTA T LYMPHOCYTE; GENE EXPRESSION PROFILING; GENE FREQUENCY; GENE FUNCTION; GENE PRODUCT; GENETIC ANALYSIS; GENETIC ASSOCIATION; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; INCIDENCE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN METABOLISM; T LYMPHOCYTE; TRDV GENE; TRDV1 GENE; TRDV2 GENE; TRDV3 GENE; TRDV4 GENE; TRDV5 GENE; TRDV6 GENE; TRDV7 GENE; TRDV8 GENE; TRGV GENE; TRGVI GENE; TRGVII GENE; TRGVIII GENE; ALLOTRANSPLANTATION; CELL CLONE; DONOR; DRUG EFFECT; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; STEM CELL MOBILIZATION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; CLONE CELLS; FEMALE; GRAFT VS HOST DISEASE; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL MOBILIZATION; HUMANS; MALE; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; TISSUE DONORS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 83455169176     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-215     Document Type: Article

References (46)

1. Pan L, Bressler S, Cooke KR, Krenger W, Karandikar M, Ferrara JL. Long-term engraftment, graft-vs.-host disease, and immunologic reconstitution after experimental transplantation of allogeneic peripheral blood cells from G-CSF-treated donors. Biol Blood Marrow Transplant 1996, 2:126-133.
2. Anderlini P. Effects and safety of granulocyte colony-stimulating factor in healthy volunteers. Curr Opin Hematol 2009, 16:35-40. 10.1097/MOH.0b013e328319913c, 19057203.
3. Korbling M, Anderlini P. Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter?. Blood 2001, 98:2900-2908. 10.1182/blood.V98.10.2900, 11698269.
4. Arpinati M, Green CL, Heimfeld S, Heuser JE, Anasetti C. Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cells. Blood 2000, 95:2484-2490.
5. Mielcarek M, Martin PJ, Torok-Storb B. Suppression of alloantigen-induced T-cell proliferation by CD14+ cells derived from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells. Blood 1997, 89:1629-1634.
6. Zeng D, Dejbakhsh-Jones S, Strober S. Granulocyte colony-stimulating factor reduces the capacity of blood mononuclear cells to induce graft-versus-host disease: impact on blood progenitor cell transplantation. Blood 1997, 90:453-463.
7. Mielcarek M, Graf L, Johnson G, B T-S. Production of interleukin-10 by granulocyte colony-stimulating factor-mobilized blood products: a mechanism for monocyte-mediated suppression of T-cell proliferation. Blood 1998, 92:215-222.
8. Pan L, Delmonte J, Jalonen CK, JL F. Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host disease. Blood 1995, 86:4422-4429.
9. Groh V, Porcelli S, Fabbi M, Lanier LL, Picker LJ, Anderson T, Warnke RA, Bhan AK, Strominger JL, Brenner MB. Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system. J Exp Med 1989, 169:1277-1294. 10.1084/jem.169.4.1277, 2189233, 2564416.
10. Takihara Y, Tkachuk D, Michalopoulos E, Champagne E, Reimann J, Minden M, Mak TW. Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus. Proc Natl Acad Sci USA 1988, 85:6097-6101. 10.1073/pnas.85.16.6097, 281912, 3413078.
11. Forster A, Huck S, Ghanem N, Lefranc MP, Rabbitts TH. New subgroups in the human T cell rearranging V gamma gene locus. Embo J 1987, 6:1945-1950. 553581, 2820713.
12. Lefranc MP, Forster A, Rabbitts TH. Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene gamma. Proc Natl Acad Sci USA 1986, 83:9596-9600. 10.1073/pnas.83.24.9596, 387187, 2879283.
13. Raulet DH, Garman RD, Saito H, Tonegawa S. Developmental regulation of T-cell receptor gene expression. Nature 1985, 314:103-107. 10.1038/314103a0, 2983227.
14. Rabbitts TH, Lefranc MP, Stinson MA, Sims JE, Schroder J, Steinmetz M, Spurr NL, Solomon E, Goodfellow PN. The chromosomal location of T-cell receptor genes and a T cell rearranging gene: possible correlation with specific translocations in human T cell leukaemia. Embo J 1985, 4:1461-1465. 554368, 3875483.
15. Kabelitz D, Wesch D, Pitters E, Zoller M. Potential of human gammadelta T lymphocytes for immunotherapy of cancer. Int J Cancer 2004, 112:727-732. 10.1002/ijc.20445, 15386388.
