The pH sensitivity of -NH exchange in LnDOTA-tetraamide complexes varies with amide substituent

Contrast Media and Molecular Imaging

Volumn 6, Issue 6, 2011, Pages 459-464

  Opina, Ana Christina L ^a   Wu, Yunkou ^a   Zhao, Piyu ^a   Kiefer, Garry ^a,c   Sherry, A Dean ^a,b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Macrocyclics   (United States)

Author keywords

Amide proton exchange; Chemical exchange saturation transfer (CEST) agents; Contrast agents; MRI; Paramagnetic agents; pH responsive agents; Ratiometric analysis

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; AMIDE; LANTHANUM; NITROGEN; THULIUM; YTTERBIUM;

ARTICLE; CATALYSIS; CHEMICAL EXCHANGE SATURATION TRANSFER; CHEMICAL STRUCTURE; COMPLEX FORMATION; MOLECULAR IMAGING; MOLECULAR STABILITY; PH; PRIORITY JOURNAL; PROTON TRANSPORT;

AMIDES; BISMUTH; CONTRAST MEDIA; DRUG COMBINATIONS; GLYCINE; HETEROCYCLIC COMPOUNDS, 1-RING; HYDROGEN-ION CONCENTRATION; INDENES; LANTHANOID SERIES ELEMENTS; MAGNETIC RESONANCE IMAGING; PIPERAZINES; PROPANOLAMINES; PROTONS; WATER;

EID: 83155185495     PISSN: 15554309     EISSN: 15554317     Source Type: Journal    
DOI: 10.1002/cmmi.445     Document Type: Article

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