Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction

Translational Stroke Research

Volumn 2, Issue 4, 2011, Pages 643-650

  Morse, Leslie R ^a,b,c   Xu, Yan ^b,e   Solomon, Bethlehem ^b   Boyle, Lara ^b   Yoganathan, Subbiah ^b   Stashenko, Philip ^b,d   Battaglino, Ricardo A ^b,d  

^a American Journal of Physical Medicine and Rehabilitation   (United States)

^b FORSYTH INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^e KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

Chondrocyte; Osteoblast; Osteoporosis; Rehabilitation medicine; Spinal cord injury

Indexed keywords

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BONE LESION; CARTILAGE CELL; CELL ACTIVITY; CELL DISRUPTION; CELL PROLIFERATION; CONTROLLED STUDY; FUNCTIONAL DISEASE; GROWTH PLATE; HISTOLOGY; INJURY SEVERITY; MALE; METAPHYSIS; MICROENVIRONMENT; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY;

EID: 83355163231     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-011-0118-9     Document Type: Article

References (32)

1. Kocina P. Body composition of spinal cord injured adults. Sports Med. 1997; 23: 48-60.
2. Dauty M, Perrouin VB, Maugars Y, Dubois C, Mathe JF. Supralesional and sublesional bone mineral density in spinal cord-injured patients. Bone. 2000; 27: 305-9.
3. Garland DE, Stewart CA, Adkins RH, Hu SS, Rosen C, Liotta FJ, et al. Osteoporosis after spinal cord injury. J Orthop Res. 1992; 10: 371-8.
4. Garland DE, Adkins RH, Kushwaha V, Stewart C. Risk factors for osteoporosis at the knee in the spinal cord injury population. J Spinal Cord Med. 2004; 27: 202-6.
5. Demirel G, Yilmaz H, Paker N, Onel S. Osteoporosis after spinal cord injury. Spinal Cord. 1998; 36: 822-5.
6. Eser P, Schiessl H, Willnecker J. Bone loss and steady state after spinal cord injury: a cross-sectional study using pQCT. J Musculoskelet Neuronal Interact. 2004; 4: 197-8.
7. Szollar SM, Martin EM, Parthemore JG, Sartoris DJ, Deftos LJ. Demineralization in tetraplegic and paraplegic man over time. Spinal Cord. 1997; 35: 223-8.
8. Wilmet E, Ismail AA, Heilporn A, Welraeds D, Bergmann P. Longitudinal study of the bone mineral content and of soft tissue composition after spinal cord section. Paraplegia. 1995; 33: 674-7.
9. Garland DE, Saucedo T, Reiser TV. The management of tibial fractures in acute spinal cord injury patients. Clin Orthop Relat Res. 1986; 213: 237-40.
10. McMaster WC, Stauffer ES. The management of long bone fracture in the spinal cord injured patient. Clin Orthop Relat Res. 1975; 112: 44-52.
11. Nottage WM. A review of long-bone fractures in patients with spinal cord injuries. Clin Orthop Relat Res. 1981; 155: 65-70.
12. Morse LR, Giangregori L, Battaglino RA, Holland R, Craven BC, Stolzmann K, et al. VA-based survey of osteoporosis management in spinal cord injury. PMR. 2009; 1: 240-4. 3-1-0009. Ref Type: Journal (Full).
13. Morse LR, Battaglino RA, Stolzmann KL, Hallett LD, Waddimba A, Gagnon D, et al. Osteoporotic fractures and hospitalization risk in chronic spinal cord injury. Osteoporos Int. 2009; 20: 385-92.
14. Campbell J, Bonnett C. Spinal cord injury in children. Clin Orthop Relat Res. 1975; 112: 114-23.
15. Duval-Beaupere G, Lougovoy J, Trocellier L, Lacert P. Trunk and leg growth in children with paraplegia caused by spinal cord injury. Paraplegia. 1983; 21: 339-50.
16. Morse L, Teng YD, Pham L, Newton K, Yu D, Liao WL, et al. Spinal cord injury causes rapid osteoclastic resorption and growth plate abnormalities in growing rats (SCI-induced bone loss in growing rats). Osteoporos Int. 2008; 19: 645-52.
17. Roberts D, Lee W, Cuneo RC, Wittmann J, Ward G, Flatman R, et al. Longitudinal study of bone turnover after acute spinal cord injury. J Clin Endocrinol Metab. 1998; 83: 415-22.
18. Szollar SM, Martin EM, Sartoris DJ, Parthemore JG, Deftos LJ. Bone mineral density and indexes of bone metabolism in spinal cord injury. Am J Phys Med Rehabil. 1998; 77: 28-35.
19. Uebelhart D, Hartmann D, Vuagnat H, Castanier M, Hachen HJ, Chantraine A. Early modifications of biochemical markers of bone metabolism in spinal cord injury patients. A preliminary study. Scand J Rehabil Med. 1994; 26: 197-202.
20. Basso N, Heersche JN. Effects of hind limb unloading and reloading on nitric oxide synthase expression and apoptosis of osteocytes and chondrocytes. Bone. 2006; 39: 807-14.
21. Vashishth D, Verborgt O, Divine G, Schaffler MB, Fyhrie DP. Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age. Bone. 2000; 26: 375-80.
22. Verborgt O, Gibson GJ, Schaffler MB. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res. 2000; 15: 60-7.
23. Kogianni G, Mann V, Noble BS. Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction. J Bone Miner Res. 2008; 23: 915-27.
24. Hecht JT, Makitie O, Hayes E, Haynes R, Susic M, Montufar-Solis D, et al. Chondrocyte cell death and intracellular distribution of COMP and type IX collagen in the pseudoachondroplasia growth plate. J Orthop Res. 2004; 22: 759-67.
25. Montufar-Solis D, Duke PJ, Durnova G. Spaceflight and age affect tibial epiphyseal growth plate histomorphometry. J Appl Physiol. 1992; 73: 19S-25.
26. Moriyama H, Yoshimura O, Kawamata S, Takayanagi K, Kurose T, Kubota A, et al. Alteration in articular cartilage of rat knee joints after spinal cord injury. Osteoarthr Cartil. 2008; 16: 392-8.
27. Moriyama H, Nishihara K, Hosoda M, Saka Y, Kanemura N, Takayanagi K, et al. Contrasting alteration patterns of different cartilage plates in knee articular cartilage after spinal cord injury in rats. Spinal Cord. 2009; 47: 218-24.
28. van der Eerden BC, Karperien M, Gevers EF, Lowik CW, Wit JM. Expression of Indian hedgehog, parathyroid hormone-related protein, and their receptors in the postnatal growth plate of the rat: evidence for a locally acting growth restraining feedback loop after birth. J Bone Miner Res. 2000; 15: 1045-55.
29. Gullickson Jr G, Olson M, Kottke FJ. The effect of paralysis of one lower-extremity on bone growth. Arch Phys Med Rehabil. 1950; 31: 392-400.
30. Ring PA. Shortening and paralysis in poliomyelitis. Lancet. 1957; 273: 980-3.
31. Jepsen KJ, Price C, Silkman LJ, Nicholls FH, Nasser P, Hu B, et al. Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing. J Bone Miner Res. 2008; 23: 1204-16.
32. Aro H, Eerola E, Aho AJ. Fracture healing in paraplegic rats. Acta Orthop Scand. 1985; 56: 228-32.