16. Li Y, Chen S, Yang L, Li B, Chan JY, Cai D. TRGV and TRDV repertoire distribution and clonality of T cells from umbilical cord blood. Transpl Immunol 2009, 20:155-162. 10.1016/j.trim.2008.10.010, 19013241.
17. Dosenko V, Goldenberg DI. [The role of gamma-delta T-lymphocyte subtypes in normal and pathologic conditions]. Fiziol Zh 2001, 47:71-84.
18. Hao J, Wu X, Xia S, Li Z, Wen T, Zhao N, Wu Z, Wang P, Zhao L, Yin Z. Current progress in gammadelta T-cell biology. Cell Mol Immunol 2010, 7:409-413. 10.1038/cmi.2010.50, 21042298.
19. Fujishima N, Hirokawa M, Fujishima M, Yamashita J, Saitoh H, Ichikawa Y, Horiuchi T, Kawabata Y, Sawada KI. Skewed T cell receptor repertoire of Vdelta1(+) gammadelta T lymphocytes after human allogeneic haematopoietic stem cell transplantation and the potential role for Epstein-Barr virus-infected B cells in clonal restriction. Clin Exp Immunol 2007, 149:70-79. 10.1111/j.1365-2249.2007.03388.x, 1942033, 17425654.
20. Godder KT, Henslee-Downey PJ, Mehta J, Park BS, Chiang KY, Abhyankar S, Lamb LS. Long term disease-free survival in acute leukemia patients recovering with increased gammadelta T cells after partially mismatched related donor bone marrow transplantation. Bone Marrow Transplant 2007, 39:751-757. 10.1038/sj.bmt.1705650, 17450185.
21. Carding SR, Egan PJ. Gammadelta T cells: functional plasticity and heterogeneity. Nat Rev Immunol 2002, 2:336-345. 10.1038/nri797, 12033739.
22. Zhang X, Chen S, Yang L, Li B, Zhu K, Li Y. The feature of TRGV and TRDV repertoire distribution and clonality in patients with immune thrombocytopenic purpura. Hematology 2009, 14:237-244. 10.1179/102453309X439755, 19635188.
23. Rutella S, Zavala F, Danese S, Kared H, Leone G. Granulocyte colony-stimulating factor: a novel mediator of T cell tolerance. J Immunol 2005, 175:7085-7091.
24. Franzke A, Piao W, Lauber J, Gatzlaff P, Konecke C, Hansen W, Schmitt-Thomsen A, Hertenstein B, Buer J, Ganser A. G-CSF as immune regulator in T cells expressing the G-CSF receptor: implications for transplantation and autoimmune diseases. Blood 2003, 102:734-739. 10.1182/blood-2002-04-1200, 12676791.
25. Rutella S, Rumi C, Sica S, Leone G. Recombinant human granulocyte colony-stimulating factor (rHuG-CSF): effects on lymphocyte phenotype and function. J Interferon Cytokine Res 1999, 19:989-994. 10.1089/107999099313181, 10505739.
26. Morikawa K, Morikawa S, Nakamura M, Miyawaki T. Characterization of granulocyte colony-stimulating factor receptor expressed on human lymphocytes. Br J Haematol 2002, 118:296-304. 10.1046/j.1365-2141.2002.03574.x, 12100165.
27. Huang Y, Cramer DE, Ray MB, Chilton PM, Que X, Ildstad ST. The role of alphabeta- and gammadelta-T cells in allogenic donor marrow on engraftment, chimerism, and graft-versus-host disease. Transplantation 2001, 72:1907-1914. 10.1097/00007890-200112270-00007, 11773887.
28. Morita CT, Mariuzza RA, Brenner MB. Antigen recognition by human gamma delta T cells: pattern recognition by the adaptive immune system. Springer Semin Immunopathol 2000, 22:191-217. 10.1007/s002810000042, 11116953.
29. Eberl M, Hintz M, Reichenberg A, Kollas AK, Wiesner J, Jomaa H. Microbial isoprenoid biosynthesis and human gammadelta T cell activation. FEBS Lett 2003, 544:4-10. 10.1016/S0014-5793(03)00483-6, 12782281.
30. Maeda Y, Reddy P, Lowler KP, Liu C, Bishop DK, Ferrara JL. Critical role of host gammadelta T cells in experimental acute graft-versus-host disease. Blood 2005, 106:749-755. 10.1182/blood-2004-10-4087, 1895173, 15797996.
31. Vodanovic-Jankovic S, Drobyski WR. Gammadelta T cells do not require fully functional cytotoxic pathways or the ability to recognize recipient alloantigens to prevent graft rejection. Biol Blood Marrow Transplant 2006, 12:1125-1134. 10.1016/j.bbmt.2006.08.033, 1679815, 17085305.
