The integrated HIV-1 provirus in patient sperm chromosome and its transfer into the early embryo by fertilization

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Wang, Dian ^a   Li, Lian Bing ^b   Hou, Zhi Wei ^b   Kang, Xiang Jin ^a   Xie, Qing Dong ^a   Yu, Xiao Jun ^a   Ma, Ming Fu ^b   Ma, Bo Lu ^c   Wang, Zheng Song ^c   Lei, Yong ^c   Huang, Tian Hua ^a  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b Chongqing Key Laboratory of Birth Defects and Reproductive Health   (China)

^c Jiangbei District Center for Disease Control and Prevention   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; POL PROTEIN; VIRUS DNA;

ADULT; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; FERTILIZATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; INTERPHASE; MALE; METAPHASE; NONHUMAN; PROVIRUS; SENSITIVITY AND SPECIFICITY; SPERM; SYRIAN HAMSTER; VERTICAL TRANSMISSION; VIRUS CELL INTERACTION; VIRUS EXPRESSION; VIRUS GENOME; VIRUS REPLICATION; VIRUS TRANSMISSION; ANIMAL; ANIMAL EMBRYO; BIOTINYLATION; CELL NUCLEUS; FERTILIZATION IN VITRO; FLUORESCENT ANTIBODY TECHNIQUE; HAMSTER; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; OOCYTE; PHYSIOLOGY; SEX CHROMOSOME; SPERMATOZOON; VIROLOGY; VIRUS DNA CELL DNA INTERACTION;

ANIMALS; BIOTINYLATION; CELL NUCLEUS; CRICETINAE; EMBRYO, MAMMALIAN; FERTILIZATION IN VITRO; FLUORESCENT ANTIBODY TECHNIQUE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV CORE PROTEIN P24; HIV INFECTIONS; HIV-1; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; OVUM; POL GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; PROVIRUSES; SEX CHROMOSOMES; SPERMATOZOA; VIRUS INTEGRATION; VIRUS REPLICATION;

EID: 83355173209     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028586     Document Type: Article

References (27)

1. Galvin S, Cohen M, (2004) The role of sexually transmitted diseases in HIV transmission. Nat Rev Microbiol 2: 33-42.
2. Münch J, Rücker E, Ständker L, Adermann K, Goffinet C, et al. (2007) Semen-derived amyloid fibrils drastically enhance HIV infection. Cell 131: 1059-1071.
3. Ceballos A, Lenicov FR, Sabatté J, Rodríguez Rodrígues C, Cabrini M, Raiden S, et al. (2009) Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells. J Exp Med 206: 2717-2733.
4. Le Tortorec A, Dejucq-Rainsford N, (2010) HIV infection of the male genital tract-consequences for sexual transmission and reproduction. Int J Androl 33: e98-108.
5. Bagasra O, Farzadegan H, Seshamma T, Oakes J, Saah A, et al. (1994) Detection of HIV-1 proviral DNA in sperm from HIV-1-infected men. AIDS 8: 1669-1674.
6. Muciaccia B, Uccini S, Filippini A, Ziparo E, Paraire F, et al. (1998) Presence and cellular distribution of HIV in the testes of seropositive subjects: an evaluation by in situ PCR hybridization. Faseb Journal 12: 151-163.
7. Muciaccia B, Corallini S, Vicini E, Padula F, Gandini L, et al. (2007) HIV-1 viral DNA is present in ejaculated abnormal spermatozoa of seropositive subjects. Hum Reprod 22: 2868-2878.
8. Piomboni P, Baccetti B, (2000) Spermatozoon as a vehicle for HIV-1 and other viruses: a review. Mol Reprod Dev 56: 238-242.
9. Nuovo G, Becker J, Simsir A, Margiotta M, Khalife G, et al. (1994) HIV-1 nucleic acids localize to the spermatogonia and their progeny. A study by polymerase chain reaction in situ hybridization. Am J Pathol 144: 1142-1148.
10. Baccetti B, Benedetto A, Burrini A, Collodel G, Ceccarini E, et al. (1994) HIV-particles in spermatozoa of patients with AIDS and their transfer into the oocyte. J Cell Biol 127: 903-914.
11. Pinney J, Dickerson J, Fu W, Sanders-Beer B, Ptak R, et al. (2009) HIV-host interactions: a map of viral perturbation of the host system. AIDS 23: 549-554.
12. Trkola A, (2004) HIV-host interactions: vital to the virus and key to its inhibition. Curr Opin Microbiol 7: 555-559.
13. Barbonetti A, Vassallo M, Pelliccione F, D'Angeli A, Santucci R, et al. (2009) Beta-chemokine receptor CCR5 in human spermatozoa and its relationship with seminal parameters. Hum Reprod 24: 2979-2987.
14. Muciaccia B, Padula F, Vicini E, Gandini L, Lenzi A, et al. (2005) Beta-chemokine receptors 5 and 3 are expressed on the head region of human spermatozoon. FASEB J 19: 2048-2050.
15. Muciaccia B, Padula F, Gandini L, Lenzi A, Stefanini M, (2005) HIV-1 chemokine co-receptor CCR5 is expressed on the surface of human spermatozoa. AIDS 19: 1424-1426.
16. Cardona-Maya W, López-Herrera A, Velilla-Hernández P, Rugeles M, Cadavid A, (2006) The role of mannose receptor on HIV-1 entry into human spermatozoa. Am J Reprod Immunol 55: 241-245.
17. Lavitrano M, Camaioni A, Fazio V, Dolci S, Farace M, et al. (1989) Sperm cells as vectors for introducing foreign DNA into eggs: genetic transformation of mice. Cell 57: 717-723.
18. Spadafora C, (1998) Sperm cells and foreign DNA: a controversial relation. Bioessays 20: 955-964.
19. Schröder A, Shinn P, Chen H, Berry C, Ecker J, et al. (2002) HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110: 521-529.
20. Rudak E, Jacobs P, Yanagimachi R, (1978) Direct analysis of the chromosome constitution of human spermatozoa. Nature 274: 911-913.
21. Kamiguchi Y, Mikamo K, (1986) An improved, efficient method for analyzing human sperm chromosomes using zona-free hamster ova. Am J Hum Genet 38: 724-740.
22. Magnano A, Giordano R, Moscufo N, Baccetti B, Spadafora C, (1998) Sperm/DNA interaction: integration of foreign DNA sequences in the mouse sperm genome. J Reprod Immunol 41: 187-196.
23. Zoraqi G, Spadafora C, (1997) Integration of foreign DNA sequences into mouse sperm genome. DNA Cell Biol 16: 291-300.
24. Giordano R, Magnano A, Zaccagnini G, Pittoggi C, Moscufo N, et al. (2000) Reverse transcriptase activity in mature spermatozoa of mouse. J Cell Biol 148: 1107-1113.
25. Wang D, Kang XJ, Li LB, Xie QD, Gao YS, et al. (2011) In vitro study on vertical transmission of the HIV-1 gag gene by human sperm. J Med Virol 83: 16-23.
26. Ali B, Huang T, Salem H, Xie Q, (2006) Expression of hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome. Asian J Androl 8: 273-279.
27. Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG, et al. (2002) Studies on the integration of hepatitis B virus DNA sequence in human sperm chromosomes. Asian Journal of Andrology 4: 209-212.