Pharmacokinetics, pharmacodynamics, tolerability and safety of single doses of bivalirudin in healthy Chinese subjects

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 12, 2011, Pages 1841-1848

  Zhang, Dongmei ^a   Wang, Zining ^a   Zhao, Xia ^a   Lu, Wei ^b   Gu, Jingkai ^c   Cui, Yimin ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

^c JILIN UNIVERSITY   (China)

Author keywords

Anticoagulant; Bivalirudin; Healthy Chinese subject; Pharmacodynamics; Pharmacokinetics

Indexed keywords

HIRULOG; PLACEBO; UREA;

ADULT; ANTICOAGULATION; AREA UNDER THE CURVE; ARTICLE; BLEEDING; BLOOD CLOTTING TIME; BOLUS INJECTION; CAUCASIAN; CHINESE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE ESCALATION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG INFUSION; DRUG SAFETY; DRUG TOLERABILITY; ELECTROCARDIOGRAM; FEMALE; HUMAN; HUMAN CELL; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MORNING DOSAGE; NEUTROPHIL COUNT; PARALLEL DESIGN; PARTIAL THROMBOPLASTIN TIME; PHARMACODYNAMICS; PHARMACOKINETICS; PROTHROMBIN TIME; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE BLIND PROCEDURE; SINGLE DRUG DOSE; UREA BLOOD LEVEL; VITAL SIGN;

EID: 83255164196     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.1841     Document Type: Article

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