Adhesion molecules and high-sensitivity C-reactive protein levels in patients with sickle cell beta-thalassaemia

European Journal of Clinical Investigation

Volumn 42, Issue 1, 2012, Pages 27-33

  Kanavaki, Ino ^a   Makrythanasis, Periklis ^a,c   Lazaropoulou, Christina ^a   Kattamis, Antonis ^b   Tzanetea, Revekka ^b   Kalotychou, Vassiliki ^b   Rombos, Ioannis ^b   Papassotiriou, Ioannis ^a  

^a AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Adhesion molecules; Endothelial dysfunction; Sickle cell disease

Indexed keywords

C REACTIVE PROTEIN; CELL ADHESION MOLECULE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HYDROXYUREA; INTERCELLULAR ADHESION MOLECULE 1; PADGEM PROTEIN; THROMBOMODULIN; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; BLOOD TRANSFUSION; CAUCASIAN; CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HOMOZYGOTE; HUMAN; IMMUNOASSAY; INFLAMMATION; MALE; PHLEBOTOMY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SICKLE CELL BETA THALASSEMIA; SPLENECTOMY;

ADOLESCENT; ADULT; ANEMIA, SICKLE CELL; BETA-THALASSEMIA; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; CELL ADHESION MOLECULES; CHILD; CHILD, PRESCHOOL; ENDOTHELIUM; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GREECE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 83155180630     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2011.02551.x     Document Type: Article

References (20)

1. Stuart MJ, Nagel RL. Sickle-cell disease. Lancet 2004;364:1343-60.
2. Conran N, Costa FF. Hemoglobin disorders and endothelial cell interactions. Clin Biochem 2009;42:1824-38.
3. Ashley-Koch A, Yang Q, Olney RS. Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review. Am J Epidemiol 2000;151:839-45.
4. Hoover R, Rubin R, Wise G, Warren R. Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures. Blood 1979;54:872-6.
5. Hebbel R., Boogaerts M., Eaton J., Steinberg M.H. Erythrocyte adherence to endothelium in Sickle-Cell Anemia-A possible determinant of disease severity. N Engl J Med 1980;302:992-995.
6. Frenette PS, Atweh GF. Sickle cell disease: old discoveries, new concepts, and future promise. J Clin Invest 2007;117:850-8.
7. Mack AK, Kato GJ. Sickle cell disease and nitric oxide: a paradigm shift? Int J Biochem Cell Biol 2006;38:1237-43.
8. Makis AC, Hatzimichael EC, Bourantas KL. The role of cytokines in sickle cell disease. Ann Hematol 2000;79:407-13.
9. Conran N, Fattori A, Saad ST, Costa FF. Increased levels of soluble ICAM-1 in the plasma of sickle cell patients are reversed by hydroxyurea. Am J Hematol 2004;76:343-7.
10. Pathare A, Kindi SA, Daar S, Dennison D. Cytokines in sickle cell disease. Hematology 2003;8:329-37.
11. Francis RB Jr. Platelets, coagulation, and fibrinolysis in sickle cell disease: their possible role in vascular occlusion. Blood Coagul Fibrinolysis 1991;2:341-53.
12. Hagar W, Vichinsky E. Advances in clinical research in sickle cell disease. Br J Haematol 2008;141:346-56.
13. Akohoue SA, Shankar S, Milne GL, Morrow J, Chen KY, Ajayi WU et al. Energy expenditure, inflammation, and oxidative stress in steady-state adolescents with sickle cell anemia. Pediatr Res 2007;61:233-8.
14. Kato GJ, Martyr S, Blackwelder WC, Nichols JS, Coles WA, Hunter LA et al. Levels of soluble endothelium-derived adhesion molecules in patients with sickle cell disease are associated with pulmonary hypertension, organ dysfunction, and mortality. Br J Haematol 2005;130:943-53.
15. Blum A, Yeganeh S, Peleg A, Vigder F, Kryuger K, Khatib A et al. Endothelial function in patients with sickle cell anemia during and after sickle cell crises. J Thromb Thrombolysis 2005;19:83-6.
16. Makis AC, Hatzimichael EC, Stebbing J, Bourantas KL. C-reactive protein and vascular cell adhesion molecule-1 as markers of severity in sickle cell disease. Arch Intern Med 2006;166:366-8.
17. Krishnan S, Setty Y, Betal SG, Vijender V, Rao K et al. Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises. Br J Haematol 2010;148:797-804.
18. Rombos Y, Tzanetea R, Kalotychou V, Konstantopoulos K, Simitzis S, Tassiopoulos T et al. Amelioration of painful crises in sickle cell disease by therapeutic phlebotomys. Blood Cells Mol Dis 2002;28:283-7.
19. Bouchair N, Manigne P, Kanfer A, Raphalen P, de Montalembert M, Hagege I et al. Prevention of sickle cell crises with multiple phlebotomies. Arch Pediatr 2000;7:249-55.
20. Markham MJ, Lottenberg R, Zumberg M. Role of phlebotomy in the management of hemoglobin SC disease: case report and review of the literature. Am J Hematol 2003;73:121-5.