32. Tsuji S, Char D, Bucy RP, Simonsen M, Chen CH, Cooper MD. Gamma delta T cells are secondary participants in acute graft-versus-host reactions initiated by CD4+ alpha beta T cells. Eur J Immunol 1996, 26:420-427. 10.1002/eji.1830260223, 8617313.
33. Ellison CA, MacDonald GC, Rector ES, Gartner JG. Gamma delta T cells in the pathobiology of murine acute graft-versus-host disease. Evidence that gamma delta T cells mediate natural killer-like cytotoxicity in the host and that elimination of these cells from donors significantly reduces mortality. J Immunol 1995, 155:4189-4198.
34. Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Barrett TA, Bluestone JA, Vallera DA. Lethal murine graft-versus-host disease induced by donor gamma/delta expressing T cells with specificity for host nonclassical major histocompatibility complex class Ib antigens. Blood 1996, 87:827-837.
35. Shiohara T, Moriya N, Hayakawa J, Itohara S, Ishikawa H. Resistance to cutaneous graft-vs.-host disease is not induced in T cell receptor delta gene-mutant mice. J Exp Med 1996, 183:1483-1489. 10.1084/jem.183.4.1483, 2192502, 8666906.
36. Drobyski WR, Vodanovic-Jankovic S, Klein J. Adoptively transferred gamma delta T cells indirectly regulate murine graft-versus-host reactivity following donor leukocyte infusion therapy in mice. J Immunol 2000, 165:1634-1640.
37. Gorochov G, Debre P, Leblond V, Sadat-Sowti B, Sigaux F, Autran B. Oligoclonal expansion of CD8+ CD57+ T cells with restricted T-cell receptor beta chain variability after bone marrow transplantation. Blood 1994, 83:587-595.
38. Hirokawa M, Horiuchi T, Kawabata Y, Kitabayashi A, Miura AB. Reconstitution of gammadelta T cell repertoire diversity after human allogeneic hematopoietic cell transplantation and the role of peripheral expansion of mature T cell population in the graft. Bone Marrow Transplant 2000, 26:177-185. 10.1038/sj.bmt.1702478, 10918428.
39. Ferrick DA, Schrenzel MD, Mulvania T, Hsieh B, Ferlin WG, Lepper H. Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature 1995, 373:255-257. 10.1038/373255a0, 7816142.
40. Skeen MJ, Ziegler HK. Activation of gamma delta T cells for production of IFN-gamma is mediated by bacteria via macrophage-derived cytokines IL-1 and IL-12. J Immunol 1995, 154:5832-5841.
41. Kawano Y, Kim HT, Matsuoka KI, Bascug G, McDonough S, Ho VT, Cutler C, Koreth J, Alyea EP, Antin JH, Soiffer RJ, Ritz J. Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation. Blood 2011, 118:5021-5030. 10.1182/blood-2011-06-362137, 21900196.
42. Ladel CH, Blum C, Kaufmann SH. Control of natural killer cell-mediated innate resistance against the intracellular pathogen Listeria monocytogenes by gamma/delta T lymphocytes. Infect Immun 1996, 64:1744-1749. 173987, 8613386.
43. Yurchenko E, Levings MK, Piccirillo CA. CD4(+) Foxp3(+) regulatory T cells suppress gamma delta T-cell effector functions in a model of T cell-induced mucosal inflammation. Eur J Immunol 2011, doi: 10.1002/eji.201141814.
44. Nishimura H, Emoto M, Hiromatsu K, Yamamoto S, Matsuura K, Gomi H, Ikeda T, Itohara S, Yoshikai Y. The role of gamma delta T cells in priming macrophages to produce tumor necrosis factor-alpha. Eur J Immunol 1995, 25:1465-1468. 10.1002/eji.1830250551, 7539762.
45. Anderson BE, McNiff JM, Matte C, Athanasiadis I, Shlomchik WD, Shlomchik MJ. Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. Blood 2004, 104:1565-1573. 10.1182/blood-2004-01-0328, 15150080.
46. Pabst C, Schirutschke H, Ehninger G, Bornhauser M, Platzbecker U. The graft content of donor T cells expressing gamma delta TCR+ and CD4+foxp3+ predicts the risk of acute graft versus host disease after transplantation of allogeneic peripheral blood stem cells from unrelated donors. Clin Cancer Res 2007, 13:2916-2922. 10.1158/1078-0432.CCR-06-2602, 17504991.